Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"epigenetic reprogramming"”.
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Cloning, stem cells and epigenetic reprogramming after nuclear transfer
… transfer (NT) experiments have demonstrated the epigenetic nature of development and showed, that although differentiated cells have a very limited developmental potential, the nuclei of these cells retain the potency to direct embryogenesis after reintroduction into the unfertilized oocyte. …
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Novel Roles of the Aryl Hydrocarbon Receptor in Normal Physiology and Epigenetic Reprogramming
… 34 (H1K34hcit). Homocitrullination, a novel epigenetic mark, was observed only in response to exogenous AhR agonists and is absent upon treatment with endogenous AhR ligands such as cinnabarinic acid. Results presented here demonstrate AhR-CPS1 dependent H1K34hcit is associated specifically …
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LINKING HISTONE LACTYLATION TO THE EPIGENETIC REPROGRAMMING OF CD4+ T REGULATORY LYMPHOCYTES IN THE TUMOR ECOSYSTEM
… and invasion. TI-Treg are transcriptionally and epigenetically adapted to the hostile tumor microenvironment (TME), which is characterized by nutrient- deprivation, hypoxic conditions and accumulation of lactic acid. Here we describe our findings on epigenetic and metabolic reprogramming of …
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The roles of DPPA2, DPPA4 and SMARCA5 in mouse zygotic genome activation, epigenetic reprogramming and development
The epigenetic remodelling that takes place in order to transform a fertilised oocyte into an embryo and then a whole organism, is one of the most intriguing cellular transformations in biology. The whole process starts with the meiotic resumption of an oocyte when the translational activation of …
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The core mammalian pluripotency network in induced pluripotent stem cell (iPSC) formation : models for genetic and epigenetic reprogramming
… gene regulatory network being awakened in iPSC reprogramming. Using these modeling insights, I discuss the merits of current reprogramming strategies, which can be viewed as open-loop perturbations in control theoretic terms. I then discuss an alternative paradigm of closed-loop reprogramming, …
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Role of small RNAs and chromatin in transposable element silencing during global demethylation
… cells. Global hypomethylation is a hallmark of epigenetic reprogramming in mammalian primordial germ cells (PGCs), the early embryo and in naïve embryonic stem cells (ESCs). Genome integrity is crucial during early development, as the germline DNA needs to be protected for future generations. …
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Dynamic epigenetic modifications during human fetal germ cell development
… significance of normal germ cell development. Epigenetic modifications, which modify gene expression without changing the underlying DNA sequence, can affect the fate of germ cells. Abnormal epigenetic reprogramming will facilitate abnormal germ cell development; therefore, understanding of …
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
… responsible for the transmission of genetic and epigenetic information (the instructions to make new life) from one generation to the next. It is therefore, of paramount importance that germ cells maintain the stability of their genome. Failure to do so can result in the transmission of de novo …
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The Regulation of UHRF1 during Mammalian Embryogenesis
… expression, it is not yet understood why this epigenetic reprogramming is so extensive. Recent research has revealed that multiple different examples of global demethylation are orchestrated by regulation of UHRF1, which recruits the maintenance methyltransferase DNMT1 to newly replicated DNA. …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic stroma, which is largely composed of cancer-associated fibroblasts (CAFs). Distinct populations of CAFs, including inflammatory …
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Epithelial Memory of Resolved Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis
… associated with sustained transcriptional and epigenetic reprogramming. Such adaptation enables the prompt reactivation of acinar-to-ductal metaplasia (ADM) upon subsequent inflammatory events, thus efficiently limiting tissue damage <em>via</em> rapid decrease of zymogen production. We propose …
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Programming of cardiovascular disease: an exploration of epigenetic mechanisms
… fetal germ cells, which form sperm in adulthood. Epigenetic reprogramming of germ cells is characterised by the genome-wide erasure and subsequent re-establishment of 5-methylcytosine (5mC), however this process has not previously been described for the rat. Furthermore, the involvement of more …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… PSA-/lo cells possess intrinsic molecular and epigenetic features that regulate their aggressiveness and stemness and contribute to tumor progression and therapy resistance, and that these properties can be gained through epigenetic reprogramming of more differentiated PSA+ PCa cell population. …
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Oncolytic viruses enhance long-term NK cell anti-tumor cytotoxicity through AP-1 and IRF pathway activation
… the IRF family of transcription factors through epigenetic reprogramming. Overall, this study provides critical insights into the mechanisms driving sustained NK cell cytotoxicity in response to oncolytic viral infection of tumor cells and highlights the potential of this combinatorial approach …
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Transdifferentiation of fibroblasts to neural stem cells
… is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogram a differentiated cell!s nucleus to one that is …
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Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
… small molecule modulator (ZL0580) that induces epigenetic suppression of HIV. Here, we examined the effects of this compound on HIV in human myeloid cells. We found that ZL0580 induces potent and durable suppression of both induced and basal HIV transcription in microglial cells (HC69) and …
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Microbiota-host interactions and infection dynamics in critical illness.
… though “mis-trained immunity” via metabolic and epigenetic programming. Taken together, these findings further establish intestinal dysbiosis in critical illness as a driver of neutrophil dysfunction, with metabolic and epigenetic reprogramming of neutrophils as a mediator of immune dysfunction. …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
Epigenetic reprogramming and chromatin structure guide differentiation and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… this is a unique subgroup harboring aberrant epigenetic phenotype. Firstly, DNA methyltransferase (DNMT) inhibitor treatment induced profound DNA hypomethylation in vivo, but minimal change in gene expression due to adaptive elevation of the repressive histone methylation, H3K27me3, leading to …
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Exposures and the Impacts on the Epigenome that Persist from Youth to Adulthood and Intergenerationally
… a plethora of exposures exist, the mechanisms of epigenetic destruction are unique with each exposure. My research explores two exposures, arsenic and the chemotherapeutic drug 5-aza-2'-deoxycytidine (Decitabine), both of which disrupt different elements of the DNA methylation pathway resulting in …
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