Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"epigenetic changes"”.
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Epigenetic Changes in the Innate Response of Gingival Epithelium
In this study we showed TLR2 CpG promoter methylation in periodontitis affected human gingival tissues and in primary human gingival epithelial cells chronically stimulated with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and …
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… that many innate immune cells display lasting changes in their responses to challenges as a consequence of previous infections. It was determined that these long-term changes in immune responses were possible due to epigenetic or metabolomic imprinting. This phenomenon was also observed in …
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Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
… forces cells to lose their lineage-specific epigenetic marks and become totipotent again. This reprogramming process often results in epigenetic and transcriptional aberrations that compromise development. Development rates after SCNT can thus serve as a functional assay for genome-wide …
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Epigenetic Changes in Alzheimer’s and Huntington’sS Disease : A semi-quantitative analysis of histone changes
Histone acetylation is an epigenetic mechanism that plays a critical role in the regulation of gene transcription, DNA damage repair and DNA replication. Histone acetylation homeostasis is maintained by a balance in the activity of histone deacetylases (HDAC) and acetyltransferases. Disruption in …
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Investigating the effects of EZH2 inhibitors on targeting epigenetic changes in head and neck squamous cell carcinoma
… and Rb tumour suppressors are often seen. Since epigenetic modifications were identified from a large number of epithelial cancer cases, EZH2 inhibitors has been shown to be effectively targeting those cancers, and HPV relevance has been also taken into consideration. However, the results were …
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Epigenetic Response to Low-Dose Ionizing Radiation
… radiation (>100.0 cGy) have been shown to cause epigenetic disruption (Kaup, Grandjean et al. 2006; Tamminga, Koturbash et al. 2008; Ilnytskyy, Koturbash et al. 2009), which is necessary for the persistence of radiation-induced genomic instability (Rugo, Mutamba et al. 2011); however, it is …
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Age-related genetic and epigenetic chromosomal changes: A twin study
… this study were to examine acquired genetic and epigenetic changes that occur in individuals with increasing age and to determine how these changes are influenced by genetic/environmental factors. Acquired genetic changes were assessed by determining the frequency and chromosomal contents of …
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Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
… relationship between dietary patterns and epigenetic modifications such as DNA-methylation or miRNA expression can exert positive impact on preventing and managing metabolic disorders, including NAFLD within the 2030 SDG. This review aims to evaluate the influence of dietary patterns on …
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MOLECULAR MECHANISMS OF APPETITE AND ENERGY BALANCE
… of appetitive behaviours. Environmental or epigenetic changes on synapse-specific activity may predispose individuals to obesogenic behaviours. We sought to address this by deleting active zone protein, ELKS1 and ELKS2, through Nkx2.1-cre-loxP recombination. Nkx2.1 is a developmental …
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Engineered hydrogels for tracking cell signaling from the outside-in
… of these reprogramming factors leads to epigenetic changes which are not yet fully understood but are of great concern in clinical usages as epigenetic markers are heritable. The propagation of mechanochemical signals from the extracellular matrix (ECM) to the cell nucleus has emerged as …
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Metabolic and genetic factors guiding hematopoietic cell fate
… initiate differentiation-related cell state changes specifically by impairing DNA replication, rather than as a general consequence of impaired proliferation or reduced viability. Genetic screens in three cell types reveal that while different cellular contexts have divergent responses to …
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Regulation of Reparative Macrophage Transition by the B-cell Adapter for PI3K (BCAP)
… to reparative macrophages by imprinting epigenetic changes.
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The molecular mechanisms of pseudogene-mediated PTEN expression.
… at the PTEN promoter to cause a complex set of epigenetic changes. Here we show that an additional, previously uncharacterised transcript exists at the PTEN promoter. We also show that nucleolin has the ability to bind the PTENpg1 asRNA which produces a downstream effect on PTEN gene expression. …
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Loss of Mismatch Repair in the Aging Human Hematopoietic Stem Cell
All organisms undergo complex changes over time. These changes, associated with an increasing incidence of disease and decreased functional capacity, are collectively referred to as aging. To understand this process, to prolong functional capacity, and to prevent the expensive and debilitating …
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Transdifferentiation of fibroblasts to neural stem cells
… is carefully controlled by transcriptional and epigenetic changes that occur as a zygote transforms into an adult organism. This process can be reversed by the overexpression of transcription factors Oct4, Sox2, Klf4, and c-Myc, which reprogram a differentiated cell!s nucleus to one that is …
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Characterisation of Streptococcus pneumoniae opacity phase variation
… of this sequencing technology. The role of epigenetic changes mediated by genetic rearrangements in a Type I restriction-modification (RM) system on opacity phenotype was also investigated. These rearrangements result in switching between six alternative DNA methylation site specificities …
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Computational epigenomics : gene regulation, comparative methodologies, and epigenetic patterns
… This highlights the importance of studying epigenetic changes, which are dynamic chemical changes to and around the DNA. While the DNA of every cell in an individual is the same, the epigenetic context for that DNA varies from cell to cell. In this way, these epigenetic differences play a …
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The potential of epigenetic methods to provide evidence of torture
… in the genetic material (the DNA), called epigenetic marks, have been developed in recent years. These marks can change in response to environmental factors, but these changes do not alter the genetic information contained in the DNA. Changes in epigenetic marks have been correlated with …
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