Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"enveloped virus"”.
-
A role for myotubularins in vaccinia virus egress
Vaccinia virus (VACV) generates multiple distinct forms of infectious virus. Intracellular mature virus (IMV) particles are surrounded by a single lipid membrane and are mostly released upon lysis of the infected cell. Some IMVs are wrapped by an additional double membrane to form intracellular …
-
Secretion of the rotavirus VP7 capsid glycoprotein from polarised epithelial cells
Despite the widespread implementation of rotavirus vaccination, rotaviruses remain a major cause of severe diarrhoeal disease in infants and young children worldwide. Rotavirus is a double-stranded RNA (dsRNA) non-enveloped virus that infects polarised epithelial cells lining the upper region of …
-
Viability of Viruses in Suspended Aerosols and Stationary Droplets as a Function of Relative Humidity and Media Composition
… effects of these stressors on the viability of viruses have not been extensively studied. The overall objective of this work was to investigate the effects of RH and media composition on the viability of viruses in suspended aerosols and stationary droplets. We used a custom rotating drum to …
-
Multi-modal imaging of herpesvirus infection
Herpes simplex virus (HSV)-1 is a large, enveloped DNA virus that undergoes a complex assembly pathway in the cell. Capsids assemble in the nucleus, cross the nuclear envelope into the cytoplasm by budding and fusion through the nuclear membranes, and acquire a proteinaceous ‘tegument’ layer in the …
-
Development of a plant-made immunoassay for the detection of Porcine circovirus infections in South African swine herds
Porcine circovirus type 2 (PCV-2) is considered the major cause of porcine circovirusassociated diseases and is one of the major pathogens in swine producing countries. PCV-2 is a non-enveloped virus with a single stranded circular DNA genome of about 1.8 kb. This encodes the single capsid protein …
-
Cryo-EM reveals how adeno-associated virus engages its receptor AAVR and an investigation of the GPR108 ectodomain
Adeno-associated virus is one of the leading delivery agents used in gene therapy today. While it is already used in the clinic, some aspects of its basic biology are still not yet fully understood. Only recently in 2017 was the primary receptor for most AAV serotypes discovered and there are still …
-
Impact of mutations in non-structural proteins on SARS-CoV-2 replication
… of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that led to the unprecedented COVID-19 pandemic, with profound global health and socioeconomic impacts. This thesis offers a thorough examination of the molecular biology, evolution, and disease-causing mechanisms of SARS-CoV-2, …
-
Mechanism and Evolutionary Origins of HIV-1 Virion Entrapment by Tetherin
… factor, tetherin, prevents HIV-1 and other enveloped virus particles from being disseminated into the extracellular milieu by infiltrating their envelopes and by physically crosslinking them to the cell surface. However, the mechanisms underlying virion retention have not yet been fully …
-
The elaborate interplay of natural killer cells and vaccinia virus
Vaccinia virus (VACV) is a poxvirus and is the vaccine used to eradicate smallpox. It is also an expression vector for heterologous antigens and an oncolytic virus for cancer therapy. VACV encodes multiple proteins that aid evasion of the host immune response. There is, however, an incomplete …
-
Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
BK polyomavirus (BKPyV) is a small, non-enveloped dsDNA virus that infects 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop …
-
Understanding the Role of the Hypervariable Region in the Open Reading Frame 1 of the Hepatitis E virus in Viral Replication
Hepatitis E virus (HEV) is a major cause of enterically transmitted acute viral hepatitis in developing countries that lack proper hygienic infrastructure. Hepatitis E is globally distributed and has emerged as an important public health disease in both developing and industrialized countries. HEV …