Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"epistasis"”.
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Epistasis in Predator-Prey Relationships
<p>Epistasis is the interaction between two or more genes to control a single phenotype. We model epistasis of the prey in a two-locus two-allele problem in a basic predator- prey relationship. The resulting model allows us to examine both population sizes as well as genotypic and phenotypic …
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Pleiotropy and epistasis in auxin signaling networks
Plant hormones and their gene regulatory networks orchestrate a diverse array of metabolic and physiological changes crucial for growth, development, and environmental responses. Targeting the engineering of hormone signaling networks holds promise for enhancing plant health, crop productivity, and …
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The Potential Power of Dynamics in Epistasis Analysis
… One classical approach to this problem is epistasis analysis. Broadly speaking, epistasis analysis infers the regulatory relationships between a pair of genes in a genetic pathway by considering the patterns of change in an observable trait resulting from single and double deletion of …
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Epistasis for agronomic traits in elite maize hybrids
… selected models are appropriate for detecting epistasis. Statistical epistasis was measured with a modified generation means model using testcrosses. The non-epistatic model included components for the main effect and an additive effect. In addition to these terms, the epistatic model included …
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RaSaR: A Novel Methodology for the Detection of Epistasis
… of Breast Cancer; unknown, in-situ and invasive. Epistasis is a progressive approach that complements the ‘common disease, common variant’ hypothesis that highlights the potential for connected networks of genetic variants collaborating to produce a phenotypic expression. Epistasis is commonly …
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Pervasive degeneracy and epistasis in a protein-protein interface
Signal transduction pathways rely on transient yet specific protein-protein interactions. How a limited set of amino acids can enforce cognate protein interactions while excluding undesired pairings remains poorly understood, even in cases where the contacting residues have been identified on both …
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Walsh analysis, epistasis, and optimization problem difficulty for evolutionary algorithms
The epistasis of a function is the bitwise nonlinearity of a function whose domain is the set of bit strings of length L. Epistasis is related to problem difficulty for evolutionary algorithms. Walsh analysis can be used to quantify epistasis. In this dissertation Walsh analysis is developed in …
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Evolution, epistasis, and the genotype-to-phenotype problem in Myxococcus xanthus.
… the phenotypes of additional mutation through epistasis. This is an ongoing phenomena in M. xanthus; whole genome resequencing of several inter-laboratory isolates of M. xanthus wild type DK1622 reveals genomic variation that has resulted in significant phenotypic variation. We demonstrate that …
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Epistasis and Other Factors Influencing the Detection of Marker-Qtl Associations
… QTL, inaccurate marker-QTL associations due to epistasis and low trait heritabilities, and sampling bias.
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The Structural Distribution of Epistasis in a Pair of Essential Metabolic Enzymes
… This context-dependence of mutational effects is epistasis. Extensive progress has been made in our ability to identify epistasis between proteins. However, how the epistasis between a pair of proteins is distributed across the amino acid sequence is less clear. Previous work characterized this …
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Dissecting mechanisms of intersegment epistasis and its role in influenza A virus biology.
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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EXAMINATION OF THE CONTRIBUTION OF DIFFERENCES IN DISEASE ARCHITECTURE AND EPISTASIS TO TYPE 2 DIABETES RISK IN AFRICAN AMERICANS
Diabetes is a major global health problem. In the United States alone, 29.1 million people, or 9.3% of the population, have diabetes. Type 2 diabetes (T2D) is the most common form of the disease and represents 90-95% of all diagnosed cases. This form of the disease is characterized by high blood …
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Functional variation in the mitochondrial genome of the yeast saccharomyces cerevisiae
… relevant conditions consistent with negative epistasis between mitochondrial loci (mito-mito epistasis). I generated recombinants between mitotypes from various populations and found significant estimates of mito-mito epistasis affecting growth that were more frequently negative in sign. …
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On Methods for Detecting Linkage from Analysis of Genetic Covariance
… for a two-locus model with both linkage and epistasis. From analysis of this general expression, epistasis was found to mimic the effects of repulsion linkage. Furthermore, the use of an approximate expectation for variances and covariances m Gates' test caused an upward bias in both additive …
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Genetic Association Mapping : Missing Markers, Epistatic Effects, and Applications
… of several sets of DNA markers with potential epistasis associated with target traits will greatly help plant improvement via a marker assisted selection approach. In this study, we first proposed a linkage-based imputation method for missing marker data given available linkage information and …
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Models and methods for computer simulations as a resource in plant breeding
… regression, with versions for traits with no/low epistasis, pRKHS-NE, to high epistasis, pRKHS-E. Compared to RR-BLUP, BayesA, BayesB, and RKHS, pRKHS delivers greater predictive ability, particularly when epistasis impacts expression in the trait of interest. Beyond prediction, the new method …
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Genomic Association Screening Methodology for High-Dimensional and Complex Data Structures: Detecting n-Order Interactions
… Irrespective of the trait under consideration, epistasis screening methodologies such as MB-MDR and MDR mainly suffer from the presence of phenotypic mixtures and genetic heterogeneity. Secondly, we extensively addressed the issue of adjusting for lower-order genetic effects during epistasis …
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Investigating the Roles of the Stk Locus in Development, Motility and Exopolysaccharide Production in Myxococcus Xanthus
… no obvious effects on EPS production. Genetic epistasis suggests that StkA functions downstream of TFP and upstream of the Dif sensory proteins in EPS regulation in M. xanthus. Epistasis analysis involving stkB was inconclusive. It is unresolved whether StkB plays a role in the biosynthesis or …
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Rationalising and accelerating enzyme engineering by quantitative sequence-function profiling in microdroplets
… protein engineer to navigate complex intra-gene epistasis. Using this workflow, we generate a large-scale sequence-function dataset describing an imine reductase - an enzyme class with broad application in industrial biocatalysis - and rationally engineer improved variants with an up to 11-fold …
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Bayesian Kernel Models for Statistical Genetics and Cancer Genomics
… genetic vari- ants that are involved in epistasis without the need to identify the exact partners with which the variants interact. We refer to this method as the "MArginal ePIstasis Test", or MAPIT. Here, we develop the theory of these two approaches, and demonstrate their power, …
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