Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"epidermal development"”.
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The Role of Spindle Orientation in Epidermal Development and Homeostasis
… cellular diversity within a tissue. During the development of the multilayered mammalian epidermis, mitotic spindle orientation in the proliferative basal cells is crucial not only for dictating daughter cell fate but also for initiating stratification of the entire tissue. A conserved protein …
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Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… structural similarities, p63 is critical for the development and maintenance of stratified epithelial tissues, unlike p53. p63 is highly expressed in the epidermis and previously has been shown to play a critical role in the development and maintenance of the epidermis. The study of p63 has been …
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Investigations on the influence of CO2 on leaf epidermal development in Arabidopsis thaliana
… plant's exchange of gas, water and nutrients. Epidermal development is environmentally sensitive, allowing plants to adapt successive phytomers to serial stresses and opportunities throughout the growth cycle. During leaf development, cell patterning, cytological features and epicuticular wax …
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Investigating Differentiation: A Role for Organelle Inheritance in Epidermal Growth
… growth and differentiation in the context of epidermal development, where populations of stem cells are maintained in careful equilibrium and induced to proliferate and differentiate in response to stimuli such as injury or cyclical growth signals. During development, a naïve epidermis …
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Translational mechanisms of stem cell fate regulation in epidermal oncogene tolerance
… the mechanisms behind oncogene tolerance during epidermal development, a time of significant physiological tissue expansion, has not been explored. This is exemplified in RASopathies, where patients rarely develop epidermal defects or cancers despite germline mutations in the RAS/MAPK signaling …
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Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
During tissues development multipotent progenitor cells establish tissue-specific gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… and plays essential roles in regulating epidermal development and homeostasis. Utilizing a <em>ΔNp6</em>3-conditional knockout mouse model generated in the Flores lab, I demonstrated that the loss of ∆Np63 in basal epidermal cells elicits an “irreversible” epithelial to mesenchymal …
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Molecular Regulation of Hair Follicle Morphogenesis
… of epithelial cells. As hair follicle development proceeds, stem cells are specified and set aside to fuel the postnatal hair cycle and repair the epidermis after injury. Although many signaling pathways have been identified by genetic studies to be essential for the induction of hair …
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Merlin Mediated Regulation of Hair Follicle Morphogenesis
<p>Epidermal homeostasis is paramount for the ongoing function of the skin as the primary barrier between a mammalian organism and the external environment. Homeostasis is achieved through a complex and delicate balance of cell death, cell proliferation and cell differentiation. Critical for …