Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"epigenetic phenomena"”.
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Statistical power for RNA-seq data to detect two epigenetic phenomena
<p>Epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changing the underlying DNA sequence. Two epigenetic phenomena, genomic imprinting and Allelic Expression Imbalance (AEI), are discussed in this dissertation. RNA-seq is a …
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RNA EXPORT FACTOR ELF1 MAINTAINS GENOME STABILITY IN FISSION YEAST
… frequent mutations, rather than prions or other epigenetic phenomena, cause the phenotype switching. This suggests Elf1 is required to maintain genome stability. Since RNAs accumulate in the nucleus of elf1Δ cells due to an RNA export defect, I hypothesized that excess RNAs in the nucleus may …
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Establishment of the epigenetic landscape in mammalian embryonic stem cells
… development. Deciphering the details of such epigenetic phenomena has the potential to enrich both stem cell biology and therapeutics, as well as offer insight into various pathologies. While the enzymatic machinery responsible for these transitions is well known, it is their localization to …
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Small RNAs within the developing seed of Arabidopsis thaliana
… thaliana exhibits a wide range of dynamic epigenetic phenomena, but relatively little is known about the small RNA (sRNA) populations found within the tissues composing the seed. We set out to profile the sRNA complement found within whole seeds and the embryo and endosperm tissues within …
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Defining the essential regulators of naive human pluripotent stem cell reprogramming
… biology and developmentally-regulated epigenetic phenomena in vitro. Naïve PSCs also have an expanded differentiation potential to produce cell types with possible therapeutic applications. Naïve PSCs are predominantly generated by reprogramming primed PSCs. This project aimed to …
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Purification and Characterization of a Methyl-DNA Binding Protein Complex from Primary Erythroid Cells
The chicken embryonic β-type globin gene, ρ, is silenced on day five of embryogenesis. Concomitant with this silencing is methylation of cytosine residues in the promoter and proximal transcribed region of the gene, which is first detected on day seven and is complete in adult cells. Once …