Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"enterovirus"”.
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UNDERSTANDING THE NEUROVIRULENCE OF ENTEROVIRUS 71
NITD008, an adenosine nucleoside analog, was shown to fully protect EV71-infected two-week old AG129 mice from morbidity and mortality. NSC-34, a murine motor neuron cell line, was found to be susceptible and permissive to EV71 infection, with S41 strain being the most infectious in NSC-34 cells …
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Bovine parvovirus and bovine enterovirus in mixed infections
… were infected with bovine parvovirus and bovine enterovirus in order to study the events occurring when DNA and RNA viruses mixedly infect single cells. The objectives of this research were threefold. First, to determine the effects of single infection of synchronized bovine fetal spleen cells by …
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
The Enterovirus genus includes many known and emerging pathogens, such as poliovirus, enteroviruses A71 and D68, rhinoviruses, and others. Enterovirus infection induces the massive remodeling of intracellular membranes and the development of specialized domains harboring viral replication …
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STUDYING THE INTERACTION OF NANO- & MICROPLASTICS WITH ENTEROVIRUS AND THEIR CYTOTOXICITY ON HUMAN LUNG CELL LINE
… This study investigated the interaction between enterovirus D68 (EV-D68) and charged nano- and microplastics, as well as the chronic effects of positively charged mixed polymer nanoplastic particles on a human lung cell line. Positively charged poly(methyl methacrylate) (PMMA) surfaces exhibited …
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Translational Regulation in the 5′UTR of Enteroviruses
The genus Enterovirus consists of a large group of positive-sense RNA viruses, with over 100 serotypes known to be human pathogens. Disease phenotype in humans ranges from sub- clinical to acute flaccid paralysis and treatment options for infection with these viruses are limited, with only few …
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Pharmacology of novel approaches designed to target picornaviral infections
Many Picornaviridae family members infect humans. Enterovirus (EV), the largest genus, causes diseases ranging from the common cold to fatal heart disease and paralysis. Human parechoviruses (HPeV) are at least as prevalent as EVs. Currently, no antipicornavirus drugs are used clinically and the …
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Quantification of multiple waterborne pathogens in drinking water, drainage channels, and surface waters in Kampala, Uganda over seven months of seasonal variation
… spp., Salmonella spp., Vibrio cholerae, and Enterovirus. Drainage channels were found to be significantly more contaminated during the wet season compared to the dry season, whereas drinking water sources contained little to no seasonal variation. These results suggest that individual water …
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Structural Basis For Poliovirus Cloverleaf-Mediated Regulation Of Genome Replication
Poliovirus is a member of the Enterovirus genus, members of which are characterized by small, non-enveloped capsids containing short, positive-sense single-stranded RNA genomes. During the viral replication cycle, it is critical that the virus generates the appropriate amounts of viral proteins and …
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Sensing of Picornavirus Infections
… picornaviruses of the cardiovirus and the enterovirus genus respectively, are sensed by both MDA-5 and RIG-I. Sensing of these viruses in macrophages leads to the expression of type I IFN early after infection with IFNβ expression reduced in the absence of each sensor, and IFNα; expression …
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The effect of Coxsackie virus A9 infection on nuclear and nucleolar proteins
… and most medically-important picornavirus genera Enterovirus, which is genetically divergent from Parechovirus. Using an EGFP-PSPC-1 fusion, we found that infection changes the distribution of PS PC-1 from nuclear paraspeckles to cytoplasmic granules that do not seem to correspond to known …
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Detection of enteroviruses in marine waters using RT-PCR.
… optimization of methods for RT-PCR detection of enteroviruses in marine waters, with particular attention to the issue of sensitivity vs inhibition (ii) comparison of enterovirus detection in marine waters by cell culture and RT-PCR and (iii) development of a method for detecting infectious …
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Caracterización de comunidades virales en muestras fecales de bovinos de la provincia de Ubaté, Cundinamarca, Colombia
… de especie los virus más abundantes fueron el Enterovirus E (EVE) y el Astrovirus Bovino (BoAstV). Notificamos por primera vez en Colombia virus de importancia veterinaria con frecuencias significativas: EVE (59%), KVB (52%) y BoAstV (19%), además de la confirmación de CRESS Virus en heces de …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
… human enteric viruses, through evaluating human enterovirus 71 (EV71) infection and immunity, and vaccine and therapeutics for human rotavirus (HRV). Gn pigs could be infected via oral or oronasal route, the natural route of infection. Infected pigs developed clinical signs including fever, …
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Cell surface interactions of Coxsackie A9 virus
… and disease. Coxsackievirus A9 (CAV9), an enterovirus, harbours an integrin- recognition motif, RGD (Arg-Gly-Asp), in the capsid protein VP1 and although modes of transmission and pathogenesis are still largely unknown, this motif is believed to be primarily responsible for integrins αvβ6 …
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The use of molecular diagnostic methods to improve the detection of the common bacterial and viral causes of community acquired meningitis in children in South Africa
… pneumoniae (lytA gene) and viral causes namely: enterovirus (5' UTR), herpes simplex (UL30 gene) and mumps virus (Fusion protein gene). The qPCR assays were carried out on the Biorad CFX 96 real-time instrument. These validated assays were used to screen a cohort of suspected meningitis cases. …
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Investigation on donkey milk protein fractions: in vitro antimicrobial, antiviral and anti-proliferative activities and casein separation by cation exchange chromatography
… che è stata testata in vitro su un tipo di enterovirus, echovirus 5, in due prove sperimentali. I risultati ottenuti hanno mostrato un forte effetto inibente sulla replicazione virale delle proteine del siero, probabilmente dovuta al sinergismo tra tra i suoi componenti. Lo studio …
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Human Adenoviruses As Indicators Of Faecal Contamination And Pathogen Indices In The Environment And Shellfish
… assessment of guanidine hydrochloride to inhibit enterovirus growth in virus quantification assays. The presence, quantity, and where possible, infectivity (using HEK-293 cells in a culture-qPCR assay with guanidine hydrochloride) of HAdVs were determined in a range of environmental samples and …
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The roles of papain-like protease-related proteins in viral replication and host immunity
… event, in which the chimeric picornavirus-enterovirus G expresses the PLP gene, homologous to torovirus (ToV) PLPs. Like other nidoviral PLPs, the recombinant ToV-PLP was proved to be a highly active deubiquinase/deISGylase and potent innate immune antagonist. After PLP knockout, viral …
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Factors That Influence Mammalian Enteric Virus Infection
… of picornaviruses from three different genera: Enterovirus (PV and coxsackievirus B3 (CVB3)), Kobuvirus (Aichi virus) and Cardiovirus (Mengo virus). I determined that specific bacterial strains enhance thermal stability of subset of viruses, while others were stable in the absence of bacteria. …
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Triggers of autoimmunity. Studies on gestational events.
… chemokine (early pregnancy samples), IgM class enterovirus (EV) antibodies and EV-RNA (early pregnancy samples). Study I-IV Study I: The objective of our first study was to determine seroconversion to islet autoantibodies in non-diabetic mothers during pregnancy. This was achieved by analyzing …
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