Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"enzyme-substrate interactions"”.
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First Steps of Putting Research into Practice: Utilizing Concept Inventories to Identify Biochemistry Misconceptions and the Development of a Guided Inquiry Activity to Correct the Identified Misconceptions
… biochemistry students have a difficultly with enzyme-substrate interactions and the Enzyme-Substrate Interactions Concept Inventory (ESICI) has been developed to determine the most common misconceptions related to this topic. Using the ESICI, misconceptions were identified in a one-semester …
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Molecular specificity of substrate recognition and activation in cytochrome P-450(CAM)
… bonding. Hydrogen bonding and hydrophobic interactions have been implicated in binding and activation of hydrocarbon substrates by cytochrome P-450$\sb{\rm cam}$. The dependence of the reaction efficiency and specificity on the structural complementarity in the P-450$\sb{\rm cam}$-substrate …
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Tailoring Microenvironment and Orientation of Immobilized Lactase for Improved Catalysis at Suboptimal pH
… solution. Covalent immobilization allows enzymes to be reused and prevents contamination of the product. While immobilizing lactases has been found to enhance their pH and temperature stability, undesired enzyme-substrate interactions can still lead to reduced enzyme activity. This study …
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Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… dinucleotide or NAD. Since then, a family of 17 enzymes responsible for generating Poly-ADP-ribosylation or PARylation post translational modification has been identified and characterized. A unique member of this family of enzymes, called Poly-ADP-ribose Polymerases (PARPs), are Tankyrases. …
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Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… trafficking and function are regulated by the enzyme HIP14. Expansion of the polyglutamine tract in huntingtin as seen in Huntington Disease (HD) results in reduced association with HIP14 and decreased palmitoylation of huntingtin, which contributes to the formation of inclusion bodies and …
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Characterizing peptide-modifying enzyme activity in RiPP biosynthesis
… products. These dedicated peptide-modifying enzymes install heterocycles, macrocycles, acyl groups, halogens, and other moieties to endow biological functions and provide their producing organisms an evolutionary advantage. This thesis focuses on mechanistic and functional studies of such …
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Substituted aryl glycosides as probes of the mechanism of spontaneous ad enzyme-catalyzed glycoside hydrolysis
… used to probe the mechanisms of spontaneous and enzyme-catalyzed hydrolysis of 0-glycosides. The relative rates of spontaneous hydrolysis of the DNP glucosides followed the trend 4-deoxy > 3-deoxy - 6-deoxy > parent > 6-deoxy-6-fluoro > 3-deoxy-3-fluoro > 4-deoxy-4-fluoro > 2-deoxy-2-fluoro. …