Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"eosinophil"”.
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Molecular genetic mechanisms of eosinophil activation in aspirin-exacerbated respiratory disease : Genetic mechanisms of eosinophil activation
Background and Objective: Eosinophilic airway inflammation is a common pattern in various phenotypes of asthma. Persistent eosinophil activation finding in both upper and lower airway mucosa is a central feature of aspirin-exacerbated respiratory disease (AERD). As interleukin (IL)-5 mediated …
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Symptoms and aspects on eosinophil activity in allergic rhinitis
… side effects. Recruitment and activation of eosinophils is a key feature of allergic rhinitis. Eosinophils have different activation modes with subsequent mediator release. Before and during a natural birch pollen season we take nasal biopsies and utilize electron microscopy to assess …
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NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity
Hypereosinophilic (HES) syndrome is an umbrella term encompassing several disease subsets that affects humans and veterinary species, ultimately resulting in >1,500 eosinophils/uL circulating in the blood documented over six-months. This eventually culminates in end-organ infiltration and increased …
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The Eosinophil Granular Leukocyte; Source and Target of High Mobility Group Protein B1
Eosinophils are associated with various inflammatory diseases in which they participate through the release of mediators. Eosinophils thereby function as effectors and immunoregulators and contribute to inflammation-associated disease symptoms. The high mobility group protein B1 (HMGB1) was …
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Adrenergic Receptor Gene Expression in Bovine Leukocytes and Effects of Adrenergic Agonists on Neutrophil and Eosinophil Function
… innate lymphoid cells, neutrophils and eosinophils. While transcript abundance for the β2-, α2A-, and α1A-AR genes tended to be greatest in leukocytes isolated from bovine whole blood, marked differences in AR gene expression were observed when leukocytes were separated into individual …
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Correlation between Locally Produced Specific IgA and Eosinophil Cationic Protein in Nasal Lavage Fluids of Allergic Rhinitis Patients during Allergen Provocation Tests
"Background: Eosinophils are the major effector cells in nasal allergic inflammation. However, the mechanism of eosinophil activation mediated by a series of inflammatory mediators presenting in early and late responses of allergic rhinitis (AR) is not fully understood. Objective: The aim of this …
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CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis allows the removal of cells without inducing an inflammatory response. Our …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… did not respond to any of the forms of the eosinophil chemotactic factor of anaphylaxis (ECF-A) or bradykinin (BK). Histamine elicited a dose-dependent conjunctival infiltrate which was pre-dominantly eosinophilic. Peak emigration occurred at six hours after treatment, at which time …
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Characterizing Host Protective Immune Responses to the Parasitic Worm Heligmosomoides polygyrus
… mostly alternatively activated macrophages and eosinophils, accumulate around the tissue encysted parasites. In vitro, these cells and antibodies immobilize, damage/kill worms within the granuloma. This is yet to be confirmed in vivo. We focused on understanding: the mechanisms underlying …
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TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
… airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of asthma, particularly through their release of mediators and cytokines. Transforming growth factor (TGF)-β also induces asthmatic features in the lungs, especially …
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Soluble C-Kit Receptor Level May Be a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation
… inflammation composing activated mast cells and eosinophils. Mast cell development and survival is dependent on the Kit-mediated activation and this stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether SCF/c-kit pathway induced inflammation is associated …
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A Study of the Relationship between Preoperative Anxiety and Postoperative Vomiting
… (systolic blood pressure, heart rate, and eosinophil count) and one psychologic measure (Anxiety Differential Scale) were selected to determine each patient's anxiety level. Sub-hypotheses that the higher the preoperative systolic blood pressure, heart rate, or Anxiety Differential score, …
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Using immune cells to combat obesity: adipose eosinophils as mediators of metabolic homeostasis
… tissue. In this thesis, we focused on adipose eosinophils as a key player in the immune regulation of metabolic homeostasis, by focusing on their roles in promoting adipose tissue angiogenesis and thermogenesis, which expends energy and drives weight loss. Using RNA sequencing (RNA-seq) data …
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Development of screening assays to test novel integrin antagonists in allergic inflammation
… binds to a4b1 integrin and prevents eosinophil adhesion to VCAM-1, FN or human umbilical vein endothelial cells (HUVEC) cultured in vitro. Similarly, levocabastine affects aLb2/ICAM-1-mediated adhesion of Jurkat E6.1 cells. Analyzing the supernatant of TNF-a-treated (24h) eosinophilic …
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The Comparative Ultrastructure of the Choroid Plexus in Certain Animal Species
… of inclusion bodies are described: one kind, eosinophil bodies in the frog, and the other kind, large frothy bodies of lipid-like materials in the guinea pig. The eosinophil bodies proved to be identical in structure with the eosinophil granules of the blood and bone marrow eosinophil cells, …
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Phosphodiesterase 4 inhibitors for the treatment of inflammation associated with respiratory disease
… vivo model used was the guinea pig skin model of eosinophil recruitment, which involves systemic 111In-eosinophil recruitment to guinea pig skin induced by a range of inflammatory mediators [i.e. PCA, PAF and zymosan activated plasma (ZAP)]. Previous studies with PDE4 inhibitors had not examined …
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Vulnerable infants: Prediction and diagnosis of respiratory outcomes
… efficacy of an airway inflammatory marker, serum eosinophil cationic protein, in diagnosing asthma among children up to 5 years of age. Although a definitive role for serum eosinophil cationic protein in the diagnosis of asthma in young children <5 years was not established in this study because …
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The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
… randomisation analysis confirmed that a higher eosinophil count increased the risk of PR3-AAV but not MPO-AAV, and this effect might, in part, be modulated by MIR4435-2HG through prolongation of eosinophil survival. MIR4435-2HG encodes a long non-coding RNA that plays a critical role in the …
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Diet and diseases of Zion Canyon mule deer, Zion National Park, Utah
… not reveal any current infections, however, high eosinophil levels in 84% of animals tested were likely due to parasitism. Cysticeri of two species of Taenia, adult Elaeophora schneideri, and Sarcocystis hemionilatrantis were isolated in necropsies of two deer. Recruitment rates in Zion Canyon …
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Exacerbation and glucocorticoid toxicity profile in patients receiving mepolizumab for severe eosinophilic asthma
The treatment of patients with severe eosinophilic asthma has been transformed with the arrival of biological drugs targeting the type 2 cytokine pathway. One of these drugs is mepolizumab, a humanised monoclonal antibody against the eosinophil activating cytokine, interleukin (IL)-5, has …
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