Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"enzyme model"”.
-
The synthesis of a cyclic octapeptide for study as an enzyme model
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Zinc enzyme model complexes with Ligands containing a N2S Donor Set and their methylating reactions
… been used for the syntheses of 47 new zinc <br>enzyme model complexes. These complexes have been characterized and compared <br>by IR and NMR spectroscopy, 14 of them with single crystal structure analysis. <br>9 of the mononuclear tetrahedral N2S2 coordinated zinc complexes have been …
-
Computational Modeling of Catalytic Mechanisms of Glycyl Radical Enzymes
… the catalytic mechanisms of three glycyl radical enzymes. The mechanism of the B(12)-independent glycerol dehydratase has been elucidated by combining continuum electrostatic and density functional theory calculations. A mechanism for the dehydration of glycerol is proposed that does not involve a …
-
Spatio–temporal analysis of changes of shape for constituent bodies within biomolecular aggregates
… different typical length scales. Approaches for modelling the behaviour of droplets in suspension and thermallydriven motion of the molecular chains in enzymes are presented. Both models use orthogonal basis functions to describe the spatial dependences in a spherical geometry. Both models also …
-
Elucidation of the reaction mechanisms involved in the catalysis mediated by glutamine synthetase in Escherichia coli
… which the adenylylation/deadenylylation of the enzyme affects the enzyme specificity for either MgATP or Mn2ATP and NH4+ or NH3, is by switching between two putative serine protease-like catalytic triads. Site-directed mutagenesis of a number of residues identiï¬ ed as playing a role in these …
-
Impact of CYP2C8 single nucleotide polymorphisms on in-vitro metabolism of imatinib to N-desmethyl imatinib
… pooled HLM, and in expressed CYP2C8 and CYP3A4 enzymes. Effects of CYP-selective chemical and antibody inhibitors on N-demethylation were also determined. A single enzyme Michaelis-Menten model with substrate inhibition best fitted wild-type CYP2C8*1/*1 HLM kinetic data (median ± SD K𝚒 = 139 ± …