Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"epithelial and endothelial cells"”.
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Computational Algorithms for Predicting Membrane Protein Assembly From Angstrom to Micron Scale
… perfected through evolution for diverse and unique functions. Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the …
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Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale
… perfected through evolution for diverse and unique functions. Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the …
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Identifying potential binding sites of Nectin 4 for bespoke anti-cancer peptides
Nectin 4 is a cell adhesion protein found between epithelial and endothelial cells during embryogenesis; expression then falls to low levels during adulthood. However, Nectin 4 has also been shown to be over expressed in some of the deadliest/common cancer types of the bladder, pancreas, lung and …
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The Molecular Characterization of Phosphorylcholine (ChoP) on Histophilus somni Lipooligosaccharide: Contribution of ChoP to Bacterial Virulence and Pathogenesis
… somni virulence factors include expression and antigenic variation of lipooligosaccharide (LOS). Phosphorylcholine (ChoP) is often expressed on H. somni LOS and also undergoes antigenic variation. In this study, five genes that play a role in expression and antigenic variation of ChoP, …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… edema, II) excessive pro-inflammatory cytokines and chemokines production from alveolar epithelial and endothelial cells and III) leukocyte migration from blood circulation into alveoli. Currently, there is no FDA approved pharmacological treatment available except the supportive mechanical …
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IGPR-1 promotes colorectal cancer tumor cell survival and modifies the response of cancer cells to chemotherapeutics
… leading cause of cancer-related death in women and fourth in men globally. While expansions in preventative measures have increased the detection of CRC at the early stages of disease, only 40% of CRC patients are diagnosed when the disease is at a local stage. Moreover, many anti-cancer drugs …
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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents
… glaucoma, septic shock, hemorrhagic shock, and cancer. Our research has focused on two major conditions for which cannabinoids hold great promise for drug development, namely, cancer and inflammation.</p> <p>Our focus in the field of cancer has been on the devastatingly lethal brain tumor …
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Clinical Applications of Stem Cells in Ocular Surface Reconstruction.
… current techniques for the ex vivo expansion of epithelial and endothelial cells on amniotic membrane for the treatment of ocular disorders. This thesis is primarily a microscope-based study and documents the findings of several investigations designed to refine tissue engineering of the cornea. …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
A role for cyclooxygenase enzymes and prostaglandins (such as prostaglandin E2) has been observed in benign endometrial pathologies (endometriosis, excessive blood loss and dysmenorrhoea) and in adenocarcinoma. Cyclooxygenase and prostaglandin E synthase enzymes catalyse the conversion of …
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells
… to use this peptide as an immunogen to generate and fully characterise polyclonal rabbit antibodies to the P2Y2 receptor. Other aims of this study were to characterise epithelial and endothelial cells for a thorough expression profile of P2Y receptor mRNA transcripts in order to provide a rapid …
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Analyse des Transkriptionsprofils von Neisseria meningitidis während der Infektion von Epithel- und Endothelzellen unter Verwendung der Mikroarraytechnologie
… Analyse führte zur Identifizierung einer Proteinbande bei 210 kDa, die spezifisch für die NMB1843 negativen Stämme ist. Dieses Protein wurde als nadA identifiziert. NadA induziert im Tiermodell bakterizide Antikörper und gilt daher als möglicher Impfstoffkandidat. Die in dieser Arbeit vorgelegten …