Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 201 for “"epidermal growth factor receptor"”.
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Characterizing and engineering antibodies against the epidermal growth factor receptor
Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to receptor overexpression, mutation, or autocrine ligand has been observed in a wide …
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Design and applications of antibody mimics against epidermal growth factor receptor
<p>Antibodies have been widely used as reagents, homing devices, diagnostics and as therapeutic agents against different targets in clinic and research. Recently a number of monoclonal antibodies and their drug conjugates have been approved as therapeutic agents. While these molecules have great …
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The Symptom Experience of Patients Receiving Epidermal Growth Factor Receptor Inhibitors
… the symptom experience of patients receiving epidermal growth factor receptor inhibitors (EGFRIs) for breast, colon, head and neck, and colon cancer. EGFRIs are targeted therapies used at various points along the treatment continuum for these solid tumors, and may be first, second or …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… by overexpression and/or mutation of the epidermal growth factor receptor (EGFR). Also common to this subtype of GBM is the loss of crucial tumor suppressor genes Ink4A/ARF and PTEN, which contribute to the invasive nature and unregulated proliferation that underlie the GBM pathology. The …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
The ErbB family of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… of Spitz, the main activating ligand of the Epidermal growth factor receptor (Egfr). The experiments presented show that modulation of Egfr activity causes defects in ommatidial rotation and implicate the Raf/MAPK/Pointed cascade as well as the Ras binding protein Canoe as downstream …
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Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies
… extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) has long been an attractive target for monoclonal antibodies. Intense research has culminated in the approval of two antibody-based drugs against EGFR for cancer treatment, with numerous others in …
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Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics
The epidermal growth factor receptor (EGFR, also known as ErbB 1) is a prototypical receptor tyrosine kinase (RTK) that activates multi-kinase phosphorylation cascades to regulate diverse cellular processes, including proliferation, migration and differentiation. ErbB 1 heterooligomerizes with …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… back to the plasma membrane. In the case of receptor tyrosine kinases (RTKs), such as epidermal growth factor (EGF) receptor, this important sorting step determines whether a protein returns to the surface to participate in signaling, or whether its signaling properties are inactivated …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
The epidermal growth factor receptor (EGFR) plays a pivotal role in physiological cellular processes, but its aberrant activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin …
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Contribution of Ectodomain Mutations In Epidermal Growth Factor Receptor to Signaling In Glioblastoma Multiforme
… OF ECTODOMAIN MUTATIONS IN EPIDERMAL GROWTH FACTOR RECEPTOR TO SIGNALING IN GLIOBLASTOMA MULTIFORME</strong></p> <p><strong>Publication No._________</strong></p> <p><strong>Marta Rojas, M.S. </strong></p> <p><strong>Supervisory Professor: Oliver Bögler, Ph.D.</strong></p> …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… proliferation. I also studied how the hetero receptor regulates epithelial proliferation. Results revealed that E-cadherin mutants that uncouple EGFR displayed less effective inhibition of EGFR at confluency when treated with EGF. Notably, WT E-cadherin expressing cells displayed …
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Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme
… understood. Since activating mutations in the epidermal growth factor receptor (EGFR) are commonly occurring in GBM, we examined whether EGFR could induce Fyn expression. Here, we found that wild-type EGFR, and to a greater extent hyper-activating EGFR mutants, EGFRΔIII and R108K, induce a …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… best-characterized proteins in biology is the Epidermal Growth Factor Receptor (EGFR), which has long been associated with diseases including cancer. Despite development of several EGFR inhibitors, the clinical efficacy of targeting this receptor has been minimal. This shortcoming is …
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Experimental and modeling studies of endosomal sorting using the epidermal growth factor/receptor system in fibroblasts
Receptor mediated endocytosis is the process by which cells internalize ligands which have specifically interacted with cell surface receptors. Cells have the ability to sort internalized ligands and their receptors to lysosomes for degradation, to recycle them back to the plasma membrane, or to …
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Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
… implicating spen as a positive regulator of the receptor tyrosine kinase (RTK) signaling pathway. Molecular characterization of spen has revealed that spen encodes a protein with 5476 amino acids. It contains three tandem repeats of an RNA Recognition Motif (RRM) at its N-terminus, suggesting …
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Epidermal growth factor receptor-mediated gene delivery : a model system for engineering selective gene therapy approaches
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Epidermal growth factor receptor in equine gastric stratified squamous mucosa: effect of progressive ulceration on receptor density
… here was to document the distribution of epidermal growth factor receptor (EGFr) and quantitate receptor density in normal as well as ulcerated equine gastric squamous mucosa. Fifteen horses with endoscopically normal stomachs were divided into three equal groups. Group 1 was a normal …
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