Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"ephrin"”.
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Ephrin Receptors, AIY Interneuron Physiology, and Behavior
… and ventral AIYL/R contact. Conversely, the ephrin EFN-4 is required for dorsal AIYL/R connectivity. We have extended these studies and show that the AIYL/R ventral contact is mediated via the ephrin gene <em>efn-1</em>. In addition, we show that this connectivity requires both VAB-1 kinase …
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EphB: Ephrin-B Bidirectional Signaling in Retinocollicular Mapping
… Expression of EphB receptor tyrosine kinases and ephrin-B ligands in the visual system signify the potential role for EphB:ephrin-B bidirectional signaling in the development of the visual system. Previous studies of EphB2-/-;EphB3-/- (receptor null mutant) and EphB2lacZ/lacZ;EphB3-/- (EphB2 …
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Mechanisms of Eph/ephrin mediated cell-cell communication
Eph receptors and their membrane associated ephrin ligands mediate cell-cell repulsion to guide migrating cells and axons. A peculiarity of this signaling system is that both receptors and ligands can transduce signals into the cell resulting in a bidirectional signaling mode. An important step of …
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Novel Non-Repulsive Outcomes From Ephrin-B Reverse Signaling
… roles for reverse signaling through B-subclass ephrins during embryonic development. The stereotypical outcome of Eph-ephrin signaling has long been established as one of cell-cell repulsion, elicited through a localized breakdown of the actin cytoskeleton. In contrast to this dogma, I have …
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Investigations of ephrin ligands during development / by Paul Tosch.
Aims to isolate ephrin ligands from Drosophila melanogaster and analyse their involvement in Drosophila deveopment. Also investigates the potential of ephrin B-1 as a causative gene in the human condition Aicardi's syndrome.
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The mechanical regulation of Eph/ephrin signalling in the developing Xenopus brain
Eph receptors and their membrane-bound ligands, ephrins, provide key signals in many developmental processes including axon guidance. In the nervous system, concentration gradients of Ephs and ephrins are crucial in guiding retinal ganglion cell (RGC) axons from the retina to the right targets in …
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EPH-B and Ephrin-B Signaling in Migration and Proliferation of Stem Cells
… this dissertation, I investigate the role of Eph-ephrin signaling in the Dentate Gyrus (DG). The DG is a distinctive neuronal structure located in the hippocampus and is one of two areas in the mature brain where stem and progenitor cells reside to continuously produce new neurons throughout …
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
<p>Eph receptor tyrosine kinases and their ephrin ligands are required for multiple aspects of nervous system development including axon outgrowth, synaptic plasticity, and the formation of topographic maps in the visual system. The <em>Caenorhabditis elegans </em>ephrin-A, <em>efn-4</em>, has a …
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The role of EphrinA for the retinotopic map formation in mouse visual cortex
… in axonal guidance and map formation are the ephrin ligands and their Eph receptors. These molecules have been shown to contribute to topographic mapping in several mammalian brain systems including the retinotectal and retinogeniculate projection. Much less is known about mechanisms that are …
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The Intracellular Domain of EPHB1 Is Required for Axon Pathfinding at the Optic Chiasm and Corpus Callosum
… axonal pathfinding through interactions with ephrin-B proteins following axon-cell contact. Since EphB:ephrin-B binding leads to bidirectional signals, the contributions of signaling into the Eph-expressing cell (forward signaling) or the ephrin-expressing cell (reverse signaling) cannot be …
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Neural Development to Neurodegeneration Through the Mind of a Worm
… the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. elegans</em>, allow us to study the impact of EphR/ephrin genes on neuronal morphology, synapse connections, and basic behavior. In specific EphR/ephrin …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
… hormone (LH) that triggers ovulation. Ephrins (Efn genes) and Eph receptors (Eph genes) are membrane-associated signaling molecules that mediate communication at sites of cell-cell contact, and have been extensively studied in the context of embryonic development. The published …
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… Eph receptor tyrosine kinases and their ephrin ligands play a critical role during in vivo cortical development, particularly during axon guidance. Preliminary data has shown that EphRs and ephrins are expressed during in vitro differentiation. In addition, we see EphA7 localization at …
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Mapping of the binding surface between EPHA5 and antagonist peptide by NMR spectroscopy
… receptors that are activated by 9 different ephrins throughout the animal kingdom. Eph receptors and their ligands are both anchored to the plasma membrane, and are subdivided into two subclasses (A and B) based on their sequence conservation and binding preferences. The critical roles of …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
… that occurs on binding to membrane-tethered ephrin ligands. Two members or the ephrin family, ligand ephrinB2 and receptor EphB4 are known for their ability to distinguish arterial versus venous endothelium upon their expression on the cell surface. Both substances are playing an important …
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Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… nerve lesions have shown the involvement of EphA/ephrin-A in the guidance of regenerating retinal axons and the restoration of a topological organization of the retinotectal system. For the present project, future studies might involve cell culture of trigeminal motoneurons or trigeminal sensory …
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THE ROLE of THE CIRCADIAN CLOCK IN DISEASE and TISSUE FUNCTION
… a possible NOB-ROR downstream mechanism through Ephrin signaling and the NF-κB pathway. </p> <p>We also investigated the circadian regulation in the skeletal muscle through FBXL21-mediated TCAP degradation. <em>Psttm</em>, or FBXL21 loss of function mutant, affected TCAP oscillation and inhibited …
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Intrinsic constraints on cross-modal plasticity
… We demonstrate that retinal axons use an ephrin gradient present in the MGN to acquire orderly connections, akin to retinal patterning in visual targets. Using fear conditioning, we show that learning of a visual cue changes when visual input is routed through the auditory pathway. To …
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