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Showing 1 to 20 of 20 for “"enterohepatic circulation"”.
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Enterohepatic Circulation of Estrogens in the Domestic Pig, Sus Scrofa
Enterohepatic circulation (EHC) of estrogen involves secretion of estrogen in bile by the liver, release of bile from the gallbladder into the gastrointestinal tract, absorption of estrogen in bile from the gastrointestinal tract into venous blood going to the liver, and secretion of estrogen by …
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The effect of modification of mixed function oxidases and inhibition of enterohepatic circulation on concentration of estrogens in plasma in laying hens (Gallus domesticus)
The rate of metabolism and recirculation contributes to the rate of excretion and to concentration in the circulation. Steroids are substrates for mixed function oxidases (MFO). Enterohepatic circulation (EHC) of estrogens prolongs the half life of estrogens. Thus, the amount of recirculation and …
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The application of tracer techniques in endocrinology
… to be by way of the bile into the intestine . An enterohepatic circulation has been suggested, since some estrone was resorbed from the intestine into the blood and left the body in the urine.
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The Effects of Carbadox, a Synthetic Antimicrobial Agent, on Bile Acid Metabolism in The Domestic Pig
… bile acids of the young pig as they go through enterohepatic circulation without altering bile flow from the gall bladder, a surgical technique was developed to place indwelling catheters into the hepatic portal vein (HP) which allowed multiple sampling of the blood and did not affect the …
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Isotopic labeling of isoflavones from plant cell and organ culture for metabolic tracking in animal models
… and that kudzu isoflavone extracts underwent enterohepatic circulation. We then produced a 14C-radiolabeled kudzu isoflavone-enriched fraction from a high isoflavone yielding kudzu hairy root genotype in vitro, which was used to track the absorption, distribution, and elimination of kudzu …
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Binding of Steroid Hormones In Vitro by Water-Insoluble Dietary Fiber
… hormones by dietary fiber, leading to altered enterohepatic circulation of these hormones.</p>
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Adding Upstream Sequence and a Downstream Reporter to the Bile Acid Inducible Promoter of <I>CLOSTRIDIUM scindens</I> VPI 12708
… Most of the bile acids are reabsorbed into the enterohepatic circulation, but approximately five percent of these bile acids pass into the large intestine. These bile acids are swiftly deconjugated by the bacterial population, and then subjected to further intestinal bacterial chemical …
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Folate Metabolism in Normal and Tumour Bearing Mammals
… probably by intestinal metabolism during enterohepatic circulation, and the folate polyglutamates to p-acetamidobenzoyl-L-glutamate and the unidentified pteridine in situ in the ceils.
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An investigation of the effects of diet on the gastrointestinal microbiota, inflammation, and metabolic endotoxemia in adults
… GI barrier structure and function, and the enterohepatic circulation of bile acids. One of the mechanisms by which consumption of dietary fibers may contribute to decreased whole-body inflammation is through the prevention of metabolic endotoxemia, defined as a 2- to 3- fold increase in the …
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Porphyrin metabolism in congenital erythropoietic porphyria
… not excreted into bile and interruption of the enterohepatic circulation by binding porphyrins onto charcoal therefore does not benefit CEP. It may, however, be effective in the treatment of hepatic porphyrias in which the accumulated porphyrins are mainly excreted via the gut lumen.
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in liver and intestine. Consequently, FXR has become a very promising therapeutic target for the prevention and/or treatment of cholestasis, …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… their pharmacological action in the systemic circulation. However, our increasing understanding of their pharmacokinetics and chemical structures, suggests enhanced abundance of LOBs and lignans at the level of the intestinal epithelium due to the potential lack of permeation of LOBs, and …
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Chemical investigations into the physiology of bile acid skeletons
… role of bile acids. A recycling process called enterohepatic circulation increases the efficiency of bile acid usage during digestion and meanwhile, by reabsorption of bile acids modified by colon bacteria, increases the structural diversity of bile acids in vertebrates. While most of bile acid …
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The metabolic fate of benzo [a] pyrene in vivo
… were glucuronides and thio-ether conjugates. Enterohepatic circulation of B[a]P biliary metabolites was investigated in Sprague-Dawley rats.
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Charakterisierung des Gallensäuretransporters ASBT am Oozyten-Expressionssystem
… the re uptake of bile acids due to the course of enterohepatic circulation. The cRNA of the ASBT was injected in oocytes of Xenopus laevis and successful expression was verified by Wester-Blot analysis. As a well established substrate of the bile salt transporter taurocholic acid was chosen for …
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… in bile acid metabolism and disruption of enterohepatic circulation in the Abcc6-/- mouse model.<br /> Remodeling of the ECM in PXE fibroblasts in two- and three-dimensional culture proved to be particularly dependent on the expression of a gene cluster of matrix metalloproteinases (MMPs). …
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The Metabolic Impact of the Gut-Liver Bile Acid Signaling in Metabolic and Inflammatory Liver Disease
… and transported back to the liver via the portal circulation. Bile acids circulating in the enterohepatic circulation play important roles in maintaining bile acid, lipid and glucose homeostasis and inflammatory response. Disruption of bile acid homeostasis could contribute to various liver …
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Piperaquine - Bioanalys, drug metabolism and pharmacokinetics
… 1% of the total dose excreted by this route. Enterohepatic circulation would not contribute significantly to a prolongation of the terminal half-life. Piperaquine elimination half-life might be underestimated due to inadequate assay sensitivity and/or duration of sampling in published …
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PHARMACOKINETICS OF RESVERATROL, ITS MONOCONJUGATES AND ITS TRIMETHOXY ANALOG TMS
… and oral route. R3G was observed to undergo enterohepatic circulation. Explanation of R3G disposition in hepatocytes and enterocytes were proposed based on our own and reported results. In Chapter 6 we compared the differences in the kinetics of preformed versus in vivo formed metabolites …