Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"epidermal differentiation"”.
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Transcriptional functions of the corepressor Sin3A in skin
Upon activation in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of adhesion molecules and essential cytoskeleton components. It has also …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… the mechanisms behind oncogene tolerance during epidermal development, a time of significant physiological tissue expansion, has not been explored. This is exemplified in RASopathies, where patients rarely develop epidermal defects or cancers despite germline mutations in the RAS/MAPK signaling …
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The role of the SWI/SNF ATP dependent chromatin remodelling complex in the regulation of the human hair follicle cell proliferation and control of the human cutaneous wound healing
… variable subunits. BRG1 is required for terminal epidermal differentiation in mice and humans and for hair follicle stem cell activation during mouse hair follicle regeneration and cutaneous wound healing. However, the role of SWI/SNF complexes in human hair growth and wound healing remain …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… for pre-cancerous lesions. Homeostasis and differentiation of the skin is regulated through calcium-associated signaling. Better understanding the role of calcium regulation in the epidermis and its relation to the progression of skin cancer could be important in finding new interventions. …
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Epigenetic Regulation of Skin Development and Postnatal Homeostasis The role of chromatin architectural protein Ctcf in the control of Keratinocyte Differentiation and Epidermal Barrier Formation
… roles in the control of lineage-specific differentiation during development. However, mechanisms that regulate higher-order chromatin remodelling and transcription of keratinocyte-specific genes that are clustered in the genome into three distinct loci (Keratin type I/II loci and Epidermal …
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Identification and characterization of the gene responsible for the <em>matted</em> mouse phenotype
… assaults and maintaining homeostasis. The differentiation of keratinocytes into toughened corneocytes begins in the basal layer of the epidermis and culminates in the formation of the stratum corneum (SC). Corneocytes are terminally differentiated cells which form a protective shield …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… study investigated the role of PRC2 in human epidermal homeostasis and hair growth. The expression of EZH2 was elevated in differentiating suprabasal layers of the human epidermis. Consistently, EZH1/2 expression and enzymatic activity was upregulated in differentiating primary human …
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Skin barrier dysfunction in common genetic disorders
… gene (FLG) that lies within a cluster of epidermal genes known as the epidermal differentiation complex (EDC) on chromosome 1q21. Recent studies in Europe have shown that null mutations in FLG lead to the loss of the filaggrin protein; this is the underlying genetic cause of ichthyosis …
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Role of Stat3 In Keratinocyte Stem Cells During Skin Tumorigenesis
… functions, including development, proliferation, differentiation, migration and in cancer development. In the present study, we examined the impact of Stat3 deletion or activation on behavior of keratinocytes, including keratinocyte stem cells (KSCs). Deletion of Stat3 specifically in the bulge …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… loss), transformation of hair follicles to epidermal cysts and neonatal lethality, the latter seen in the absence of all Notch signaling. Although these phenotypes were previously described, the exact mechanisms underlying them have not been fully understood. This dissertation focuses on …
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RBPjk-Independent, NICD-Dependent Signals in Rbpj-/- Hair Follicle Keratinocytes Cause a Milder Phenotype in RBPjcKO Animals
… acting either in stem cell maintenance or differentiation. In the skin, Notch is essential for epidermal differentiation, maintenance of hair follicle morphology and terminal differentiation of the inner and outer root sheath cells. Ligand-dependent activation, gamma-secretase-dependent …
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Role of Krox20 Transcription Factor and Krox20+ Stem Cells in Epithelial Tissue Development and Homeostasis
… maintain their identity, and differentiate. Epidermal SCs occupy exclusive niches, priming them for giving rise to specific portions of the of the interfollicular epidermis (IFE) and hair follicle (HF). During homeostasis, the bulge SCs generate the lower portion of the HF, while isthmus, …
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Preparation And Characterization Of Acitretin-Loaded Niosomes For Psoriasis Treatment
… chronic skin disease that manifests as impaired epidermal differentiation. The disease is typically treated with acitretin, an effective oral cytotoxic agent. However, due to its side effects, its use is highly limited. Topical delivery of acitretin may decrease the systemic toxicity and increase …
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The role of photoreceptors in human skin physiology; potential targets for light-based wound healing treatments. Identification of opsins and cryptochromes and the effect of photobiomodulation on human skin and in cultured primary epidermal keratinocytes and dermal fibroblasts
… of these photoreceptors was retained in primary epidermal keratinocytes and dermal fibroblasts in culture; both cell types expressed OPN1-SW, OPN3, CRY1 and CRY2, at the mRNA and protein level. OPN2 was only expressed in cultured dermal fibroblasts, while in line with in situ expression, OPN5 was …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
… as cell growth and proliferation, metabolism, differentiation and apoptosis. In addition, functional redundancy with MYCL and MYCN proteins as well as dose dependency, complicates the identification of the most relevant biological functions. Studies in tissues with high proliferative capacity …
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Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… including epithelial stem cell proliferation, differentiation, and adherence programs. To determine the roles of these isoforms in skin development and maintenance, isoform specific p63 conditional knock out mice were generated by our lab. TAp63-/- mice age prematurely, develop blisters, and …
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Investigating Differentiation: A Role for Organelle Inheritance in Epidermal Growth
<p>Balanced growth and differentiation is essential to tissue morphogenesis and homeostasis. How imbalances arise in disease states such as cancers is poorly understood. Loss of differentiation is associated with poorer prognosis in human patients and increasing malignancy in animal models. Here we …
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… complex to the cell cortex of cultured epidermal cells. In addition, I found that interaction with LGN is necessary but not sufficient for cortical NuMA recruitment. This led me to examine the role of additional NuMA-interacting proteins in spindle orientation. Notably, I identified a …