Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"eosinophilic"”.
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A Comprehensive Assesment of Eosinophilic Oesophagitis
Introduction Eosinophilic oesophagitis (EoE) is an uncommon disease that has recently been experiencing an increase in incidence and prevalence. Due to the similarities, it is challenging to distinguish EoE from its primary differential diagnosis, gastro-oesophageal reflux disease (GORD). The lack …
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Aspects on the management of patients with eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. …
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Eosinophilic Asthma Response to Therapy: 129Xe Magnetic Resonance Imaging and Computed Tomography
… been developed to treat patients with severe eosinophilic asthma who experience frequent exacerbations, poor quality of life and increased risk of mortality. Whether this therapy results in disease modifying activity, specifically in the asthmatic airways and pulmonary vasculature, is still …
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The Pathophysiology of Eosinophilic Esophagitis: Altered Mechanisms of Antigen Detection in the Esophagus
… the esophagus has emerged, which is now known as eosinophilic esophagitis (EoE). Incomplete knowledge regarding the pathogenesis of EoE has limited treatment options. EoE is known to be a Th2-type immune-mediated disorder. Based on previous studies in both patients and experimental models, it is …
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Exacerbation and glucocorticoid toxicity profile in patients receiving mepolizumab for severe eosinophilic asthma
The treatment of patients with severe eosinophilic asthma has been transformed with the arrival of biological drugs targeting the type 2 cytokine pathway. One of these drugs is mepolizumab, a humanised monoclonal antibody against the eosinophil activating cytokine, interleukin (IL)-5, has …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… polyps (NP) are associated with a prominent eosinophilic inflammation and as eosinophils are well recognised in eliciting tissue damage and subsequent re-modelling, we aimed to investigate the role of eosinophils in the pathogenesis of NP. Especially the regulation of interleukin-5 (IL-5) and …
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Functional changes in the ovary and genital tract, as estimated by the appearance of ovarian eosinophilic granulated cells
Thesis (M.S.)--Michigan State University. Dept. of Physiology, 1966
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… S. aureus enterotoxins in the regulation of both eosinophilic inflammatory and eicosanoid pathways. We first show that nasal polyposis/aspirin intolerance was associated with increased concentrations of eosinophil-related mediators, as well as of IgE antibodies to S. aureus enterotoxins. …
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A Novel Mouse Model of Asthma Induced by Cockroach
… hyper-responsiveness (AHR) to methacholine, eosinophilic and neutrophilic inflammation, and airway mucus gland hyperplasia. Endotoxin added in CR attenuated eosinophilic inflammation, IL-13 in BAL fluid, and goblet cell hyperplasia of respiratory epithelium, however, did not affect AHR. …
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Το ηωσινόφιλο κοκκίωμα των οστών: από ορθοπεδική άποψη
THIRTY FIVE CASES OF EOSINOPHILIC GRANULOMA OF BONE WHICH WERE TREATED IN THE ORTHOPAEDIC CLINICS OF ASCLIPIION HOSPITAL DURING THE LAST 20 YEARS, HISTOLOGICALLY CONFIRMED, WERE REVIEWED. THE RARITY OF THE DISEASE WAS CONFIRMED BECAUSE ITS FREQUENCY WAS FOUND ONLY 1% IN RELATION TO THE OTHER …
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A Histopathological Review of Immune Response in Largemouth Bass to Parasitic Infections of Soft Tissues
… This study investigated the response of eosinophilic cells and macrophage aggregates to parasites in the livers, spleens, and gonads of Largemouth Bass, <em>Micropterus salmoides</em>. Largemouth Bass were sampled from three bodies of water in the Chattahoochee Valley of varying levels of …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
… and a lack of knowledge regarding its role in eosinophilic disorders, we hypothesized that eosinophil-derived HMGB1 may affect airway cells and thus be involved in the pathogenesis of eosinophilic disorders such as asthma and allergy. The subcellular expression pattern of HMGB1 was …
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Mold Induced Asthma: Not all Molds are Created Equal
… of IL-17A resulted in strong AHR and eosinophilic inflammation following A. versicolor exposure. In Dectin-1 deficient mice, A. versicolor exposure resulted in markedly attenuated IL-17A, robust AHR, and eosinophilic inflammation compared to wild type mice. A similar phenotype was …
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Einfluss der Anästhetika Sevofluran und Propofol auf den nekrotischen und den apoptotischen Zelltod nach inkompletter zerebraler Hemisphärenischämie und Reperfusion in der Ratte über einen Beobachtungszeitraum von 28 Tagen
… Hematoxylin-Eosin staining was used to evaluate eosinophilic cell damage and tissue damage in 7 μm sections in the hippocampus, dentate gyrus and surrounding tissues. Immunohistochemistry was used to detect activated caspase-3 as a marker of apoptotic cell death. To distinguish activated …
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Symptoms and aspects on eosinophil activity in allergic rhinitis
… or not a topical ß2-agonist (formoterol) affect eosinophilic inflammation in allergic rhinitis. We demonstrate that the ß2-agonist neither affects symptoms and eosinophilic inflammation in allergic rhinitis nor the efficacy of a topical corticosteroid. Employing the allergen challenge model, and …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… remodeling. On the cellular level, pulmonary eosinophilic infiltration and augmented levels of serum IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
… inflammation and also in human patients with eosinophilic esophagitis and asthma. Thus, miR-21 is a clinically relevant biomarker for Th2-type pathologies. Our results define a key function for Bcl6 in repressing Gata3 function and miR-21 expression in Tregs, and provide greater understanding …
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Development of screening assays to test novel integrin antagonists in allergic inflammation
… Analyzing the supernatant of TNF-a-treated (24h) eosinophilic cells (EoL-1), we report that levocabastine reduces the TNF-a-induced release of the cytokines IL-12p40, IL-8 and VEGF. Finally, in a model of allergic conjunctivitis, levocastine eye drops (0.05%) reduced the clinical aspects of the …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… conjunctival infiltrate which was pre-dominantly eosinophilic. Peak emigration occurred at six hours after treatment, at which time significant damage to the conjunctival epithelium and depletion of goblet cell numbers was correlated with the presence of degranulated and fragmenting eosinophils. …
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