Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"epigenetic inheritance"”.
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Transgenerational epigenetic inheritance via environmental stress in Caenorhabditis elegans
<p>No abstract available</p>
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… the Avy allele exhibits transgenerational epigenetic inheritance, susceptibility to environmental exposures, and strain-specific modulation. A recent screen conducted in the C57BL/6J mouse strain identified a subset of IAPs that show variable methylation levels across genetically identical …
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Transgenerational Plasticity is Sex-dependent and Persistent in Yellow Moneyflower (Mimulus guttatus)
… that they differ in the proximate mechanism of epigenetic inheritance. Our results also indicate that a wounding response can persist for multiple generations in the absence of subsequent damage.
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Development of a TIRF Microscope for Single Molecule Binding Studies
… nucleosome assembly to contribute to epigenetic inheritance. The microscope measures fluorescence following total internal reflection (TIR) to accomplish single molecule imaging (SMI). TIR provides a high signal-to-noise ratio (SNR) by generating a hundred-nanometer-thick evanescent …
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Tracing clonal cell plasticity in the microenvironment of pancreatic ductal adenocarcinoma
… fluctuation analysis detecting lineages with epigenetic inheritance of cell states. Altogether, epitope barcoding and cyclical imaging form a compelling experimental strategy for investigating the clonality of transdifferentiation in the microenvironment of pancreatic cancer.
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Keeping It Together and Taking It Apart: Structural Investigations of Replisome Complexes Involved in DNA Replication Fork Protection and Termination
… factors required for cohesion establishment and epigenetic inheritance. Second, I discuss structural insights into the regulation of replisome disassembly as the final stage of DNA replication, presenting the first structure of a replisome complex which has translocated onto double-stranded DNA …
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DNA Methylation and Genetic Divergence Associated with an Inducible Defensive Response in Mimulus guttatus
… trichome production. Results indicate that epigenetic inheritance of the damage response in a particular RIL is associated with 59 differentially methylated regions. Relevant functions, including anatomical structure development and response to abscisic acid, are significantly …
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piRNA-dependent transcriptional gene silencing during Drosophila oogenesis and embryogenesis
… of the cell resulting in changes of the epigenetic chromatin state, thus shutting down transcription. However, whether Panx acts on its own or if other proteins are involved in piRNA-dependent TGS remains unknown. During my PhD I studied the protein-protein interactions of Panx and …
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Large replisome-dependent heterochromatic domains defining the transgenerational regulatory landscape
… in the puzzle to understanding transgenerational epigenetic inheritance (TEI) is a mechanism that allows epigenetic information to be stored and propagated, not only from one generation to the next, but across cell division. Histone modifications, along with small RNAs (sRNA) and DNA methylation, …
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Characterisation of the (H3-H4)2-tetramer and its interaction with histone chaperones
… such as transcription, chromatin replication and epigenetic inheritance. In this study we employ novel biochemical and biophysical techniques to address two key questions in the field: the structure of the soluble (H3-H4)2-tetramer, and the conformation of H3 and H4 in complex with histone …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… approximately half of the mammalian genome. Epigenetic mechanisms evolved to repress these potentially deleterious mobile elements. However, such elements can be variably silenced between individuals – so called ‘metastable epialleles’. The best known example is the Avy locus where an …
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The role of cellular memory modules in the determination and transdetermination of Drosophila melanogaster imaginal disc cells
… experiments suggest that the chromatin-based epigenetic inheritance of gene expression involving CMMs may be widely spread. This implies that during imaginal disc patterning, the determination of a morphogenetic field is not only established by the surrounding combinations of signaling …
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Silencing Through Heterochromatin Formation: The Role of Piwi in Transposon Targeting
… question. Models involving small RNAs, epigenetic inheritance of histone modifications, DNA binding proteins targeting specific motifs, and other mechanisms have been proposed.</p><p>Small RNA targeting of heterochromatin formation is an established mechanism in fission yeast: …
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Unsettling epigenetics: contested understandings of trauma and evidence in settler colonial Australia
… intergenerational trauma through environmental epigenetics has become a highly contested space within Indigenous health research in settler colonial Australia. Intergenerational trauma is a popular model for understanding how colonial and racist policies have had, and continue to have, …
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Investigating the Epigenetic Mechanism Behind Transgenerational Inheritance in Mice with Abnormal Folate Metabolism
… focuses on a mouse model of transgenerational inheritance in which folate metabolism is disrupted by a mutation in Methionine synthase reductase ($\it{Mtrr^gt}$). Remarkably, $\it{Mtrr^+/gt}$ heterozygosity leads to an increased likelihood of a wide spectrum of congenital malformations in their …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
… widely cited as the best examples of mammalian epigenetic inheritance. A recent screen in the C57BL/6J mouse strain identified over 100 candidate VM-IAPs providing novel insights into metastable epialleles. In this thesis, I revisit the phenotypic and epigenetic heritability associated with the …
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Genome-Wide Dynamics of Chromatin Maturation Following DNA Replication
… behind the replication fork to re-establish the epigenetic state of the cell. Many of the factors and mechanisms regulating DNA replication and chromatin assembly have been identified from elegant in vitro biochemical experiments, work in model systems like Saccharomyces cerevisiae, or novel …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… with a focus on sex-specific susceptibility, epigenetic alterations, and lineage-dependent inheritance patterns. In the first study (Chapter 2), adult zebrafish were exposed to environmentally relevant dietary arsenic concentrations (30, 60, and 100 µg/g dry weight, as arsenite) for 60 days. A …
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Multigenerational effects of abnormal folate metabolism on embryo growth and development
… mouse line is a model of transgenerational epigenetic inheritance since the congenital malformations persist at least up to four wildtype generations after an Mtrr+/gt maternal grandparent. In contrast, the growth phenotypes only appear until the F2 generation and have been attributed to an …
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Intergenerational and Transgenerational Effects of Endocrine Insults
… of acquired traits to descendants. Such inheritance may be intergenerational or transgenerational, the latter describing effects that persist in the absence of any exposure (either directly or of parental germ cells) to the triggering environment. Numerous reports of non-genetic …
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