Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"ephrins"”.
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… hormone (LH) that triggers ovulation. Ephrins (Efn genes) and Eph receptors (Eph genes) are membrane-associated signaling molecules that mediate communication at sites of cell-cell contact, and have been extensively studied in the context of embryonic development. The published …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… Preliminary data has shown that EphRs and ephrins are expressed during in vitro differentiation. In addition, we see EphA7 localization at the face of neural rosettes, where it co-expresses with markers of neuroblast identity. However, the role of Eph receptors and ephrins in neurogenesis …
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Activated EphA4 receptor in <i>Xenopus laevis</i> acts rhrough src- like tyrosine kinase p59fyn to inhibit RhoA GTPase
<p>Eph receptors and their ligands, ephrins, have been implicated in many important developmental processes and in tumorigenesis. The activation of EphA4 receptors in the frog, <em>Xenopus laevis</em>, causes loss of cell adhesion, tight junctions, and stress fibers. Previous studies revealed that …
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
Eph receptors and their membrane-bound ligands, ephrins, provide key signals in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding retinal ganglion cell (RGC) axons from the retina to the right targets in …
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Einfluss frühembryonaler Manipulation der Augenanlage auf das Verhalten und auf Positionsmarker im optischen Tektum des Haushuhns
… of the eye anlage there was graded expression of ephrins between E11 and E15. The intensity of expression was influenced by the manipulation of the eye anlage. The results let us to the conclusion that on the molecular level the distribution patterns are mainly determined genetically and there …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
… receptors that are activated by 9 different ephrins throughout the animal kingdom. Eph receptors and their ligands are both anchored to the plasma membrane, and are subdivided into two subclasses (A and B) based on their sequence conservation and binding preferences. The critical roles of …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… and physiology. Moreover, since the ephrins (ligands) are expressed in the pancreatic mesoderm and blood vessels and the Eph (receptors) are expressed in the pancreatic endoderm; our results suggest that Eph/ephrinB-mediated tissue-cross-talk is required for proper pancreatic …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… signals include semaphorins, slits, netrins and ephrins/Eph, whereas mechanical signals include tissue stiffness, viscosity and cellular forces. In the developing embryo, chemical and mechanical signals are not isolated. However, how cells integrate these two different types of signals remains …
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The Cloning and Characterization of MADD-4, A Novel Guidance Cue in C. elegans
… guidance cues such as the slits, ephrins and semaphorins were found to be the primary cue for muscle arm extension. This suggested that muscle arms were likely responding to a novel guidance cue. In this thesis, I describe the cloning and characterization of MADD-4, a novel …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
Eph receptors are transmembrane RTKs that are activated by clustering that occurs on binding to membrane-tethered ephrin ligands. Two members or the ephrin family, ligand ephrinB2 and receptor EphB4 are known for their ability to distinguish arterial versus venous endothelium upon their expression …
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Mechanisms of Eph/ephrin mediated cell-cell communication
… by the previous findings that activated ephrins cluster in cells, we hypothesized that these Eph/ephrin clusters undergo endocytosis. We developed immunofluorescence internalization and co-culture assays to study clustering and endocytosis at cell-cell contact sites. We established an …
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EPH-B and Ephrin-B Signaling in Migration and Proliferation of Stem Cells
In this dissertation, I investigate the role of Eph-ephrin signaling in the Dentate Gyrus (DG). The DG is a distinctive neuronal structure located in the hippocampus and is one of two areas in the mature brain where stem and progenitor cells reside to continuously produce new neurons throughout …
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Novel Non-Repulsive Outcomes From Ephrin-B Reverse Signaling
… roles for reverse signaling through B-subclass ephrins during embryonic development. The stereotypical outcome of Eph-ephrin signaling has long been established as one of cell-cell repulsion, elicited through a localized breakdown of the actin cytoskeleton. In contrast to this dogma, I have …
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The Molecular Regulation of Spinal Nerve Outgrowth
… Interestingly, similar repellent cues (e.g. Eph/Ephrins) are expressed in the adult central nervous system (CNS) and have been shown to control connectivity and plasticity throughout life. Following brain or spinal cord injury, these repellent molecules are upregulated by reactive astrocytes …
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Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… axon guidance cue responses (such as netrins and ephrins), and more generally of a wide variety of crucial biochemical signalling cascades. Variations in local tissue mechanics occur naturally during development and disease states, and could therefore be important in determining cellular responses …