Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"enzyme inhibitor"”.
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In search of human cytochrome P450 1A1 enzyme inhibitor
… been seen in human tissues. All three CYP1A enzymes have been widely studied for different reasons. The CYP1A1 enzyme is known to be induced by xenobiotics and poly-aromatic hydrocarbons (PAHs). Induction of CYP1A1 results in its involvement in Phase 1 biotransformation of xenobiotics and in …
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On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
Protein kinases are important regulatory enzymes in signal transduction and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases. I have developed a statistical approach based on the Mantel …
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Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
BACKGROUND: The fact that angiotensin-converting enzyme inhibitors(ACEI) and angiotensin receptor blockers(ARB) antagonize the renin-angiotensin system at different levels suggests that these agents, already confirmed by clinical benefit in retarding the progression of chronic renal disease, may …
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Improving protein docking with binding site prediction
… PINUP, Promate, and SPPIDER, which predict enzyme-inhibitor interfaces with success rates of 23% to 55% and other interfaces with 10% to 28% on a benchmark dataset of 62 complexes. After refinement, metaPPI significantly improves prediction success rates to 70% for enzyme-inhibitor and 44% …
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Synthesis and MAO activity of a series of benzimidazolyl and indazolyl prodrugs
… in the substantia nigra of the brain. A key enzyme that has been associated with the neurodegeneration seen in PD is monoamine oxidase-B (MAO-B). Several inhibitors of this enzyme have resulted in neuroprotection in the mouse model of PD. One such compound is 7-nitroindazole (1). This thesis …
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Enzymes as Drug Targets in the Isoprenoid Biosynthesis Pathway: Structure, Mechanism and Inhibition
Enzymes in isoprenoid biosynthesis pathway play important roles in all living organisms. Several of them have been identified as drug targets. Here we reported the inhibition study of isopentenyl diphosphate/dimethylallyl diphosphate isomerase (IPPI) and deoxyzylolus reductoisomerase (DXR), along …
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Investigating the structure-function relationships of Plasmodium Haem Detoxification Protein and Phosphatidylinositol 4-kinase
… ATP-competitive and covalent Plasmodium PI4Kβ inhibitors. Two residues of interest in Plasmodium vivax PI4Kβ unique to Plasmodium, F832 and C1327, were mutated to alanine. F832 is thought to form key Pi-Pi interactions with inhibitors and C1327, found on the periphery of the catalytic site, is …
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Investigation of protein-protein interaction using atomic force microscopy
… the extended theory to investigate relevant enzyme-inhibitor systems under physiological conditions.</p>
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The pathway of nitrogen assimilation in Datura stramonium L
… investigated using 15N tracer experimentation, enzyme inhibitor studies and enzymological assays. Leaves were fed via their xylem stream with potassium nitrate at -1 -1 two concentration levels: 200 pg. N. ml and 25 JJ8 N. ml , prior to experimentation. Nitrate-15N xylem stream and infiltration …
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Evaluating adherence to recommended clinical guidelines for the prevention of cardiovascular disease in patients with Type 2 diabetes mellitus at primary care level
… medication - an Angiotensin Converting Enzyme Inhibitor (ACEI). There was appropriate supporting documentation for only 39% not on first line therapy. A fifth (22%) with drug intolerance received the recommended alternative. Most were appropriately prescribed a statin (74%) and aspirin …
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Evaluation of bioactivity of a peptide QUB-1669, from the skin secretion of the African running frog, Kassina senegalensis
… antibacterial effects, anticancer effects, enzyme inhibitor effects, smooth muscle inhibition or relaxation effects, etc., and they are also the current research hotspots of many scientists. <br/><br/>In this experimental study, a new pharmacologically active peptide QUB-1669 was studied. …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… characterizes the role of a lysosomal enzyme inhibitor, Cystatin C (CysC), in an animal model of multiple sclerosis (MS), called experimental allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central …
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Repression of telomerase components in isogenic normal, immortal and tumorigenic cells
The telomere maintenance enzyme telomerase is a ribonuclear protein complex that is active in 80-90% of immortal cancer cells. Three essential components of the active telomerase holoenzyme include the reverse transcriptase, hTERT, an RNA component (hTR) that has a template region for reverse …
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Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system.
… HDAC assay kits, as a potent and selective SIRT2 enzyme inhibitor, thus, identifying, a novel structural backbone for the selective inhibition of HDAC enzymes.
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Impact Of Time-Varying And Time-Invariant Measures Of Adherence To Secondary Prevention Therapies Post-Acute Myocardial Infarction: An Application Of Marginal Structural Models (MSMS)
… therapy) and C (angiotensin converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) therapy) included 1,021 and 1,025 patients, respectively. When accounting only for baseline covariates in a discrete-event time model the hazard for a recurrent AMI among statin adherent …
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The effects of right ventricular pacing in the heart failure population
… receptor blocker or angiotensin converting enzyme inhibitor use <br/>was associated with improved mortality and less hospitalisation for heart <br/>failure in patients paced for complete heart block, who were likely to be <br/>exposed to high degrees of right ventricular pacing. <br/>In …
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Establishing models of and characterising the genomic context of neutrophil hypersegmentation
… of the impact of the angiotensin converting enzyme inhibitor (ACEi) captopril, glucose concentration, and hypoxia. Furthermore, the current work outlines the optimisation of a laser capture microdissection (LCM) technique for the isolation of neutrophils, based on their morphologic phenotype, …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… determining if use of an angiotensin converting enzyme inhibitor (enalaprilat) would ameliorate the apoptotic response. It was designed to determine if mucosal epithelial cells undergo apoptosis during the ischemia phase and also examined if apoptosis is significantly exacerbated by reperfusion. …
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Epigenetic Mechanisms in Blast-Induced Neurotrauma
… was accompanied by decreased expression of the enzyme responsible for facilitating the addition of methyl groups to DNA. The one week time point also showed dramatic decreases in histone acetylation which correlated to decline in memory. This change was observed in astrocytes and may provide a …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… there are no studies evaluating specific inhibitors of endocannabinoid catabolic enzymes in ICSS in any species. In these studies we assessed the cannabinoid agonist THC, as well as the fatty acid amide hydrolase (FAAH) inhibitor, PF-3845, the monoacylglycerol lipase (MAGL) inhibitor …
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