Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"enteroendocrine cells"”.
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Sensory Transduction in Enteroendocrine Cells
… a central function of the gut epithelium where enteroendocrine cells act as sensor cells to secrete hormones in response to the luminal contents. This thesis focuses on voltage gated ion channels and the transient receptor potential (TRP) superfamily in I cells and enterochromaffin cells using …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
Enteroendocrine cells (EECs) of the gastrointestinal (GI) tract and islets of Langerhans (islets) of the pancreas are endocrine cells capable of sensing nutrient intake or the nutrient content of the blood and responding by secreting peptide hormones to control various physiological functions. This …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… body thanks to the presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such as nutrient digestion and absorption, …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… used to assess the development of the ENS and enteroendocrine cells (EECs), respectively. At PD1, the ENS of AGA animals was almost fully developed compared with PD14 and PD28. For SGA piglets, a delayed development of nerve endings was observed on PD1 associated with a less developed synaptic …
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Short Chain Fatty Acids Signaling through the G Protein-Coupled Receptor GPR41 in the Intestine.
… show that Gpr41 is expressed in the intestinal enteroendocrine cells. The localization of Gpr41 to enteroendocrine cells suggests that SCFAs signaling through Gpr41 induces the enteroendocrine cells to release a soluble mediator. In this study we sought to study the effects of SCFAs signaling on …
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G-Protein Coupled Receptors Modulating Incretin Hormone Secretion
… glucagon-like peptide-1 (GLP-1), secreted from K-cells and L-cells respectively, augment insulin secretion. In addition, GIP facilitates triglyceride storage and GLP-1 has anorexic effects. Incretins are released from the gastrointestinal tract in response to food ingestion. Great interest exists …
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A Novel Genetic Platform to Study Intestinal Tumorigenesis in Drosophila
Epithelial tissues rely on the activity of stem cells to sustain their structure and proper functioning. These stem cells are responsible for generating various types of cells, that are essential for the tissue's normal homeostasis, through division and differentiation. In order to ensure precise …
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Morfologia comparada do estômago e da junção gastroduodenal de morcegos da família Phyllostomidae (Mammalia, Chiroptera)
… the shallowest depth and the least number of cells. Three pattems of villi morphology (digitiform, foliaceous and pyramidal) are recognized at the gastroduodenal junction. The Brünner' s gland is present at the submucosa of the gastroduodenal j unction in almost all Phyllostomidae except …
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The metabolic sequelae of oesophago-gastric resection
… based peptidomics of human and murine enteroendocrine cells in the pre- and post-operative populations revealed no significant change in the underlying cellular pathways for nutrient sensing and gut hormone secretion, indicating that the altered hormone secretion is primarily driven by …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… the roles of secretory intestinal epithelial cells, specifically tuft cells and enteroendocrine cells (EECs), in colonic inflammation, revealing novel cellular and molecular dynamics. The initial study utilized IEC-specific Hnrnp I knockout mice to demonstrate significant upregulation of …
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Linking mosquito midgut and virus population biology at the molecular and cellular level
… of viral RNA suggesting enhanced replication in enteroendocrine cells and cells enriched for mitochondrial genes. In addition, we found no significant upregulation of mosquito immune genes associated with WNV infection at the whole-midgut level, rather, a significant positive correlation between …
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… investigate the contribution of innate lymphoid cells (ILCs) to immune protection of the intestinal barrier. Additionally, to understand complex epithelial host-pathogen interactions a novel in vitro model of small intestine organoids was developed. Data suggest that immunoprotection against …
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Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism
Goblet cells are key contributors to intestinal mucosal barrier function through their role in production of mucins and other important secretory products, which include trefoil factor 3 (TFF3) and resistin like molecule β (RETNLB). Goblet cell mucins show great structural heterogeneity but can be …
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NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE: NUCLEOBINDIN-1/2-ENCODED INSULINOTROPIC AND ENTEROTROPIC PEPTIDES
… (CCK) secreted by intestinal mucosal cells. Since both nesfatin-1 and intestinal hormones modulate insulin secretion, nesfatin-1 could regulate intestinal hormones to elicit its insulinotropic action. Nucleobindin-1 primarily regulates Ca2+ homeostasis. Like NUCB2, NUCB1 is also …
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Wnt Signals and Imaging Tissue Renewal in the Human Colonic Epithelium
… tissues in the mammalian body, with 10 billion cells being shed from its surface every day. Renewal of the intestinal epithelium takes place at the base of flask-like epithelial invaginations known as crypts. Within these crypts reside a stem cell population that continuously repopulates the …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
Enteroendocrine cells (EECs) are chemosensitive cells of the gastrointestinal epithelium that exert a wide range of physiological effects via production and secretion of hormones in response to ingested nutrients, bacterial metabolites and systemic signals. Glucagon-like peptide-1 (GLP-1) is one …
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Dynamic Responses at the Barrier Epithelium
… and the internal environment of the organism. Cells of the intestine simultaneously function as barrier, digestive organ, and sensory organ. Additionally, in many metazoan animals these functions occur in the context of active stem cell based turnover. Although substantial progress has been …
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Quantitation of enteroendocrine hormones as metabolic disease biomarkers in human biological matrices by liquid chromatography tandem mass spectrometry
… Many gut hormone peptides are secreted by enteroendocrine cells (EECs) and some, known as incretins, are released after a meal to control blood glucose and stimulate neuronal satiety. These are being studied as novel targets for treatment of metabolic diseases such as obesity. Traditionally …
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