Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"epithelial morphogenesis"”.
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Bioartificial matrices to modulate epithelial morphogenesis
Acute injury of major epithelial organ systems (kidney, liver, lung, etc.) is collectively a principal cause of death worldwide. Regenerative medicine promises to meet these human health challenges by harnessing intrinsic cellular processes to repair or replace damaged tissues. Epithelial …
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
Epithelial cells line all surfaces of the body exposed to external environments where they perform critical roles for maintaining homeostasis. In addition, epithelial cells are implicated in several disease processes and are the most common cell type implicated in cancer. Therefore, understanding …
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Genetic Analysis Of Rhoa Signaling During Epithelial Morphogenesis In Drosophila
Epithelial morphogenesis is contingent upon cell shape changes. Cell shape changes are the driving force for the metamorphosis of the adult Drosophila leg from the leg imaginal disc precursor. Genetic analysis has identified several Drosophila genes involved in regulating cell shape changes during …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… of the GTPase Rho1 by DRhoGEF2 during morphogenesis of the Drosophila embryonic epidermis. DRhoGEF2 is the Drosophila ortholog of the human RhoGEFs, LARG (Leukemia-associated RhoGEF), PDZ-RhoGEF and p115 RhoGEFs. In addition to a catalytic module, DRhoGEF2 encompasses an N-terminal …
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The localisation and role of Sidekick at apical vertices in Drosophila epithelial morphogenesis
During animal development, epithelial tissues undergo morphogenesis in order to build tissues, organs and body structure. A key driving force in epithelial morphogenesis is cell rearrangement, which results from the remodelling of cell-cell contacts. In epithelia, cell-cell contacts are connected …
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Notopleural Mutations Enhance Defects In Imaginal Disc Epithelial Morphogenesis And Macrochete Elongation Associated With Mutations in the Stubble-Stubbloid Locus
… proper formation of sensory bristles, and the morphogenesis of leg and wing epithelia. Genetic and cell biological analysis indicate a role for Stubble in actin cytoskeletal dynamics and cell shape changes in developing epithelia and bristles. Previously reported genetic interactions between …
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Morphogenesis of follicular epithelium in Drosophila melanogaster: function of von Hippel-Lindau tumour suppressor gene
… been involved in several projects regarding the morphogenesis of the follicular epithelium, such as the analysis of the pathways that correlate follicular epithelium patterning and eggshell genes expression. Moreover, I used the follicular epithelium as a model system to analyze the function of …
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Nherf1 – New Modifier of Colorectal Cancer Progression
… In Caco-2 cell models, NHERF1 depletion induced epithelial-mesenchymal-transition in 2D cell monolayers and disruption of apical-basal polarity in 3D cyst system. The mesenchymal phenotype of NHERF1-depleted cells was fully restored by re-expression of NHERF1 at the apical membrane. Cytoplasmic …
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Elucidating the Role of Cellular Architecture in the Developing Pancreas
… pancreas mediates cell fate specification and epithelial organization. In order to address some of the remaining gaps in the field, we proceeded to characterize the Pdx1-/- embryo, a mutant in which pancreatic cell fate and architecture had been reported to fail early in its development, to …
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Basal constriction : shaping the vertebrate brain
… and changes in cell shape and size drive epithelial bending and folding during morphogenesis. These shape changes include constriction and expansion of the cell surfaces, elongation or shortening of the apical-basal length, or cell spreading. In this thesis, I present the first description …
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Modeling mammary epithelial cell polarization and the role of podocalyxin in breast tumor progression
… gland consists of an organized network of epithelial ducts and lobules. This histoarchitecture can be recapitulated in vitro by culturing mammary epithelial cells as 3D spheroids embedded in a reconstituted basement membrane. I first used this assay to characterize the role of cell-cell and …
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Multiple roles of epithelial signaling during craniofacial and foregut morphogenesis
… and signaling within and from this epithelial tissue is necessary for the development of the mandible, the esophagus, and the trachea. Many birth defects occur in these structures that greatly disrupt the ability of affected infants to breathe and eat. This dissertation investigates …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… remain, particularly in the context of uterine epithelial morphogenesis and PCP signaling during implantation. Research and animal models to study PCP signaling, specifically the unstudied role of PRICKLE proteins, are crucial for elucidating the molecular mechanisms of uterine receptivity, …
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Function of Spectrin cytoskeleton in regulating epithelial architecture.
Epithelial cells surround every organ of the human body and about 85% of cancers arise from epithelial cells. These cells are highly polarized having distinct apical and basolateral sides; they are tightly connected to each other through cell-cell junctions. Epithelial morphogenesis is important …