Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1022 for “"epigenetic"”.
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Epigenetic Heritability in Somatic Cells
… lifespan, cells accumulate somatic mutations, epigenetic alterations, tran- scriptional noise, mitochondrial damage and irreversible protein aggregation, the so-callled hallmarks of ageing. These molecular changes tend to worsen and compound over time, yet the mechanism through which these …
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DNA methylation: the "stable" epigenetic mark
DNA methylation is regarded as a stable epigenetic mark given its faithful maintenance across successive cell divisions. Methylation occurs at most CpG sites in mammalian genomes and is generally associated with transcriptional repression. An accepted evolutionary role for DNA methylation is to …
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Epigenetic Determinants of CRISPR-Cas9 genotoxicity
… area of these concerns involves the role of epigenetic features in influencing Cas9-mediated toxicity. Epigenetics is the study of inheritable changes in gene expression that occur without altering the underlying DNA sequence. Cas9 interacts directly with the genome to introduce double strand …
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Epigenetic Memory of Mouse Intestinal Inflammation
… suggesting the possibility of memory. Such epigenetic memory may confer some adaptive resiliency to subsequent damage.
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Microfluidics for Genetic and Epigenetic Analysis
Microfluidics has revolutionized how molecular biology studies are conducted. It permits profiling of genomic and epigenomic features for a wide range of applications. Microfluidics has been proven to be highly complementary to NGS technology with its unique capabilities for handling small volumes …
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Epigenetic Mechanisms in Blast-Induced Neurotrauma
… The overall hypothesis of this work is that epigenetic regulatory mechanisms contribute to the progression of the BINT pathology and neurological impairments. Epigenetic mechanisms, including DNA methylation and histone acetylation, are important processes by which cells coordinate …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… identified, including signaling molecules and epigenetic modifiers. Specifically, mutations that affect the activity of SWI/SNF chromatin remodeling complex have been commonly reported. Mutational studies clearly indicated a role for epigenetic modifications in HCC development. However, it is …
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Does Epigenetic Silencing Affect Skeletal Muscle Angiogenesis?
… blood flow to the working skeletal muscles. Epigenetic modifications support changes in gene expression to allow for skeletal muscle adaptations. How histone silencing marks regulate skeletal muscle adaptations through angiogenesis in response to training is yet to be explored in depth. My …
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Epigenetic Patterns: Process-Driven Or Sequence-Driven?
… is striving to fill the gaps in knowledge about epigenetic regulation of biological processes - here by using the well-suited model virus, Simian Virus 40. It has for some time now been agreed upon that epigenetic modifications of histone proteins not only exists, but play a crucial role in …
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Genetic and Epigenetic Characterisation of Breast Tumours
… tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. The heterogeneity of breast tumours is reflected in the identification of at least five molecular subtypes named basal-like, luminal A, …
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Epigenetic Response to Low-Dose Ionizing Radiation
… radiation (>100.0 cGy) have been shown to cause epigenetic disruption (Kaup, Grandjean et al. 2006; Tamminga, Koturbash et al. 2008; Ilnytskyy, Koturbash et al. 2009), which is necessary for the persistence of radiation-induced genomic instability (Rugo, Mutamba et al. 2011); however, it is …
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On the epigenetic ageing clock in humans
Epigenetic clocks are mathematical models that predict the biological age of an organism using DNA methylation data, and which have emerged in the last few years as the most accurate biomarkers of the ageing process. However, little is known about the molecular mechanisms that control the rate of …
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Transcriptional and epigenetic fluctuations in single cells
… The focus of this work is to understand the epigenetic orgin of this heterogeneity. For biochemical noise arising from the intrinsic stochasticity of molecular interactions, we have experimentally established a microRNA mediated mechanism through which epigenetically determined rate …
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Epigenetic Responses of Arabidopsis to Abiotic Stress
… data on gene expression and regulation via epigenetic modification (methylation) and small RNA (sRNA). For all of the treatments except shade, the stress was limited in duration, and the plants were allowed to recover until flowering, to identify changes that persist to reproduction. At …
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Molecular and epigenetic mechanisms of fear memory
Numerous memory studies have demonstrated that epigenetic-mediated transcriptional regulation, such as post-translational histone modifications, is essential to memory formation and maintenance. Moreover, many studies on the mechanisms of memory have focused on fear memories underlying traumatic …
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Epigenetic silencing of gene expression in paediatric astrocytoma
… by genetic abnormalities, but also caused by epigenetic changes. DNA methylation is a key epigenetic mechanism that controls the regulation of gene expression. Interestingly, unlike DNA mutations, epigenetic abnormalities are reversible. The reversibility of epigenetic abnormalities upon …
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Epigenetic Modulation of Synaptic Resilience in Alzheimer’s Disease
Some individuals, here referred to as Non-Demented with Alzheimer’s Neuropathology (NDAN), retain their cognitive function despite the presence of amyloid plaques and tau tangles typical of symptomatic Alzheimer’s Disease (AD). In NDAN, unlike AD, toxic amyloid beta (Aβ) oligomers do not localize …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… genes which may be particularly susceptible to epigenetic influence. Mouse xenograft models of BRAFV600E mCRC were treated with vemurafenib or azacitidine, alone or in combination, to assess for changes in tumor size. Tumors and cell lines exposed to azacitidine were analyzed for methylation …
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Epigenetic Regulation of Nuclear Hormone Receptor DAX-1
… that expression of DAX-1 may be governed by epigenetic mechanisms. </p> <p>We sought to determine whether promoter region CpG island methylation and expression of DAX-1 were inversely related , and if the loss of DAX-1 expression in the breast cancer cell line MCF-7 is due to epigenetic …
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The Skin Remembers: Epigenetic Memories of Inflammation Past
… an adaptive mechanism whereby EpSCs retain an epigenetic memory of prior inflammatory exposure that endows them with enhanced sensitivity and responsiveness to subsequent tissue damage. During secondary injury, inflammatory memory is mediated by cytosolic dsDNA sensor and activator of the …
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