Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"epicardium"”.
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The Epicardium as the Conductor of Cardiovascular Cells in Cardiac Regeneration
… is paracrine-mediated effects of the epicardium towards CMs and endothelial cells (EC). While RNA sequencing data has been used to identify putative players in hESC-EPIs, little is known about their involvement in mediating hESC-CM maturation and angiogenesis. Here, the role of …
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BNC1 Regulates Human Epicardial Heterogeneity and Function
The epicardium is a transcriptionally heterogeneous cell layer covering the heart, crucial to correct cardiovascular development. Following epithelial-to-mesenchymal transition (EMT), epicardial cells migrate into myocardium, form coronary smooth muscle cells and cardiac fibroblasts, and instruct …
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The Derivation of the Myocardial, Epicardial and Endocardial Lineages from Human Pluripotent Stem Cells
… from three major lineages: the myocardium, the epicardium and the endocardium. The myocardium is the working muscle and comprises primarily the ventricles and atria. The epicardium represents the outer epithelial layer that surrounds the myocardium and plays a pivotal role during cardiovascular …
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Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
… were improved by co-delivering hESC-derived epicardium. Clinically, the main challenge remains chronic heart failure. However, hESC-cardiomyocytes alone, in the chronically infarcted heart, have shown no benefit. Here, we show that both species-matched cellular therapy and combination therapy …
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Defining the Developmental Signals of the Cardiac Fibroblast
… transition (EMT) of epicardial cells. The epicardium (outer surface of the heart) functions as a pool of progenitor cells for the coronary vasculature and interstitial connective tissue during embryonic development. Although several signaling pathways have been identified that disrupt EMT, …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
… that EpC can be modified in the ventricular epicardium using ionic and osmotic challenges to the Langendorff-perfused heart. In the first series of experiments, we show that reducing EpC via treatment with mannitol or hyponatremia can unmask conduction deficits that are otherwise below the …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… of cardiovascular disease. Derived from the epicardium, coronary vessel formation relies on growth factor as well as extracellular matrix (ECM) influences on cells of the epicardium that regulate proliferation, motility, invasion and differentiation. The Transforming Growth Factor β (TGFβ) …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… EPDCs caused by a failure in cell exit from the epicardium. This defect resulted from decreased expression of genes involved in the EMT process and continued epithelial gene expression. Finally, I showed that Sox9, an SRY-related transcription factor, is a critical downstream mediator of PDGF …
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MRI of structured-based ventricular mechanics
… variation from a left-handed helix at the epicardium to a right-handed helix at the endocardium. It also shows a septum-versus-free-wall polarization of sheet orientations, a pattern recently documented in canine hearts. Analysis of conjoint data of diffusion and strain gives a clear …
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Myocardial Topical Negative Pressure
… no zone of hypoperfusion was observed in the epicardium. And finally it was concluded that there where no significant difference between microvascular blood flow during 20 minutes of continuous and intermittent TNP at -50 mmHg. In conclusion, myocardial applied topical negative pressure may in …
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Development and Analysis of a Minimally Invasive Post-Infarction Epicardial Patch Delivery Device
… positioning and adhering the patches to the epicardium. Such a tool would be helpful in applying therapeutics like the patch, presenting a low-cost, accessible solution for interventionalists. This delivery tool is still in development, as it is on its fourth iteration and in the future, …
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
… This strategy enabled us to identify the epicardium and the subepicardium of the heart as the cardiac hypoxic stem cell niche, which houses a metabolically distinct, Hif-1α positive population of glycolytic cardiac progenitors. Moreover, our studies indicate that Meis1, which regulates HSC …
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Investigating microRNAs during cardiac development in the chick
… of inhibition of canonical Wnt signalling in the epicardium.
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Identification and characterisation of a novel, multi-potent, skeletal muscle-derived stem cell with broad developmental plasticity
… mice with the majority of cells found within the epicardium. There was rapid decline in abundance during postnatal development. CD45-/Sca-1+ CSCs were isolated from 6 week old mice via MACS technology and assessed for PW1 expression (83%). In summary, this study showed PICs have broad …
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Novel Phenotyping of the Myocardium by Diffusion Tensor Cardiovascular Magnetic Resonance
… cardiomyocyte arrangement (left-handed in the epicardium through to right-handed in the endocardium) drives torsion. Sheetlets are aggregated cardiomyocytes that realign from wall-parallel in diastole, to wall-perpendicular in systole. This sheetlet mobility is integral to wall thickening. …
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Cardiac repair post-myocardial infarction: Roles of the primary cilium and the long non-coding RNA Malat1
… EMT post-MI, which enhances the contribution of epicardium-derived cells (EPDCs) to neovascularization. This reduced deleterious cardiac remodeling and preserved cardiac function. Contrastingly, Malat1 deficiency augmented cardiac cell death from MI. Unexpectedly, rather than affecting apoptosis, …
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Noninvasive Multi-Modality Studies of Cardiac Electrophysiology, Mechanics, and Anatomical Substrate in Healthy Adults, Arrhythmogenic Cardiomyopathy, and Heart Failure
… geometry, ECGI reconstructs voltages on the epicardium. This thesis applies ECGI to novel studies of human heart function and disease and explores new combinations of ECGI with additional imaging modalities.</p><p>ECGI was applied in combination with late gadolinium enhancement (LGE) scar …
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Epicardial Wireless Pacemaker for Improved Left Ventricular Resynchronization (Conceptual Design)
… is a leadless device mounted directly on the epicardium of the left ventricle. The epicardial pacemaker can be implanted using a thoracoscopic procedure during implant of the master unit. In special events, it can be implanted using prophylactic techniques during heart bypass surgery of other …
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Coronary flow mechanics: an anatomically based mathematical model of coronary blood flow coupled to cardiac contraction
… the endocardium and atmospheric pressure at the epicardium. IMP and vessel stretch are included in the transmural pressure radius relationship to model the effect of myocardial deformation on coronary flow. The calculated coronary blood flow through the contraction cycle shows that arterial flow …
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