Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"enzyme-responsive"”.
-
Enzyme responsive nanomaterials for cancer applications
Expression levels of enzymes dictate the difference between health and disease in many cases, including cancer. This leads scientists to explore strategies to incorporate enzyme sensitivity in materials where the goal is to achieve dynamic and targeted changes in material properties to influence …
-
Characterization of Triggerable Quinones for the Development of Enzyme-Responsive Liposomes
… applications. From all of the carriers, stimuli-responsive liposomes have been studied extensively, but only a handful have been enzyme-responsive liposomes. Therefore, the field of endogenous proteins as activators of liposomes is a fertile field worthy of exploration. The research described in …
-
Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents
<p>Enzyme-responsive materials have been well explored, particularly as therapeutic and diagnostic agents. In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as …
-
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… of prostate cancer relevant antigens and enzyme for targeted drug delivery. We also discussed the role of the BBB as a major hurdle in drug delivery to the brain, and the identification of peptide ligands using phage display. In chapter 3, an enzyme-responsive peptide drug conjugate was …
-
The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
… The second half explores the emergence of enzyme-responsive nanomaterials in an attempt to develop a PET imaging agent for MMP-9 activity.</p>
-
Stimuli-Responsive Peptide-Based Biomaterials: Design, Synthesis, and Applications
… relevant to biology and medicine. Stimuli-responsive peptide-based biomaterials can respond to environmental stimuli, such as light and ultrasound, in addition to local environmental factors, such as temperature, enzyme activity, and pH. Under environmental changes, these materials can be …
-
Chemical strategies for improving anti-diabetic glucagon therapy
… modification of glucagon to produce enzyme-responsive pro-glucagons. They are observed to remain stable in solution for longer periods and therefore, can be potentially used to develop pump-based bi-hormonal artificial pancreas and more.
-
Peptide functionalisation and characterisation of gold (nano) surfaces
… gold surfaces, with a focus towards developing enzyme response applications. The serine protease, elastase, was the primary focus of this work; however, all of the systems described herein have the utility to be modified for alternative proteolytic enzymes. 1.0 provides background and context to …
-
Leveraging Bio-Inspired Molecules for Cancer Theranostics
… of those cells. Matrix metalloproteinase (MMP) enzymes are over-expressed by some metastatic cancers, in which they are responsible for the degradation and remodeling of the extracellular matrix. In recent years, MMPs have emerged as promising targets for enzyme-responsive diagnostic probes …