Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"environmental estrogens"”.
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and o¡¯,p¡¯-dichlorodiphenylethylene (DDE)], plastics manufacturing by-products/detergents (nonylphenol, …
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Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
… that can be used as potential biomarkers of environmental estrogen exposure are still needed since angiotensinogen is not specific to estrogens and thus cannot be used alone.
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Zebrafish as a Model for Studying Estrogen Signaling and Estrogenic Endocrine Disruption
… using Tg(5xERE:GFP) reporter fish. A total of 26 environmental estrogens and 62 clinical drugs with estrogenic activities were identified from these two libraries. Then environmental estrogens identified from reporter zebrafish assays were compared to xenoestrogen datasets from in vitro assays, …
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Dissecting the spatio-temporal development of the human reproductive tract
… tissues can mount transcriptional responses to environmental estrogens. 3 By mapping the sex-specific regionalisation and differentiation of the reproductive tract at single-cell resolution, this thesis provides a foundational resource and reveals previously uncharacterised cellular trajectories …
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Steroid hormone regulation of fetal mouse oocyte development
… (P4) or E2 mimicking chemicals known as xenoestrogens such as Diethylstilbestrol (DES) and Bisphenol-A (BPA) delay cyst breakdown and follicle formation. The overall goal of this dissertation project is centered on the pivotal question: "What is the source of steroid hormone signaling and its …
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Novel tools to identify estrogen regulated genes important for breast and ovarian cancer cell proliferation
Estrogens are steroid hormones produced by the ovaries and extra ovarian tissues including the adrenal gland and adipose tissue. There are 3 major physiologically relevant estrogens in the human body, the most potent and biologically relevant of which is 17 -estradiol (E2). E2 exerts its …
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A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
… is known about the molecular pathogenesis of UL. Environmental estrogen exposure is one of the most recognized risk factors associated with the development of UL tumors. At the cellular level, extensive evidence has linked the cell proliferation, survival and growth of UL tumors to the …