Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"eosinophilia"”.
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Aspects on the management of patients with eosinophilic esophagitis
… by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. Aims: The overall aim of this thesis was to examine the clinical aspects on the …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
… have several type 2 immune features, including eosinophilia, and considering ILC2s are potent inflammatory mediators, this project addresses the role of ILC2s in epithelial damage and organ remodelling in both acute and chronic pancreatitis. We identified pancreatic ILC2s and characterised their …
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Sensory Neurons Initiate Tuft Cell-Dependent Sinonasal Allergic Inflammation via Substance P
… incited a significant expansion in tuft cells, eosinophilia, sneezing, Type 2 immune responses, and elevated release of neuropeptides. Strikingly, mice devoid of tuft cells exhibited an absence of these responses, notwithstanding the persistence of eosinophilia and elevated neuropeptide levels. …
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Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
… by airway hyperresponsiveness (AHR), airway eosinophilia, and airway remodeling. Homeostasis in the lung is partially maintained by the neuroimmune axis, where cross-talk between these systems is mediated via cytokines, neuropeptides and their receptors. The studies described herein evaluate …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… increased tissue IL-4, IL-5 and long-lasting eosinophilia. We further demonstrated that systemic influences of N. brasiliensis infection results in exacerbated genital pathology and inflammation, following subsequent intravaginal herpes simplex virus type II (HSV-2) infection. Increased HSV-2 …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… prick tests, but correlated with the degree of eosinophilia. In addition, we demonstrated the organisation of secondary lymphoid tissue in NP tissue and a polyclonal hyper-immunoglobulinemia E associated with the presence of IgE specific to S. aureus enterotoxins (SAEs), colonization with S. …
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An investigation into the use of a commonly available fabric dye as a routine stain for tissue samples to be used as a first line, low cost, diagnostic adjunct for the diagnosis of anaphylactic death at autopsy, in a resource-challenged environment
… was undertaken, with a view to determine if eosinophilia was present in tissue samples of the spleen, in accordance with previously published research. Suitable cases of non-anaphylactic death were used as controls. Use was made of two commonly available fabric dyes as alternative stains to …
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Bone Marrow Charges in Individuals With Extramedullary Malignant Neoplasms
… anemia and a marked leukemoid blood picture with eosinophilia. Diagnostic procedures and therapy were directed toward the clinical diagnosis of leukemia. A perusal of English and American literature at that time revealed only very general statements regarding bone marrow changes associated with …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
… class switching to IgE. A reduction in airway eosinophilia in the absence of regulatory T cells suggested an alternative mechanism of protection employed by MSC. Pre-incubation with MSC inhibited the expression of important adhesion markers on eosinophils which most likely affected their …
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Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
… mice had decreased lung cellular infiltration, eosinophilia and IL-13. These results demonstrate that HuR plays a pivotal role in maintaining normal IL-2 homeostasis, augmenting Th2 differentiation and promoting allergic airway inflammation.
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Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
… process by reducing serum IgE levels and eosinophilia. The exact intracellular signaling mechanisms used by IPD have not been identified and this research was designed to identify the pathways and second messengers, utilized by IPD, to facilitate its mode of action. Since IPD has been …
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Mold Induced Asthma: Not all Molds are Created Equal
… induced robust airway hyperresponsiveness (AHR), eosinophilia, and a predominately Th2 response, while A. versicolor induced a strong Th17 response and neutrophilic inflammation, but very mild AHR. Neutralization of IL-17A resulted in strong AHR and eosinophilic inflammation following A. …
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Airway inflammation, diagnosis, perception of asthma, and sputum zinc levels in a community cohort.
… is associated with these outcomes. Sputum eosinophilia was not associated with an altered POD in subjects with and without asthma. There has been mounting research establishing the role of zinc as an immunomodulator in asthma. Mouse models have demonstrated that zinc deficiency is …
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Long-term HIV and tuberculosis outcomes in co-infected patients with treatment limiting severe cutaneous adverse reactions
… with 32, 13 and 3 cases of drug reaction with eosinophilia and systemic symptoms, StevensJohnson syndrome/toxic epidermal necrolysis and generalised bullous fixed drug eruption respectively. Nine (19%), all HIV-positive, were deceased at 12-months, and 12 (25%) were lost to all care levels. …
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Examining personal memory in film: A reflection of documenting memory-stories in Reimagining Memories
… with 32, 13 and 3 cases of drug reaction with eosinophilia and systemic symptoms, StevensJohnson syndrome/toxic epidermal necrolysis and generalised bullous fixed drug eruption respectively. Nine (19%), all HIV-positive, were deceased at 12-months, and 12 (25%) were lost to all care levels. …
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Comparison of host-parasite relationships of Fasciola gigantica infection in cattle (Bos indicus) and swamp buffaloes (Bubalus bubalis)
… in the blood increased in infected animals. The eosinophilia observed may have resulted from the generalized inflammation following liver fluke infection and may not be protective as migrating flukes or dead flukes with surrounding eosinophils were not seen in the liver. Eosinophilia also …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… IL-5, IL-9 and IL-13), increased airway eosinophilia, and mucin hypersecretion. Although there are several therapeutics currently treating asthmatic patients, some of these treatments can result in drug tolerance and may be linked to increased mortality. CpG oligodeoxynucleotides (ODNs) …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… analog suppressed the development of a pulmonary eosinophilia and the recruitment of allergen-specific CD4+ T cells into the airways. To assist in resolving the mode of action of these compounds the expression of CB2 receptors on Th2 cells was examined using a novel NBD-labeled CB2-selective …
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THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
… analog suppressed the development of a pulmonary eosinophilia and the recruitment of allergen-specific CD4+ T cells into the airways. To assist in resolving the mode of action of these compounds the expression of CB2 receptors on Th2 cells was examined using a novel NBD-labeled CB2-selective …
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Inducible Epithelial Resistance Against Acute Viral Pneumonia and Chronic Asthma
… Pam2-ODN after viral clearance displayed reduced eosinophilia that was associated with reduced lung epithelial IL-33 production. Findings from this study reveal opportunities for targeted immunomodulation to protect susceptible individuals from mortality of respiratory virus infections and …
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