Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"enteric neurons"”.
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… reperfusion affects the large intestine and the enteric nervous system (ENS). To do so an experimental ischemia/reperfusion (I/R) model was set up using rat large intestine. In order to study how the ENS reacts to various mediators of stress, primary cultures of myenteric neurons from rat small …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may occur in intestinal inflammation, due to the …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… and sometimes, early death. In HSCR, the enteric nervous system (ENS) does not develop completely, resulting in a region of bowel lacking neurons. HSCR can be treated by surgically removing aganglionic bowel, but many children with HSCR have poor motility even after surgery, especially …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… as well as a vast neuronal network, the enteric nervous system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of my thesis work. The studies as presented here are divided …
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Characterization of the Expression and Pathogenicity of Alpha-Synuclein in the Enteric Nervous System
… not only in brain tissues, but also in the enteric nervous system (ENS). Here, we aimed to reevaluate the localization pattern of α-Syn in the ENS of PD patients and control subjects. Formalin-fixed and paraffin-embedded (FFPE) full-thickness colon resections were used to characterize α-Syn …
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The effect of ageing on the innervation and total collagen content of human colon
This thesis addressed the enteric innervations and total collagen content and its distribution within the functional sublayers, namely: mucosa, submucosa and muscularis externa (circular muscle (CM) and taenia coli (TC)) in ageing human colon. Macroscopically normal ascending (AC) and descending …
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Gastrointestinal (GI) Motility is Unaltered by Feeding in Zebrafish
… of motility patterns appears to be controlled by enteric neurons and interstitial cells of Cajal (Huizinga et al., 1995, Farrugia et. al., 2003, Sanders et.al., 2006, Rich et. al., 2007). Although several research laboratories investigate GI motility in zebrafish larvae, no standard protocol for …
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Neuronal plasticity in the enteric nervous system motor pathways
… underlying neurotransmission within the enteric nervous system are not yet known. Acetylcholine acting on nicotinic receptors mediates the majority of fast synaptic transmission between enteric neurons, however, recent studies suggest that the peristaltic motor pattern can occur during …
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NOVEL APPROACHES TO TESTING GASTRO INTESTINAL FUNCTION IN VITRO: CONTROLLING SIGNAL ACQUISITION, TISSUE COMPOSITION, OR THE PLATFORM
… apparatus which includes smooth muscle, enteric neurons, and interstitial cells of Cajal (ICC). Depletions of these cell populations are associated with several motility disorders, and their significant effects on function are uncertain. In this thesis, several different approaches are …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
… the aim of describing expression of GnRH in the enteric nervous system (ENS) and antibodies against GnRH in serum. In a control group GnRH was present in about 50% of human myenteric neurons. A subgroup of patients with severe dysmotility expressed antibodies against GnRH and had reduced …
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A Molecular Basis for Macrophage Control of Enteric Nervous System Function
… between intestinal macrophages and the enteric nervous system regulate gastrointestinal motility, yet we have an incomplete understanding of the molecular mediators of this crosstalk. Here we identify complement component 1q (C1q) as a macrophage product that regulates gut motility. …
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Neuroglial differentiation and neo-innervation in extracellular matrix-based tissue engineered innervated smooth muscle sheets
Excitatory and inhibitory motor neurons of the myenteric plexus in the enteric nervous system regulate and coordinate smooth muscle motility. Enteric neurons and glia of the myenteric plexus are organized into ganglia, that are surrounded by an extracellular matrix composed primarily of collagen …
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The Role of Kitlb on Development of Coordinated Muscular Contractions in the Zebrafish Gastrointestinal Tract
… interstitial cells of the Cajal (ICC) and enteric neurons. ICC act as pacemaker cells in the GI tract and set the frequency of spontaneous contractions. Altering ICC density results in uncoordinated GI muscular contractions. Our lab examines the role of ICC in GI motility and is focused on …
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… such as Hirschsprung disease (HSCR). In HSCR, neurons are absent from variable lengths of the gastrointestinal tract due to a failure of neural crest cell (NCC) colonization or development, leading to megacolon and/or the failure to pass meconium. Enteric neurons are derived from neural crest …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… major intestinal functions are coordinated by neurons within the enteric nervous system (ENS). While intestinal inflammation initially causes a profound loss of enteric neurons, the ENS demonstrates remarkable changes in neuronal structure and function to retain control of gastrointestinal …
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… interactions between ILC2s and distinct enteric neuronal populations not yet explored. In this thesis, a population of murine enteric neurons was identified as a meaningful player in the regulation of type 2 lymphocyte responses in steady-state conditions and after infection with …
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A Fundamental Investigation into the Presence of Interstitial Cells of Cajal within the Gastrointestinal Tract of Dania rerio
… between interstitial cells of Cajal (ICC), enteric neurons, and smooth muscle cells. Kit positive immunoreactivity has been extensively utilized as a marker for ICC; these cells function to generate rhythmic depolarization in the GI smooth muscle termed the electrical slow wave. Coordinated …
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L'infiammazione intestinale nell'animale sperimentale come modello per lo sviluppo di nuovi farmaci: ruolo della via tachichininergica nelle malattie infiammatorie intestinali
… the extrinsic primary afferent nerve fibres and enteric neurons of the gut: they exert their action through three distinct receptors, termed NK1, NK2 and NK3. SP modulates intestinal motility and enteric secretion, acting preferentially through the NK1 receptor. SP neural network and NK1 receptor …
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Human intestinal cells across space and time
… as well as key cell types (e.g. epithelium, enteric neurons, stromal and immune cells) required for the proper intestinal function, will be summarized. As an intestinal surface area, innervation and immunity are established during in utero development, this chapter will also outline the …
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