Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"enzootic cycle"”.
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Characterization of cyclic di-GMP binding by the sole Borrelia burgdorferi and Borrelia hermsii PilZ domain-containing proteins
… These spirochetes are maintained in an enzootic cycle, involving tick vectors and mammalian hosts. Differential gene expression is central in their survival in various environmental conditions. C-di-GMP has been demonstrated to be important in bacterial adaptation. Borrelia deletion …
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Uncovering the Redox Potential of the Global Gene Regulatory Protein DksA in Borrelia burgdorferi
… vector-borne illness in North America. The enzootic cycle of B. burgdorferi involves transmission between Ixodes species tick vectors and vertebrate hosts. This infectious cycle requires the spirochetal bacteria to undergo dramatic shifts in gene expression in order to survive and remain …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… In nature, B. burgdorferi is maintained in an enzootic cycle between Ixodes ticks and mammalian hosts. In order to cause infection in mammals, B. burgdorferi spirochetes within a feeding tick sense environmental changes and subsequently alter their gene expression and protein profiles. As part …
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A Molecular Genetic Investigation of the Regulation of Outer Surface Protein C in Borrelia Burgdorferi: Identification and Characterization of the Novel Regulatory Protein BBD18
… In nature, B. burgdorferi is maintained in an enzootic cycle between Ixodes ticks and mammalian hosts. In order to cause infection in mammals, B. burgdorferi spirochetes within a feeding tick sense environmental changes and subsequently alter their gene expression and protein profiles. As part …
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Characterization of cyclic-di-GMP signaling with the Lyme spirochete, Borrelia burgdorferi
… mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger, is a key modulator of B. burgdorferi adaptive responses and may play a significant role in cycle progression. In this study, we examined …
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Coping with stress: How Reactive Oxygen and Nitrogen Species alter the transcriptional landscape of the Lyme disease spirochete Borrelia burgdorferi
… signals sensed by B. burgdorferi to navigate the enzootic cycle. As tight regulation of RpoS and its associated genes enable B. burgdorferi to complete the enzootic cycle, ROS/RNS could serve as crucial negative regulating signals when the bacteria transitions between the mammalian host and tick …
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Transmission Competence of B. burgdorferi Infected Ixodes Ticks and Development of an OspC-Based Lyme Disease Vaccine
… fit to fulfill their transmission role in the enzootic cycle of Bb. We wanted to check for differences in Bb infection prevalence between the questing (actively moving and looking for hosts on which to feed) and diapausal (in suspended development) nymphs over a year. Our second objective is to …
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Sylvatic dengue: evolution, emergence, and impact on human health
… the world. Transmission includes a sylvatic, enzootic cycle between nonhuman primates and arboreal mosquitoes of the genus Aedes, and an urban, endemic/epidemic cycle between Aedes aegypti, a mosquito with larval development in peridomestic water containers, and human reservoir hosts. All 4 …
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Analysis of the role of outer surface protein C (OspC) in Borrelia burgdorferi pathogenesis
… These bacteria exist in nature through an enzootic life cycle involving Ixodes ticks and various reservoir hosts. One way that this bacterium adapts to the different hosts in the enzootic cycle is through the expression of outer surface protein C (OspC). OspC is a surface exposed …
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Evolutionary influences on the reduction in enzootic circulation and human incidence of western equine encephalitis
… mutations have a phenotypic effect on WEEV’s enzootic hosts. Using competitive fitness assays, contemporary mutations have a competitive advantage in Culex tarsalis and possibly house sparrows. Additionally, these mutations have no effect on virulence in the Syrian golden hamster. Given this …
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Determining the Pathogenesis and Enzootic Transmission of Usutu Virus
… humans and wild birds. USUV is maintained in an enzootic cycle between wild birds, primarily passerine species, and ornithophilic mosquitoes, predominantly Culex spp. mosquitoes. Since its first isolation in 1959 in South Africa, USUV has spread throughout sub-Saharan Africa and Europe. Its …
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Transmission of West Nile virus in the Niagara Region among a population at risk for exposure
… disease in Mexico. Since WNV persists in an enzootic cycle in Niagara and the occurrence of future outbreaks is unpredictable, the agricultural workers remain at risk for transmission. Therefore it important they receive sufficient health education regarding WNV before leaving Mexico and …