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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"eosinophils"”.
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Role of eosinophils in anaphylactic reactions related to hormonal alterations
… to be made of any of the three main problems:eosinophils, enzymatic theory of anaphylaxis,or hormonal involvement in anaphylaxis. It is, however, intended to demonstrate a close interdependence and causal relation ship between disturbed enzymatic proteolysis and horonal discrasia.
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CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis allows the removal of cells without inducing an inflammatory response. Our …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of asthma, particularly through their release of mediators and cytokines. Transforming growth factor (TGF)-β also induces asthmatic features in the lungs, especially …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… tissue. In this thesis, we focused on adipose eosinophils as a key player in the immune regulation of metabolic homeostasis, by focusing on their roles in promoting adipose tissue angiogenesis and thermogenesis, which expends energy and drives weight loss. Using RNA sequencing (RNA-seq) data …
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Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
… a pro-inflammatory pathway in human blood eosinophils and airway epithelial cells involving G-proteins and decrease in intracellular free calcium.|The effect of IPD on G-proteins, activated nuclear factor kB (NF-kB), P (I) 3-kinase and Akt was evaluated using Western blotting on cellular …
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Chloride Channel 3 (CLC3), an Immune Antiporter in the Migration and Activation of Human Eosinophils in Allergic Asthma
… and heterogeneous disease of the airways. Eosinophils migrate to the airways under the influence of chemokines to start an excessive damage and repair cycle leading to airway inflammation and remodeling in allergic asthma. TGF-β has been closely related with eosinophils in airway …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
Eosinophils are associated with various inflammatory diseases in which they participate through the release of mediators. Eosinophils thereby function as effectors and immunoregulators and contribute to inflammation-associated disease symptoms. The high mobility group protein B1 (HMGB1) was …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… innate lymphoid cells, neutrophils and eosinophils. While transcript abundance for the β2-, α2A-, and α1A-AR genes tended to be greatest in leukocytes isolated from bovine whole blood, marked differences in AR gene expression were observed when leukocytes were separated into individual …
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
… mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites. In vitro, these cells and antibodies immobilize, damage/kill worms within the granuloma. This is yet to be confirmed in vivo. We focused on understanding: the mechanisms underlying …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… a prominent eosinophilic inflammation and as eosinophils are well recognised in eliciting tissue damage and subsequent re-modelling, we aimed to investigate the role of eosinophils in the pathogenesis of NP. Especially the regulation of interleukin-5 (IL-5) and the interleukin-5 receptor α …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… the presence of degranulated and fragmenting eosinophils. In animals presensitized to ovalbumin, antigen challenge evoked extensive accumulations of degranulated and fragmenting eosinophils concurrent with exfoliation and pitting of the epithelium and goblet cell expulsion. Neither pyrilamine …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
… by a significant and persistent increase in eosinophils. Using ILC2-deficient mice we found that acute pancreatitis induced inflammation and pancreatic epithelial necrosis were significantly reduced, while immune-profiling indicated that eosinophilia was impaired. This impairment in …
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The Influence of Environmental Conditions and Co-Occurring Parasites on Blood Physiology in Eastern Hellbenders (<i>Cryptobranchus alleganiensis</i>)
… an increase in the proportion of neutrophils and eosinophils in circulation as temperatures decreased while the proportions of lymphocytes and basophils had an inverse effect. Furthermore, the proportion of neutrophil precursors also increased as temperature decreased, which signifies recruitment …
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Development of a Linognathus Vituli Infestation Model; Population Dynamics and Host Physiologic Changes in Both Normal and Stressed Cattle
… through cellular infiltration of the skin by eosinophils, mast cells and lymphocytes. Infested and re-infested calves exhibited a marked IDST response. No systemic cell mediated response was detected. Infested animals mounted a humoral response to a soluble L. vituli antigen, but antibody …
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Correlation between Locally Produced Specific IgA and Eosinophil Cationic Protein in Nasal Lavage Fluids of Allergic Rhinitis Patients during Allergen Provocation Tests
"Background: Eosinophils are the major effector cells in nasal allergic inflammation. However, the mechanism of eosinophil activation mediated by a series of inflammatory mediators presenting in early and late responses of allergic rhinitis (AR) is not fully understood. Objective: The aim of this …
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Symptoms and aspects on eosinophil activity in allergic rhinitis
… side effects. Recruitment and activation of eosinophils is a key feature of allergic rhinitis. Eosinophils have different activation modes with subsequent mediator release. Before and during a natural birch pollen season we take nasal biopsies and utilize electron microscopy to assess …
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Innate Immune Cells may be Involved in Prepubertal Bovine Mammary Development
… the presence, location and changes in numbers of eosinophils, mast cells and macrophages in pre-pubertal bovine mammary tissue. Chemical stains and immunofluorescence were used to identify the cells in formalin fixed, paraffin embedded mammary tissue. The first set (ONT) included samples …
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Factors and Mechanisms Involved in Epithelial Injury and Repair of Equine Colon
… for the beneficial effects of acetylcysteine. Eosinophils were involved in several disease processes of the gastrointestinal tract in horses. They may be part of an initial inflammatory response of gastrointestinal mucosa to injury, and could have detrimental effects in several diseases …
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Comparison of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native and Susceptible Suffolk Sheep
… challenge, Suffolk lambs did not. The numbers of eosinophils within the abomasal mucosa reflect the magnitude and timing of fecal egg count reductions in both breeds. Additionally, the elevated levels of eosinophils within the abomasal mucosa of Native lambs at 3 DPI are likely to be involved with …
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TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
… airway remodeling inflammatory cells including eosinophils and neutrophils penetrate the epithelium leading destruction of the tissue. Eosinophils, primary inflammatory cells, release TGF-ßl, a potent mediator of epithelial damage. Expression of TGF-ßl is higher in asthmatics. TGF-ßl can induce …
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