Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"epithelial organoids"”.
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
… core group of stress-related genes in intestinal epithelial organoids in response to endoplasmic reticulum (ER) stress and nutrient starvation, including transcription factors, chemokines, and genes involved in inflammation. The landscape of alternative splicing (AS) was also strongly affected by …
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The Role of Insulin-like Growth Factor-I and IGF-binding Proteins in Mammary Gland Development
… 545% and 28%, respectively, in primary mammary epithelial organoids in collagen gel culture. Addition of IGFBP-3 strongly inhibited this growth response. High feeding level tended to increase IGFBP-3 levels in mammary tissue and reduced by 30% the growth response to mammary tissue extracts. …
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Multiomic Investigation of the Human Gut Toward Insight into Childhood Inflammatory Bowel Disease Pathogenesis
… require identification of both the immune and epithelial contributions to disease in susceptible individuals as well as detangling the contributions of different pathways and genes, all in a cell type specific context. This thesis summarizes my research into the gene regulatory architecture of …
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Dissecting the spatio-temporal development of the human reproductive tract
… of early reproductive development, including epithelial transcriptional signatures associated with Müllerian duct emergence and elongation, and novel male-biased genes expressed in the Müllerian mesenchyme likely involved in duct regression. I also identified potential regulators of sexual …
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Nutritional status dictates the rate and mode of intestinal epithelial stem cell proliferation through an AMPK dependent mechanism
… in tissue size by increasing the number of epithelial cells, villi height and crypt depth. Because increases in tissue size are under the control of stem cells located within the tissue, I investigated if and how the amount of food may drive increases in the rate and mode (asymmetric vs. …
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The Use of 2D and 3D Models to Study Competition in the Context of Barrett’s Oesophagus and Oesophageal Adenocarcinoma
… **Methods**: BO and OAC patient derived epithelial organoids were utilised to study competition in 3D. Co-cultures were generated from fluorescently tagged BO and OAC organoids and imaged for analysis. Fusion events between BO and OAC organoids were captured by wide-field microscopy and …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… detected using endometrial derived stromal and epithelial cells in vitro? METHODS: Endometrial samples from a Female Reproductive Tissue Tract Resource (University of Edinburgh: REC Approvals: 20/ES/0119; 19/SS/0102) were categorised according to patient’s clinical history, menstrual cycle stage …
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Elucidation of mammary gland development: combination of novel techniques to study proliferation and stem cells
… the use of culture methods in examining mammary epithelial cell dynamics. By combination of these techniques, clonally marked regions can be investigated throughout the development of the mammary gland, from the formation of the embryonic mammary iii rudiment, to expansion of the ductal tree in …