Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"enzyme induction"”.
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ENZYME INDUCTION BY THE PORPHYRINOGENIC DRUG ALLYLISOPROPYLACETAMIDE.
ENZYME INDUCTION BY THE PORPHYRINOGENIC DRUG ALLYLISOPROPYLACETAMIDE.
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Monoterpene Metabolism: Aspects of Assimilation and Patterns of Enzyme Induction
Made available in DSpace on 2014-12-05T19:38:05Z (GMT). No. of bitstreams: 1 6303203.pdf: 2801575 bytes, checksum: 4db643636ed33d112565f3cdf7a6fda9 (MD5) Previous issue date: 1962
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Polychlorinated biphenyl effects on avian hepatic enzyme induction and thyroid function
… in rats and mice by inducing activity of a liver enzyme, uridine diphosphate-glucuronosyltransferase (UDP-GT), thereby increasing thyroxine (T4) clearance. This loss of T4 can lead to hypothyroidism. In this study, an assay was validated for measuring UDP-GT activity toward T4 in Japanese quail …
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Microsomal Enzyme Induction by Ddt and Its Analogs in the Mouse and Chicken
Made available in DSpace on 2014-12-11T18:05:41Z (GMT). No. of bitstreams: 1 7310014.pdf: 3252442 bytes, checksum: 527e0ed18cd2cf59436f5b95f73371b0 (MD5) Previous issue date: 1972
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Enzyme Induction and Repression in the Catabolism of (positive)-Camphor by Pseudomonas Putida
Made available in DSpace on 2014-12-09T17:35:50Z (GMT). No. of bitstreams: 1 6801778.pdf: 3632388 bytes, checksum: 067f46e1a5e55391c59afd02a1e5325a (MD5) Previous issue date: 1967
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… via upregulation of the phase I detoxification enzyme cytochrome P450 (CYP) 1A. Broccoli inhibited growth of human prostate and ovarian cancer cells via induction of apoptosis, but this was not due to formation of 2-methoxyestradiol. Compared to the purified glucosinolate breakdown products I3C …
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Urinary ascorbic acid excretion and sugar consumption as indices of enzyme induction and hypoglycemia in recovering alcoholic rats
… collected at the end of the baseline, alcohol-induction, and recovery periods and analyzed for L-ascorbic acid. The mean consumption of sucrose was highest for rats still receiving alcohol and declined in all groups during the 10 days. The mean consumption of sucrose (% kcal as sucrose) for the …
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Effects of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels in prepubertal female rats
… of polychlorinated biphenyls (PCBs) on hepatic enzyme induction, uterotropic responses, and thyroid hormone levels. Three approaches have been used to study the multiple effects of PCB mixtures: (1) environmental mixtures (soil, dust and air samples) collected from the Sangamo landfill site were …
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Regulation of Hepatic Detoxification Enzymes by Glucosinolate Breakdown Products in Cruciferous Vegetables
… and I3C that explains the synergism in phase II enzyme induction after exposure to combinations of these two components. In addition to this, active glucosinolate breakdown products studied here also have anti-promotional effects through inhibition of AP-1 induced tumor promotion in vitro.
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SYNTHESIS AND CHARACTERIZATION OF RESVERATROL AND ITS CONJUGATED METABOLITES AND CONTRIBUTION OF METABOLISM TO ITS DECREASED BIOVAILABILITY
… and recombinant supersomes over-expressing the enzymes (UGTs) of interest were used for these studies. Our results show the presence of atypical kinetics for the formation of resveratrol glucuronides across most of the protein sources used. Prior to this study, the full glucuronidation kinetics …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… inflammation can be reduced via phase 2 enzyme induction. Broccoli sprouts, a rich source of phase 2 enzyme inducers such as isothiocyanates, can be incorporated into the diet to increase phase 2 enzymes. The hypothesis of this study is that, the dietary intake of dried broccoli sprouts, …
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Thiopurine methyltransferase phenotyping and genotyping in clinical practice preferred access arrangement
… thiopurine drugs. The activity of this enzyme varies between individuals and this can influence treatment success. Rapid and accurate assays of TPMT and 6TGN, the active thiopurine metabolites, are increasingly recognised as valuable clinical tools, to guide dosing and treatment. This …
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Blood characteristics as predictors of reproductive success in quail species exposed to DDT
… ratios in livers, a means of estimating liver enzyme induction, were calculated. The DDE/DDT ratios in livers of Japanese quail and northern bobwhites were found to be markedly different. More work needs to be done to better evaluate the relationship between differences in enzyme induction and …
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I. Radical Cyclizations Mediated by Transition Metal Hydrides II. Study toward the Total Synthesis of Pluraflavin A III. Cytoprotective Polyacetylenes Inspired by Panaxytriol
… for their ability to induce cytoprotective enzymes by the Nrf2 cell-signaling pathway. The resulting structure-activity relationship suggested that the diyne and propargylic hydroxyl functionalities are necessary for phase II enzyme induction. While we have not yet necessarily attained the …
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Development of an in vitro drug recovery model for paediatric tuberculous meningitis using microdialysis with in vivo application
… (Cmax) in microdialysate was 221 ng/mL before enzyme induction (where drug administration had just started) and 100 ng/mL after enzyme induction (where the patient had been on Rifampicin for more than two weeks). The time of the peak (Tmax) in microdialysate was 11 hours after drug …
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In vivo and in vitro toxicity of M-741 (3,15 di-(5,5-dimethyl-3-N(-(cyclopropylmethylinium)-(N-propylinium));-1-cyclohex-1-enyl);-7,11,18,21-tetraoxa-3,15-diazatrispiro (5.2.2.5.2.2); heneicosane)
… of nutritional status (fasting), hepatic enzyme induction (phenobarbital) or interference (glutathione depletion) with potential detoxication pathways. The M-741 pharmacokinetic profile is best described by a three compartment model and displays a rapid distribution and terminal …
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The determination and environmental significance of planar aromatic compounds in the marine environment.
… in sediments was also determined as P450 enzyme induction produced by sediment extracts in H4IIE cell cultures. The highest toxicity was found in sediments originating from the sewage sludge dump site. When correlating the TEQs from chemical analysis and from cell culture toxicity, the …
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Temporal and Spatial Assessment of PAHs in Water, Sediment, and Oysters as a Result of the Deepwater Horizon Oil Spill
… clot, edema and tube heart), and cytochrome P450 enzyme induction was measured by an in ovo ethoxyresorufin-O-deethylase assay. <italic>F. heteroclitus</italic> embryos were not significantly affected by the water collected from these sites. There was less than 4% and 2% incidence of edema and …
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Cellular Activities During Aging in Mammals
… revealed by a study of three parameters. (1) The induction of liver tyrosine aminotransferase (TAT), an enzyme shown to be rapidly induced in a gene-mediated reaction during cold stress in young mice (4-16 months old) was delayed up to 2 hours in senescent mice (26-28 months old); the rate of …
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Dual Delivery Systems Based On Polyamine Analog Benspm As Prodrug And Gene Delivery Vectors
… such as to up-regulate polyamine metabolism enzymes and down-regulate polyamine biosynthesis enzymes. Therefore BENSpm depletes all natural polyamines and leads to apoptosis and cell growth inhibition in a wide range of cancers; (3) preclinical studies proved that BENSpm can act …