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Showing 1 to 10 of 10 for “"enzyme regulation"”.
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Beta-Galactosidase: A Possible Model Enzyme for Studying the Genetics of Enzyme Regulation in Mammalian Systems
Made available in DSpace on 2014-12-14T15:38:02Z (GMT). No. of bitstreams: 1 7624126.pdf: 3286208 bytes, checksum: 0672cacc55267684c7bf8a3730256c70 (MD5) Previous issue date: 1976
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Investigating the Role of Conformational Flexibility in tRNA Aminoacylation
… to Koshland's classical "induced fit" model of enzyme regulation, proteins have essential conformational flexibility for ligand binding, which promotes catalysis by structural rearrangement. Proteins undergo structural rearrangements to bind ligands, regulate access to a catalytic site, or …
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Initiation, Maintenance, and Termination of Bursting in an Endogenously Bursting Molluscan Nerve Cell (cyclic-Amp)
… of phosphodiesterase (PDE; the degradative enzyme for cAMP) increases the peak amplitude. Protein kinase and phosphatase decrease and increase, respectively, the peak amplitude, but neither significantly changes the duration. Mathematical modeling of the major enzymatic steps elicited by …
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Molecular Mechanisms of HIV-1 Infection: Viral and Host Determinants in Transmission and Pathogenesis
… maintenance of intracellular environment, enzyme regulation, cellular metabolism, catalytic activity and cation transport. Numerous potential transcription factors binding sites at the site of integration were identified. Furthermore, the genes at integration site, transcription factors …
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Computational analysis of biochemical networks for drug target identification and therapeutic intervention design
… (Chou TC, Talalay P (1984), Advances in enzyme regulation 22: 27-55) for our system and systematically perturbing biochemical pathway, we explore the range of combination behaviors for all plausible combination targets. This holistic approach reveals that most target combinations show …
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Evidence for reversible phosphorylation as a post-translational regulatory mechanism in the chlorophyll catabolic pathway
… safe compounds through a series of enzyme-mediated steps. Although these steps have all been identified, little is known about their regulation, particularly at the post-translational level. A better understanding of the post-translational mechanisms governing activity of one enzyme …
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
… via liquid–liquid phase separation (LLPS). Dysregulation of these MLOs or “biomolecular condensates” is increasingly linked to human disease, including cancer and neurological disorders. Human SMAUG1 (SAMD4A) is a conserved translational repressor and condensate-forming protein implicated in …
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Is metabolism goal-directed? Investigating the validity of modeling biological systems with cybernetic control via omic data
… in that they describe the time-dependent regulation of cellular reactions in terms of dynamic "metabolic goals." This approach contrasts starkly with purely mechanistic descriptions of metabolic regulation which seek to explain metabolic processes in high resolution — a clearly daunting …
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Yeast Chorismate Mutase: Molecular Evolution of an Allosteric Enzyme
… widerlegt, dass die Chorismatemutase an der Osmoregulation und Vakuolenentstehung beteiligt ist. Die Analyse einiger Stämme mit punktmutiertem oder deletiertem ARO7-Gen zeigte ausschließlich eine Funktion in der Aminosäure-Biosynthese. Die Fusion an das grün-fluoreszierende Protein ermöglichte …