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Showing 1 to 6 of 6 for “"epigenetic dynamics"”.

  1. IDENTIFICATION OF CANCER- AND METASTASIS-RELATED EPIGENETIC DYNAMICS USING PATIENT-DERIVED ORGANOIDS

    BORDO, ROBERTAUniversità degli Studi di Milano2024

    … mutations. This suggests that cells might be epigenetically reprogrammed to undergo those phenotypic alterations. Regarding this, enhancers are crucial since their activation is tightly cell-type-specific. Accordingly, we have recently identified a group of enhancers selectively activated in …

    milano Repository record

  2. 17β-Estradiol induces epigenetic dynamics in T helper 17 and regulatory T cells in vitro and in multiple sclerosis patients during pregnancy

    Cutrupi, Santina, Iannello, AndreaUniversità degli Studi di Torino2019

    unito Repository record

  3. Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons

    Stoyanova, Elitsa

    <p>While epigenetic dynamics in mitotic differentiating cells have been characterized in depth, little is known about how postmitotic neurons regulate their chromatin state. Modulation of transcription through the regulation of accessibility of transcription factor binding sites is essential for …

    rockefeller Repository record

  4. Pioneer Factors Compete for Epigenetic Factors in Switching Stem Cell Fates

    Yang, Yihao

    … to re-activate SOX9 in adult EpdSCs. Combining epigenetic, proteomic, and functional analyses, I interrogated the ensuing transcriptional and epigenetic dynamics, slowed temporally by the mature EpdSC niche microenvironment. My findings demonstrate that SOX9 plays a dual role in the …

    rockefeller Repository record

  5. APPROACHING DNA METHYLATION AT THE NANOSCALE

    Cui, Yi

    Epigenetics involves a variety of biochemical modifications occurring on chromatin that are able to regulate and fine-tune genetic activities without altering the underlying DNA sequence. So far, four types of epigenetic modulation have been extensively studied: DNA methylation, histone …

    purdue-thes Repository record

  6. THE INTERGENERATIONAL IMPACT OF ENVIRONMENTAL EXPOSURES: MOLECULAR INSIGHTS FROM MODELLING PLURIPOTENCY TRANSITIONS THROUGH THE HUMAN GERMLINE

    STUCCHI, SARAHUniversità degli Studi di Milano2026

    … model capable of capturing transcriptomic and epigenetic dynamics across generations, thus making epigenetic inheritance experimentally tractable in humans. We then used this model to investigate the intergenerational impact of EDCs on human neurodevelopment. To this aim, we also leveraged …

    milano Repository record