Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ephaptic coupling"”.
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The Relationship between Ephaptic Coupling and Excitability in Ventricular Myocardium
… excitability). Computation models incorporating ephaptic coupling and sodium channel localization to cleft widths between cardiomyocytes demonstrate these findings. Conclusion: Models and experiments reveal that the excitability and perinexus relationship is biphasic where narrowing and widening …
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Modelling Artificial Stimulation and Response in Peripheral Nerves Including Ephaptic Interactions
… this study. We were interested in studying how ephaptic coupling between myelinated fibers influences activity in nerve trunks under artificial stimulation and during action potential propagation. Ephaptic interaction simulations in nerve trunks were performed to quantify this influence. For …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
… we present experimental data in support of ephaptic coupling (EpC), a theorized mechanism of conduction that resolves these apparent contradictions. In the later part of this dissertation, we address how changes in sodium concentration can alter conduction, despite conventional wisdom …
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Sex Differences in Cardiac Electrophysiology
… are passed cell to cell through two mechanisms, ephaptic coupling and gap junctional coupling. These methods of electrical communication rely on gap junctions, sodium channels and the perinexus. When conduction is disrupted it causes arrhythmias. When investigating these three critical …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
… excitability, tissue structure and electrical coupling by gap junctions (GJ), have been extensively studied. However, there are several discrepancies in cardiac electrophysiology research that have extended over decades, suggesting elements that are still not completely understood about this …
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Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling
… modifications to a secondary form of cardiac coupling known as ephaptic coupling (EpC). Therefore the work in this dissertation was twofold, 1) to examine the effects of modulating EpC through perfusate ionic concentrations while also modulating GJC and 2) to investigate the effects of …
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Extracellular Spaces and Cardiac Conduction
… thesis is to explore a structure modulating an ephaptic, or electric field, cellular coupling mechanism: the GJ-adjacent perinexus, with three specific aims. First, I identified the perinexus – a recently-established structure in rodent myocardium – in human atrial tissue. I also observed a …