Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"enteropathy"”.
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… in the pathophysiology of radiation-induced enteropathy. The aim of this thesis was to investigate the basic mechanisms behind leukocyte-platelet-endothelial cell interactions in the colonic microcirculation and intestinal leakage in response to radiotherapy. It was found that …
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Separation of gliadin peptides for investigation of the injurious agent(s) in gluten sensitive enteropathy
Crude gliadins isolated from three wheat varieties (Karl, Tam 107 and CS- 93) were subjected to in vitro hydrolysis by the extracellular enzymes pepsin, peptidase and pancreatin. Gliadins from one variety (Karl) also were exposed to the intracellular enzymes cathepsins Band D. A reverse phase high …
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Factors influencing the development of protective and pathological responses to Trichinella spiralis infection
… that the role of IL-4 in the development of enteropathy depends on host mouse strain. Conversely a role in Th2 cytokine signalling to cells of the macrophage/neutrophil lineage in limiting enteropathy was also demonstrated. This thesis also demonstrated that co-stimulation via ICOS and OX40 …
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Optimization of Clinical Approach and Dietotherapy in Gluten Enteropathy /// Оптимизиране на клиничния подход и диетолечението при глутенова ентеропатия
Глутеновата ентеропатия е едно от най-разпространените автоимунни стомашно чревни разстройства. Заболяването е хронична, автоимунна форма на ентеропатия – с прицелен орган тънкото черво, в генетично предразположени деца и възрастни, малко по-често при жени отколкото при мъже и води до поява на …
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Mast cells in gastrointestinal helminth infection
… responses to T. spiralis, and the development of enteropathy was not required for the rejection of the parasite. Therefore, different mechanisms may be responsible for the expulsion and for the development of enteropathy. In addition, Wsh mice may be more appropriate models than W/Wv mice in such …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
… and stroke. It has long been accepted that NSAID enteropathy is an unavoidable consequence of simultaneously inhibiting both cyclooxygenases (COX) -1 and -2 to suppress prostaglandin synthesis. Operating under this assumption, I had developed a novel mouse model of inducible COX-1 + COX-2 deletion …
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Screening Detected Celiac Disease in Children
… (tTG-IgA) and the degree of gluten induced enteropathy and applying the revised 2012 ESPGHAN guidelines on screened CD cases. Additionally, to evaluate the adherence to the GFD in adolescents with screening detected CD. Method: We performed a two-phased screening study, ETICS (Exploring the …
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The kinetics of albumin metabolism in experimental protein calorie malnutrition
… loss, (e.g. burns, nephrosis·, protein loosing enteropathy) or to defects in protein· absorption (gastro-enteritis, steatorrhoea) or synthesis (liver disease). Where the caloric intake is relatively normal the disease produced, kwashiorkor, is characterised by retardation of growth and …
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… from an infant with low fecal concentrations of enteropathy biomarkers and responded well to their first dose of oral rotavirus vaccine (healthy human gut microbiota "HHGM"); or pigs were colonized with HGM from an infant with high fecal concentrations of enteropathy biomarkers and a poor …
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HUMAN GENETIC VARIANTS IN ESSENTIAL SPLICING FACTORS AND THEIR IMPACT ON IMMUNE PATHOLOGY
… cause immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome, and aberrant expression of FOXP3 has been associated with other diseases such as multiple sclerosis (MS) and non-small cell lung cancer (NSCLC). We previously described a single nucleotide polymorphism (SNP) in …
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Modeling congenital disorders of glycosylation in Caenorhabditis elegans: Genetic influences and structural consequences of N-linked glycosylation
… involvement to hypoglycemia and protein-losing enteropathy with normal development. Infants and children with CDG require nutrition supplements for maximal caloric intake and/or nasogastric tube or gastrostomy tube feedings. Orthopedic issues in adults require physical therapy, wheel chairs, …
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Nutritional status of adult patients with Crohn's disease receiving total parenteral nutrition in the home vs. in the hospital
… effects of sample size, and protein-losing enteropathy.
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ADAMTS13 Activity in Dogs with Chronic Enteropathies
… with CE, including those with protein losing enteropathy and thromboembolism.
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High throughput measurement and perturbation of tissues and tissue-derived cellular models
… of disease in Zambian adults with Environmental Enteropathy (EE). In doing so, we reveal key aspects of the biology of this neglected disease, including, the presence of surface mucosal cells in EE, an increase in WNT/ßcatenin signaling in the EE epithelium, and a more cytotoxic phenotype in EE T …
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Searching for Celiac Disease Screening-detected celiac disease in an HLA-genotyped birth cohort
… Celiac disease is a common immune mediated enteropathy strongly associated with HLA-DQB1*02 (DQ2), *0302 (DQ8), or both and the presence of tissue transglutaminase autoantibodies (tTGA). Prevalence studies have revealed that most affected individuals go undetected because of subclinical …
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Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis
Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and …
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Changes in Pancreatic and Jejunal Histopatholgy and Serum IFN-γ, TNF-α Levels in Type 1 Diabetes: Role of Chloroform Methanol Soluble Gliadin Proteins
… there were no significant differences in jejunal enteropathy parameters (i.e. lymphocytic infiltration, mucosal thickness, epithelial erosion, jejunal villi flattenings), jejunal CD4+ and jejunal γδ TCR+ cell counts; pancreatic insulitis scores, lymphoid tissue content after removing the CM …
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THE ROLE OF MOLECULAR SIGNATURES IN COMPLICATED CELIAC DISEASE
… but essential, as RCD2 is associated with enteropathy-associated lymphoma (EATL) and a poor prognosis, with no effective treatment currently available. Flow cytometry (f-cyt) is the diagnostic modality of choice in RCD to characterize IELs phenotypes, however limited data are available on …
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Butyrophilin family genes as putative coeliac disease risk loci
… disease (CeD) is a T-cell mediated autoimmune enteropathy (1). CeD is triggered by the consumption of gluten, the collective name of a group of proteins present in wheat, rye, and barley (1, 2). The prevalence of CeD in the United Kingdom (UK) is around 1% and the number of new CeD diagnoses is …
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