Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 197 for “"epithelia"”.
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Immunomodulatory effects of LL-37 in the epithelia
… agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by epithelial cells. To investigate the potential of lower …
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Selection and competition of somatic mutations in normal epithelia
Tumourigenesis occurs when a series of genome alterations occur in the same group of cells and cause uncontrolled cell proliferation. Therefore, to understand the journey from healthy to cancerous tissue, it is important to study the accumulation and spread of mutations in pre- cancerous normal …
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Regeneration of Hair Cell Epithelia in the Chick and Salamander
… There are two types of hair cell sensory epithelia based on location: those of the inner ear, such as the organs for hearing and balance, and the lateral line system located within the epidermis. In mammals, including humans, loss or damage of the hair cells of the auditorysystem results …
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Dynamics of Cell Packing and Polar Order in Developing Epithelia
… study of cell packing geometry in developing epithelia. We use a vertex model to describe the packing geometry of tissues, for which forces are balanced throughout the tissue. We introduce a cell division algorithm and show that repeated cell division results in the formation of a distinct …
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Giardia trophozoite-secreted proteins and their effects on intestinal epithelia
Giardia is a major cause of diarrheal disease worldwide. It is a flagellated cyst-forming enteric pathogen that inhabits the lumen of the small intestine. Two genetically distinct lineages (assemblages A and B) are of public health relevance and are often associated with water-borne outbreaks. Yet, …
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Mechanism of Aldosterone Regulation of Sodium Transport in A6 Epithelia
… known to stimulate Na$\sp+$ transport in tight epithelia. The goal of this dissertation was to study the mechanism of aldosterone stimulation of Na$\sp+$ transport through amiloride-sensitive Na' channels (ENaCs) in cell cultured A6 epithelia. Non-invasive methods of blocker-induced noise …
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SELECTION OF TARGETING MOIETIES DRIVING NANOPARTICLE PENETRATION THROUGH SQUAMOUS PLURISTRATIFIED EPITHELIA
Drug delivery through stratified squamous epithelia is crucial for treating various local and systemic conditions. Nevertheless, the administration through these kinds of epithelia, like the skin, the esophageal membrane, and the corneal membrane, poses significant challenges due to their complex …
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Visualization and quantification of autophagy in primary gastrointestinal epithelia cell cultures.
… results from an autoimmune reaction to gut epithelial cells, and this raises the possibility that the risk alleles alter autophagy and/or NOD2-mediated microbial sensing in gut epithelial cells. The aim of this thesis has been to develop methods to quantifying autophagy in primary epithelial …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and function in Ig transport and …
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Regulation of Sodium Transport in A6 Epithelia by Prostaglandin E(2)
… single-channel current (iNa) of apical membrane epithelial Na + channels (ENaCs) in A6 epithelia in response to 1 muM PGE 2 added to the basolateral solution. Epithelia were investigated in both unstimulated (n = 11) and aldosterone-stimulated states of Na + transport (n = 8) where changes of …
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Absorption of carnosine and methionylglycine by sheep ruminal and omasal epithelia
… and transfer across ruminal and omasal epithelia collected from four (carnosine) and seven (methionylglycine) sheep were studied using parabiotic chambers that were repeatedly sampled over a 240-min incubation. The quantity of dipeptide absorbed or transferred was linearly (P < .01) …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the sensory …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… virus mediated transduction of sensory epithelia within the guinea pig cochlea Chairperson: Dr. David J. Poulsen, PhD. Hearing loss is the most common disability of the senses and affects 250 million people worldwide. This condition is often caused by the degeneration of the sensory …
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Role of transient receptor potential channels in mammalian oviduct and uterine epithelia
… thesis is concerned with calcium homeostasis in epithelial tissue lining the oviduct and uterus which are key players in early reproductive events, being involved in gamete transport, sperm capacitation and providing the micro-environment for the gametes and early embryo. Calcium transport across …
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The role of space in homeostasis and preneoplasia in stratified squamous epithelia
… is the dynamics of stem cells in squamous epithelia. Given that most common human cancers develop from epithelia, understanding the rules of cell fate decision in these systems is key to explaining not only healthy tissue growth and maintenance but also the processes of mutagenesis and …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
… profiling time course of regenerating sensory epithelia: SE) in avian cochlea and utricle on a custom transcription factor microarray following damage by laser and chemical ablation and identified genes from known signaling cascades differentially expressed during SE regeneration. In the second …
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Expression Analysis of the Regenerating Utricle Sensory Epithelia : From Macroarrays to Parsing Pathways
… differences in the chicken inner ear sensory epithelia. In the initial study, the sensory epithelium from the utricle was compared to that of the cochlea. The purpose of this study was to identify gene expression differences between these two organs. The sensory epithelium from each organ is …
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Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
… upregulation of CBS in an adenoma-like colonic epithelial cell line (NCM356) is sufficient to induce increased NCM356 cell bioenergetics, proliferation, invasion through Matrigel, resistance to anoikis, and CBS-dependent tumorigenesis in immunocompromised mice. CBS expression enhances cell …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
… into the molecular basis of cell competition in epithelial cells. In this system, silencing of the tumour suppressor scribble (scribKD) results in a ‘loser’ phenotype whereby scribKD cells are specifically eliminated from the monolayer by surrounding wild-type cells. More specifically, scribKD …
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