Global ETD Search
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Showing 1 to 5 of 5 for “"entropic cost"”.
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Activation processes in biology
… I show that there is a trade-off between the entropic cost of reaching to a receptor vs the volumetric cost of expanding the tether length. I then show that for a Gaussian chain with multiple ligands along its length, there exists a finite, non-zero optimal number of ligands to minimise the …
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Water in Protein Cavities: Free Energy, Entropy, Enthalpy, and its Influences on Protein Structure and Flexibility
… show that addition of thewater molecules is entropically unfavorable, with values that are comparable to the measuredentropy differences. The free energies and entropies correlate with the change inthe number of hydrogen bonds due to the addition of water molecules.To examine the wide variety …
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Folding and aggregation of amyloid peptides
… a loss in entropy. Approximately 25 % of the entropic cost correspond to configurational entropy. The rest relates to solvent entropy, presumably caused by hydrophobic and electrostatic effects. In contrast to the transition towards fibril-like dimers the first step of aggregation is driven by …
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EFFECT OF MISMATCHED BASE PAIRS ON DNA PLECTONEMES
… repair protein. In genomic DNA, however, the entropic cost associated with plectoneme localization could make pinning unfavorable. Magnetic-tweezers-based studies of DNA supercoiling, performed at high salt concentrations, have shown that in DNA harboring a single mismatch, the plectoneme will …
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Probing the Role of Nascent Helicity in Protein Function: p27kip1 as a Regulator of the Cell Cycle
<p>p27<sup>kip1</sup> binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal …