Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 398 for “"epigenetics"”.
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Clinical epigenetics of Mendelian neurodevelopmental disorders
Contains fulltext : 311851.pdf (Publisher’s version ) (Open Access)
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Molecular Epigenetics in Evolution and Development
… Using results from recent work in molecular epigenetics, I consider the evolutionary implications for these traits, and show how current models of evolution fail to accurately capture this influence. In doing so, I also address some of the philosophical implications for how we conceptualize …
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The Epigenetics of Small Cell Prostate Cancer
<p>Small cell prostate cancer (SCPC) is an androgen receptor (AR) negative variant that can develop during the progression of castration-resistant AR-positive (AR<sup>+</sup>) prostate adenocarcinomas. While rare at initial diagnosis, SCPC is present in 10-20% of patients resulting in an aggressive …
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Epigenetics and sex expression in trioecious papaya
Sex determination in papaya is regulated by a pair of recently evolved sex chromosomes. Genomic and genetic studies over the past century have made significant achievements towards the understanding of the sex determination system in papaya. However, the epigenetic aspects of sex determination and …
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Technology development in mouse genetics and epigenetics
The importance and significance of a model organism in biological research cannot be overstated. The mouse in particular has been very useful in understanding questions in many areas of research such as developmental biology, cancer biology, neuroscience and genetics. However, even though the …
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Role of epigenetics in hematopoietic stem cell development
In 2106, there were 171,550 new cases of blood cancers and over one million people in the United States living with one of these disorders. Bone marrow transplants have good outcomes, but these procedures require a donor who is a perfect match, and thus many patients are unable to receive …
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Histone modification and the epigenetics of X chromosome inactivation
Dosage compensation serves to equalise the levels of X-linked gene products between males and females. In mammals this occurs through the transcriptional silencing of the majority of the genes on one of the two female X chromosomes. The inactive X chromosome (Xi) differs from its active homologue …
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Investigating Epigenetics as a Mechanism to Regulate Bacterial Heterologous Expression
Epigenetic DNA methylation in bacteria is involved in phage defense, and it can also affect gene transcription. Epigenetic methylation as part of restriction-modification systems is frequently considered a barrier in synthetic biology since it can prevent the introduction of heterologous genes to …
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The effect of age on human monocyte epigenetics and function
As an individual ages their immune system undergoes a series of cellular, transcriptional and epigenomic changes. Using RRBS and RNA-Sequencing data collected from a group of 46 healthy participants across an age range, bioinformatics techniques were used to characterise the effect of age on the …
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Strategies for targeting cancer: small molecules, epigenetics and drug design
… interactions, metallocage drug delivery, epigenetics and protein activity inhibition. The first part of my research focused on the significance of Cisplatin as a chemotherapeutic. My findings indicate the unexpected speciation of platinum in the human body as a revelation to be utilized in …
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
… of what genes are expressed is dictated by epigenetics. Epigenetics is the punctuation of our genetic code. It leaves unique marks that are read, written, and erased on DNA and on histone protein, which package our DNA. The writing and erasing of epigenetic marks requires metabolic products …
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The epigenetics and role of Dopa Decarboxylase in heart development
Genomic imprinting in mammals subjects a handful of genes to silencing on one allele depending on the parent-of-origin of that allele. The Ddc_exonla gene transcript is under the control of genomic imprinting in the developing and neonatal mouse heart with transcription occurring solely on the …
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The chromatin landscape of barley: gene expression, evolution and epigenetics
Barley (Hordeum vulgare) is an economically important crop species with a large diploid genome. Around a half of the barley genome and a fifth of the genes are constrained within a low-recombining pericentromeric (LR-PC) region. I explored the LR-PC gene component with a genomic investigation of …
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Proximate And Evolutionary Insights Into The Epigenetics Of Posttraumatic Stress Disorder
<p>Posttraumatic stress disorder (PTSD) is an important medical and social condition. Although the vast majority of individuals are exposed to traumatic events within their lifetime, a minority subsequently develop diagnosable PTSD. What underlies differential risk and resiliency in the face of …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers that affects genes known to have important roles in several aspects of cell biology. Hematological malignancies have been reported to harbor multiple genes aberrantly silenced by promoter …
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Biomechanical regulation of epigenetics and chromatin organization in single living cells
… questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and …
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3D Chromatin Structure and Gene Regulation: Integrated Genome Structure, Transcriptomics and Epigenetics
The three-dimensional (3D) organization of the genome is essential for regulating gene expression, replication, and stability. Chromatin folding mediates enhancer–promoter communication, but bulk Hi-C data obscure single-cell variability, while sparse single-cell Hi-C limits structural resolution. …
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Unsettling epigenetics: contested understandings of trauma and evidence in settler colonial Australia
… intergenerational trauma through environmental epigenetics has become a highly contested space within Indigenous health research in settler colonial Australia. Intergenerational trauma is a popular model for understanding how colonial and racist policies have had, and continue to have, …
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Ocean acidification influences on physiology and epigenetics in the Pacific oyster (Crassostrea gigas)
As ocean acidification continues to impact marine ecosystems at unprecedented rates, phenotypicplasticity may allow organisms to withstand more stressful conditions. Genomic methods can elucidate molecular mechanisms that contribute to phenotypic plasticity, allowing for a deeper understanding of …
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