Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"epigenetic marks"”.
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The potential of epigenetic methods to provide evidence of torture
… and psychological methods that do not leave marks on the body. Providing evidence of these types of torture is often a challenge. Finding biological markers of torture would potentially contribute to solve this problem.
 Methods: Scientific literature review.
 Results: Methods to …
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Small RNA and genome interactions in Chlamydomonas reinhardtii recombinants
… thought to be the root cause of their formation. Epigenetics modifications, heritable variation separate to the DNA code, can alter gene expression, persist through generations, and vary between individuals and over time. This makes them ideal candidates to be involved in the formation of …
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The Role of Metabolism and Epigenetics in Regulating Cellular Plasticity
… of what genes are expressed is dictated by epigenetics. Epigenetics is the punctuation of our genetic code. It leaves unique marks that are read, written, and erased on DNA and on histone protein, which package our DNA. The writing and erasing of epigenetic marks requires metabolic products …
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Computational methods for analyzing and modeling gene regulation and 3D genome organization
… regions by integrating gene expression and epigenetic marks with 3D interactions using network analysis.
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The involvement of non-B DNA forming sequences in mediating missense mutations, micro-deletions and micro-insertions in human inherited disease
… mononucleotide runs and tandem repeats) and epigenetic marks in mediating germline missense and nonsense mutations, micro-deletions and micro-insertions causing human inherited disease and obtained from Human Gene Mutation Database (HGMD; http://www.hgmd.org) was studied in silico. A novel …
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THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS
Epigenetic reprogramming and chromatin structure guide differentiation and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated …
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On the physics of intranuclear organization
… into chromatin is mediated by phase separation. Epigenetic modifications of histone proteins, which DNA wraps around to form nucleosomes, are key determinants of nucleosomes’ condensability and chromatin’s higher-order structure. Chromatin structure, by regulating access of transcriptional …
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Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
… forces cells to lose their lineage-specific epigenetic marks and become totipotent again. This reprogramming process often results in epigenetic and transcriptional aberrations that compromise development. Development rates after SCNT can thus serve as a functional assay for genome-wide …
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DISCOVERY OF NOVEL EPIGENETIC MECHANISMS OF CARCINOGENESIS BY GENOME-WIDE PROFILING OF NON-CODING REGULATORY ELEMENTS
Epigenetic mechanisms are of paramount importance in cancer. Historically, epigenetic studies of cancer have focused on aberrant DNA methylation events. Far less is known about the role of histone modifications in epigenetic mechanisms of human cancers, and of disease in general. There are a number …
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Genomic and microscopic dissection of large-scale chromatin compaction
… with nearby enrichment of active chromatin marks, enhancers and especially super-enhancers, and cohesin and CTCF binding sites. They map closely to a large fraction of genome organization domain boundaries identified by Hi-C, LAD/innerLAD boundaries defined by lamin B1 DamID, and rapid …
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Investigating the impact of pharmacological exposures on the developing epigenome
Epigenetic processes are important for establishing and maintaining cell-type-specific and dynamic gene expression patterns. Genomic imprinting is an epigenetic process found in eutherian and metatherian mammals, which results in parent-of-origin specific expression. There are currently over 100 …
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Small RNAs within the developing seed of Arabidopsis thaliana
… thaliana exhibits a wide range of dynamic epigenetic phenomena, but relatively little is known about the small RNA (sRNA) populations found within the tissues composing the seed. We set out to profile the sRNA complement found within whole seeds and the embryo and endosperm tissues within …
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Einfluss von Histonmodifikationen auf die gewebespezifische Transkription C 4-spezifischer Gene in Mais (Zea mays)
… In the last part of the thesis, allele-specific epigenetic modifications were investigated. By this, an explanation for the earlier described repressive epigenetic marks (H3K9me2 and DNA-methylation) on the active Pepc-gene was identified: The maize genome harbours multiple copies of …
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New Insights On The Role of Jmjd2A In Cancer Progression
… Histone methylation is one of the most intricate epigenetic marks because it adds multiple layers of modification on the targeted sites. Therefore, many studies have brought histone methylases and demethylases into focus, hoping to decipher their roles in cancer progression. Among these enzymes, …
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Unlocking Compacted Heterochromatin Through Modulation Of Associated Proteins
… complex system of gene regulatory complexes and epigenetic marks which promote activation of cell-type specific gene expression profiles and silence alternative cell fate genes. However, the mechanism by which specific genomic loci are silenced in different cell types is still not well …
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Investigating the chromatin dynamics that underlie CRISPRi-validated enhancer-promoter interactions
… through mass detection of genome wide epigenetic marks, chromatin conformation, chromatin accessibility, and expression data. Nevertheless, the process of validating enhancer targets remained costly until recent developments of CRISPRi methods enabled large scale perturbation …
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Programming of the paternal nucleus for embryonic development
… in the embryo with a certain combination of epigenetic marks in the sperm, but not in the spermatid chromatin. Finally, it is shown that enzymatic removal of epigenetic modifications at fertilisation leads to misregulation of gene expression. This therefore suggests that epigenetic …
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Mechanisms and functional significance of nuclear compartmentalization
… regulate the overall balance of specific epigenetic marks and peripheral gene targeting.
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Regulation of nucleosome dynamics
… mean for gene regulation by genomic sequence and epigenetic modifications. Understanding the physical basis of how sequence and epigenetic modifications of DNA affect nucleosome dynamics and nucleosomal DNA exposure will help elucidate how genomic and epigenetic modifications regulate cellular …
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Characterization of DNA methylation and gene expression profiles in post-traumatic stress disorder
… of African ancestry, and to identify regulatory epigenetic marks that putatively regulate leukocyte gene expression in PTSD. Chapter 5 provides a discussion of the implications of these findings and their contributions to the existing PTSD literature. This work uses genomic approaches to generate …
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