Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"enteric nervous system (ENS)"”.
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Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System
The vertebrate enteric nervous system (ENS) consists of a series of interconnected ganglia within the gastrointestinal (GI) tract, formed during development following the migration of enteric neural crest cells (ENCCs) into the primitive gut tube. Much work has been done to unravel the complex …
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… megacolon and/or the failure to pass meconium. Enteric neurons are derived from neural crest cells (NCC); hence HSCR is associated with incomplete NCC development or colonization of the GI tract. We investigated our hypothesis that RDH10 is necessary for proper NCC contribution to the enteric …
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Characterization of the Expression and Pathogenicity of Alpha-Synuclein in the Enteric Nervous System
… not only in brain tissues, but also in the enteric nervous system (ENS). Here, we aimed to reevaluate the localization pattern of α-Syn in the ENS of PD patients and control subjects. Formalin-fixed and paraffin-embedded (FFPE) full-thickness colon resections were used to characterize α-Syn …
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Sistema nervoso enterico e scrapie sperimentale in ovini di razza sarda con diversa suscettibilità genetica nei confronti della malattia
Sebbene il sistema nervoso enterico (“enteric nervous system”, ENS) svolga un ruolo cruciale nella patogenesi della Scrapie ovina, non esistono tuttavia in letteratura dati sulle popolazioni cellulari progressivamente coinvolte nel corso dell’infezione, né sugli eventuali danni morfo-funzionali da …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may occur in intestinal inflammation, due to the …
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Development of Novel Methods to Study Host-Microbe Interactions In The Larval Zebrafish Gastrointestinal Tract
… assay was then used in combination with enteric nervous system (ENS)-deficient zebrafish, a model for Hirschsprung’s disease (HSCR), to study the effects of the ENS on the colonization and virulence gene expression of enterohemorrhagic <em>Escherichia coli</em> (EHEC). My findings suggest …
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Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… reperfusion affects the large intestine and the enteric nervous system (ENS). To do so an experimental ischemia/reperfusion (I/R) model was set up using rat large intestine. In order to study how the ENS reacts to various mediators of stress, primary cultures of myenteric neurons from rat small …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… functions are coordinated by neurons within the enteric nervous system (ENS). While intestinal inflammation initially causes a profound loss of enteric neurons, the ENS demonstrates remarkable changes in neuronal structure and function to retain control of gastrointestinal functions. Expression …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… and sometimes, early death. In HSCR, the enteric nervous system (ENS) does not develop completely, resulting in a region of bowel lacking neurons. HSCR can be treated by surgically removing aganglionic bowel, but many children with HSCR have poor motility even after surgery, especially …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
Abstract: In this thesis the questions “do enteric neurons adapt to survive in conditions of obesity/type 2-diabetes (T2D) related metabolic imbalances? Or do they die?” are asked. Obese and T2D patients have high rates of gastrointestinal (GI) symptoms. The GI tract comprises the body’s largest …
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Influence of food intervention on enteric nervous system and enteroendocrine cells development in a small for gestational age piglet model
… birth weight and diet on the development of the enteric nervous system (ENS) and entero-endocrine system (EES) during the first month of life, via multivariate analyses. Newborn SGA or AGA (average for gestational age) piglets were randomized into two diet groups: sow reared (SR, 24h/day with the …
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
… the aim of describing expression of GnRH in the enteric nervous system (ENS) and antibodies against GnRH in serum. In a control group GnRH was present in about 50% of human myenteric neurons. A subgroup of patients with severe dysmotility expressed antibodies against GnRH and had reduced …
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From Gut to Brain - αSynuclein pathology spreading in a new transgenic mouse model
… initiation of αSyn pathology in the peripheral nervous system, more precisely in the enteric nervous system (ENS) and/or olfactory system. Several studies have been performed in patients as well as in animal models to investigate the spreading of αSyn from the periphery to the central nervous …
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Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… MSNs. Using this model, we conducted a multidimensional analysis to identify features that contribute to MSNs vulnerability. Transcriptomic analysis of small pools of MSNs collected from 8-week-old, presymptomatic mice revealed an overall downregulation of retrotransposable elements in both …
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Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System
<p>The gastro-intestinal tract is the most extensive mucosal surface in mammals and harbors the most numerous immune cell reservoir as well as a complex and autonomous nervous system. The GI tract is continuously exposed to foreign antigen and potentially toxic chemicals through the ingestion of …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
The enteric nervous system (ENS) is of critical importance to an organism, as it controls the function of the gastrointestinal system. The ENS is remarkably complex, and although sculpted early in development, has to maintain plasticity throughout adulthood in the face of changing food levels, …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… tissue functions, including digestion, sensing and absorption of nutrients, and excretion of waste products. In performing these roles, the intestine faces the unique challenge of remaining tolerant to harmless or beneficial diet- and microbederived stimuli, while simultaneously …