Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"epistatic"”.
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Epistatic Effects in Corn (Zea Mays L.)
Made available in DSpace on 2014-12-14T14:37:26Z (GMT). No. of bitstreams: 1 7821015.pdf: 2785411 bytes, checksum: f118efa91f24a18705d9fc68721543c1 (MD5) Previous issue date: 1978
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Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits
… genes that show parent-of-origin effects. This epistatic network forms a nutritional responsive pathway and the genes comprising it jointly serve cellular functions associated with growth. While epistatic interactions can explain some of the overabundance of parent-of-origin effects on metabolic …
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Genetic Association Mapping : Missing Markers, Epistatic Effects, and Applications
<p>Association mapping has been widely used to detect desirable genetic markers associated with traits of interest for plant improvement. Missing marker data are a common and yet challenging issue in many association mapping studies, especially as the number of markers used for these studies is …
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Narrowing of the SLES1 Internal Reveals Complex Epistatic Interactions in the Suppression of Autoimmunity
… which have revealed multiple layers of epistatic gene interactions within the Sles1 interval. Phenotyping of a truncated recombinant interval mapped the Sles1 phenotype to an approximately 638 KB segment, which combined with genomic and expression analysis, suggested Btnl2 and the H2 …
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The Additive, Dominance and Epistatic Effects of Six Mutant Genes on Somequantitative Characteristics of Drosophila Melanogaster
Made available in DSpace on 2014-12-05T23:08:00Z (GMT). No. of bitstreams: 1 6202902.pdf: 3721383 bytes, checksum: f12265fd5e782475981e129abf36ef90 (MD5) Previous issue date: 1962
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SAERMA: Stacked Autoencoders Rule Mining Algorithm for the Interpretation of Epistatic Interactions in GWAS of Extreme Obesity
… and association rule mining (ARM) to identify epistatic interactions between SNPs. This is achieved using a case-control dataset containing 2,193 observations (962 cases and 1,231 controls) each with 594,034 genetic markers. A statistical filtering strategy is adopted to reduce the large number …
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Epistasis for agronomic traits in elite maize hybrids
… This study was conducted to determine whether epistatic interactions play a significant role in hybrid performance, whether an epistatic or non-epistatic model satisfactorily explains the variation observed, and whether the selected models are appropriate for detecting epistasis. Statistical …
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High Dimensional Analysis of Genetic Data for the Classification of Type 2 Diabetes Using Advanced Machine Learning Algorithms
… and traits however it neglects the non-linear epistatic interactions that are often present within genetic data. Complex human diseases are caused by the contributions made by many interacting genetic variants. However, detecting epistatic interactions and understanding the underlying …
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Mitochondrial Contributions to Schizophrenia Symptom Severity: A GWAS Approach in a South African Population
… cumulative mitochondrial gene burdens, and epistatic interactions between mitochondrial SNVs and nuclear-encoded mitochondrial genes (NEMtGs) against Positive and Negative Syndrome Scale (PANSS) scores. Although no associations survived multiple testing corrections, exploratory analyses …
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Microsatellite polymorphism, orthologous evolution and molecular marker analysis of seed quality traits in soybean (Glycine max L. Merr.)
… interactions identified three significant epistatic interactions in both generations. In a combined analysis, the significant marker loci and epistatic interactions explained 50 and 60% of the total variation for seed weight in the F₂ and F<sub>2:3</sub> generations, respectively. …
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Multi-omics Investigation into Alzheimer's Disease: Functional Mechanism and Early Detection
… aim, I took a step further and hypothesized the epistatic effect of GWAS findings and neighboring variants on the downstream functional mechanism. Leveraging the recent advances in sequence-based genome annotation, I investigated the tissue-specific effects of top AD GWAS variants on the …
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Genetic architecture of reproductive and growth traits in laboratory mice
… the relative importance of additive, dominance, epistatic, maternal and sex-linkage effects for reproduction and growth traits in mice. Two selected lines of mice, extremes in phenotype for gain from 21 to 42 days of age, were used in a triple test cross design. The high line had completed 24 …
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Genetic and biochemical interactions between the DNA replication initiator and a chromosome architecture protein in Bacillus subtilis
… the co-association, in vitro interaction, and epistatic relationship between the DNA replication initiator DnaA and the nucleoid-associated protein Rok in Bacillus subtilis. Using ChIP-seq, I characterized the genome-wide association of DnaA and its regulator YabA. I found that DnaA and YabA …
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Epistasis and Other Factors Influencing the Detection of Marker-Qtl Associations
… marker loci from the two mapping populations, epistatic interactions between QTL, inaccurate marker-QTL associations due to epistasis and low trait heritabilities, and sampling bias.
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Characterizing Deleterious Genomic Mutations in Simulated Populations Under Some Biologically Realistic Situations
… was implemented under constant, variable and epistatic mutation effects. I find that generally the estimation by the DENG-LYNCH method is fairly robust if the selfing rate (S) is less than 0.10 in outcrossing populations and if5 >0.8 in selfing populations. The estimation may be unbiased under …
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Genetic Control of Experimentally Induced Reproductive Autoimmune Phenotypes
… interactions between QTL, and the importance of epistatic interactions between genes in reproductive autoimmunity and immunoregulation.
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Inheritance of virulence in the root rot pathogen Phytophthora sojae
… silencing is strain specific and could rely on epistatic factors. This study will lead to a better understanding of infection and virulence mechanisms that will help to better manage and safeguard soybean production.
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ΓΕΝΕΤΙΚΟΙ ΠΑΡΑΜΕΤΡΟΙ ΤΟΥ ΒΑΘΜΟΥ ΑΛΚΑΛΙΚΟΤΗΤΑΣ ΤΗΣ ΥΔΑΤΟΔΙΑΛΥΤΗΣ ΤΕΦΡΑΣ ΣΤΑ ΕΛΛΗΝΙΚΑ ΚΑΠΝΑ (N. TABACUM L.)
… FOR THE MAIN GENETIC EFFECTS AND THREE FOR THE EPISTATIC.THE LEAST SQUARE PROCEDURE WAS APPLIED TO DETERMINE THE PARAMETERS BEST FITTING THE MODEL. RELATED CHEMICAL CHARACTERISTICS (ASH %, CA %, MG%, K%, AND COMBUSTIBILITY) WERE ALSO ESTIMATED AND CORRELATION COEFFICIENTS WERE OBTAINED. ADDITIVE …
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Stochastic simulation of a selection experiment in maize
… effects, and the remaining two subgenotypes are epistatic. In the simulation program, the genotype consists of 100 loci on 10 pairs of chromosomes, which contribute to the genotypic value according to the gene action models used. Each run begins with the F₁ hybrid of two unrelated inbred …
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Steady states in rapidly evolving populations
… sizes. We consider a range of fitness-mediated epistatic interactions and the corresponding implications regarding the existence, location and stability of long-term evolutionary fixed points.
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