Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2139 for “"epithelial"”.
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Microbial interactions with epithelial surfaces.
Background. Staphylococcus aureus is an important gram positive pathogen that causes a multitude of human diseases. Many of these diseases are associated with the production of staphylococcal exotoxins. Superantigens are a family of staphylococcal exotoxins associated with many of these illnesses. …
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Signal transmission in epithelial layers
… ligand mediated intercellular signaling in epithelial layers, and we study this model under various assumptions. This model is characterized by nonlinear reaction-diffusion type dynamics. The nonlinearities mainly arise at cell layer where feedbacks can be generated through e.g. ligand …
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Collective migration of epithelial sheets
… barriers of the intestinal mucosae, as well re-epithelialization in the healing of wounds. Yet, considering their ubiquity and relevance, the basic origin of the collective motion of sheets has eluded a clear and quantitative interpretation in physical terms, prohibited by the lack of …
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Induction of epithelial to mesenchymal transition in mesothelial cells by secreted factors from uterine epithelial cells
Made available in DSpace on 2012-05-22T00:30:00Z (GMT). No. of bitstreams: 2 Masoud_Farzaneh.pdf: 34313918 bytes, checksum: e99d6869329b04b746cc82321b8f70bc (MD5) license.txt: 4065 bytes, checksum: 032671e283e8d231a619ff8c90294786 (MD5)
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Bioartificial matrices to modulate epithelial morphogenesis
Acute injury of major epithelial organ systems (kidney, liver, lung, etc.) is collectively a principal cause of death worldwide. Regenerative medicine promises to meet these human health challenges by harnessing intrinsic cellular processes to repair or replace damaged tissues. Epithelial …
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Regulatory mechanisms of epithelial sodium channel
Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the regulation mechanism of …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… understanding of the underlying mechanisms. Epithelial-mesenchymal-transition (EMT) is a naturally occurring and strictly regulated trans-differentiation process essential for tissue morphogenesis during early embryonic development. Recent studies suggest that aberrant reactivation of EMT in …
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Characterizing Human Papillomavirus Associated Oral Epithelial Dysplasia
… these lesions. We identified HPV-associated oral epithelial dysplasia (HPV-OED) through screening for histopathological features of HPV and p16INK4a immunoreactivity. Transcriptionally active infections were confirmed by performing RT-qPCR to identify E6 mRNA expression. We identified 82 cases of …
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FUNCTIONAL STUDY OF MAMMARY EPITHELIAL CELL ARCHITECTURE
Cell organization confers cellular identity and guides cellular functions. Here, the
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Immune activation at the lung epithelial barrier
… important role for structural cells, especially epithelial cells, in allergic asthma. Lung epithelial cells express pattern recognition receptors (such as TLR4) and respond to allergens by producing DC-instructing factors. Chapter 5 demonstrates that exposure of lung epithelial cells to HDM leads …
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Targeting epithelial senescence to augment renal repair
… in vivo of the post injury renal epithelial senescent transcriptome at a single-cell resolution, identifying multiple novel therapeutic targets in silico and confirm these targets are upregulated in senescent cells in vitro. Inhibition of two of these targets, Protein Disulfide …
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Active Vertex Model of Epithelial Monolayer Mechanics
… studies of the mechanics of confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible to similar methods is presented. The AVM combines the Vertex Model for confluent epithelial tissues with active matter dynamics. Cell contacts are …
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Development and Maintenance of Thymic Epithelial Microenvironment
… to new antigen. Even though significant thymic epithelial turnover occurs, it is unclear if postnatal thymic progenitors/stem cell are responsible for the maintenance of the TEC microenvironment. Here we use the K5rtTA:TetO-‐H2BGFP transgenic model to identify a slow cycling potential stem …
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Modeling Epithelial Ovarian Cancer In The Mouse
For over five decades epithelial ovarian cancer (EOC) is identified as the leading cause of death from gynecological malignancies in the USA. Unfortunately, due to latent progression of EOC and lack of accurate animal models studies of this disease's pathogenesis have been challenging. Not …
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Proteomic Analysis of Mammary Epithelial Cell Development
… investigate the protein profile of the mammary epithelial cell (MEC) through different stages of mammary development. The HC11 cell line was used to investigate protein changes between undifferentiated and differentiated MEC, which represent the pregnant and lactating states of the cells. This …
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Dissection of CD2AP functions in epithelial cells
… molecular mechanism that determines the shape of epithelial cells. Epithelial cells are characterized by extensive cell-cell contacts along lateral membranes that hold the cells together in cohesive sheets and by a pronounced apical-basal polarity in which the apical domain faces a lumen and the …
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