Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 361 for “"epithelial cell"”.
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FUNCTIONAL STUDY OF MAMMARY EPITHELIAL CELL ARCHITECTURE
Cell organization confers cellular identity and guides cellular functions. Here, the
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Proteomic Analysis of Mammary Epithelial Cell Development
… investigate the protein profile of the mammary epithelial cell (MEC) through different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which represent the pregnant and lactating states of the cells. This …
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Involvement of eicosanoid signalling in epithelial cell migration
… eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell migration a key process in IBD and CC. This was …
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Three-Dimensional Scaffolds for Mammary Epithelial Cell Growth
Mammary epithelial cells are highly efficient secreting cells. This natural phenomenon has triggered research efforts to focus on using these cells to assist in the production of viable liquids. The application of this technology is nearly endless. If developed successfully, mammary epithelial …
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Hypoxia signalling regulates human lung epithelial cell fates
… and how hypoxia directly affects human lung epithelial development. In this PhD thesis, I present my investigation of the effects of chronic hypoxia on the human lung epithelium using organoid models. Human first-trimester lung epithelial progenitors can be isolated from embryonic and fetal …
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In vitro models for airway epithelial cell culture
… of the human airway. Various factors such as the cell model, physiochemical factors such as the cell substrate properties including its stiffness, shear stress, stretch, the air-liquid interface and the biochemical factors in the medium influence the biology of the cells. The aim of this work is …
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Effect of Cell-Substrate Interactions on Epithelial Cell Mechanics
Cell-substrate interactions play a key role in the regulation of epithelial cell mechanics. Through a series of studies, we demonstrate how substrate interactions impact both the response to an oncogene and the cellular contractility and organization of a monolayer. We first examine the effects of …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
… direct differentiation or via a progenitor cell population (Michalopoulos & Khan, 2015). However, the reality of this process in a disease context especially in human remains to be fully demonstrated while the molecular mechanisms involved have not been investigated in detail. Here, I …
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Epithelial Cell Autophagy in Antibacterial Defense of the Small Intestine
… disease (IBD), and bacteremia. As a result, epithelial cell innate immune responses play an essential role in preventing bacterial invasion of host tissues and maintaining a symbiotic host-bacterial relationship. Autophagy is emerging as an important component of innate immunity. Mounting …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… inflammation at the level of intestinal epithelial layer (IEL) remains elusive. To bridge this knowledge gap, the aim of our present study was set in the direction to delineate the effects of n-3 PUFA in porcine IPEC-J2 cell line under (LPS) stress conditions underpinning pig nutrition, …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… In vitro, cyclic strain promotes intestinal epithelial proliferation and induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase (DPPIV) expression. Schlafen 3 is a novel gene recently associated with cellular differentiation. We sought to evaluate whether Schlafen 3 …
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… and the ease with which it can be taken into a cell. Chromate, Cr(VI), ions are taken up by a cell through relatively non-selective anion channels which normally regulate uptake of phosphate and sulfate ions. Once in the cell, chromate ions are reduced by intracellular reductants such as …
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… and the ease with which it can be taken into a cell. Chromate, Cr(VI), ions are taken up by a cell through relatively non-selective anion channels which normally regulate uptake of phosphate and sulfate ions. Once in the cell, chromate ions are reduced by intracellular reductants such as …
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Computational Modelling of Fluid and Ion Transport in the Epithelial Cell
… We developed a mathematical model of a generic epithelial cell to simulate these transport processes. This system can be adapted to model transport across different epithelia - here, it was used to obtain insight into normal and pathological conditions in salivary and alveolar epithelia. …
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Intestinal Epithelial Cell Intrinsic IL-1R Signaling in Host Defense and Inflammation
Pages viii-xix are misnumbered as pages vi-xvii.
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The Role of Short-Chain Fatty Acids on Intestinal Epithelial Cell Migration
… of SCFAs, specifically propionate, on intestinal epithelial cell migration and wound healing. Intestinal epithelial cell migration is critical for epithelial restitution, the first phase in wound healing in the intestine. The studies in this dissertation demonstrated the effectiveness of SCFAs to …
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Imaging studies of glycan mediated breast cancer epithelial cell-endothelial cell interactions
… organs in the body. Aberrant glycosylation of cell surface glycoproteins in cancer cells has been implicated in promoting cancer metastasis and consequent poor survival of cancer patients. In particular, aberrant glycans terminating in α-N-acetylgalctosamine (GalNAc), specifically recognized by …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… demonstrated that in the absence of macrophages epithelial repair after irradiation injury is aberrant, suggesting that macrophages are essential for successful tissue repair in the salivary gland. However, the precise function of macrophages in this process currently remains unknown. Here, I …
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Epithelial Cell Adhesion and Proliferation on Titanium(V) Biofunctionalized with Nanoceramic Thin Film
… were cultured on each treated or untreated disk. Cell viability and adhesion were assessed at 6 and 24 hours via fluorescence microscopy (n=7), and proliferation was measured on days 1, 3, and 6 via colorimetric assay (n=7). Cell morphology was qualitatively examined with scanning electron …
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IN VITRO LUNG EPITHELIAL CELL TRANSPORT AND ANTI-INFLAMMATORY ACTIVITY FOR LIPOSOMAL CIPROFLOXACIN
… that Lipo-CPFX enables slower and sustained lung epithelial transport and uptake, compared to CPFX, thereby producing prolonged local pharmacological actions. The human bronchial epithelial Calu-3 cells were used as monolayers to characterize the kinetics and mechanism of transport and/or uptake, …
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