Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"enteric infections"”.
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A cultivable primate calicivirus causes enteric infections in gnotobiotic piglets
Many enteric caliciviruses cause acute gastroenteritis in humans and animals. Examples of these include human norovirus (NoV), human sapovirus, and the newly discovered recoviruses. It is estimated that human NoV accounts for over 95% of nonbacterial acute gastroenteritis worldwide. However, …
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The Effects of Water Storage and Meteorological Conditions on Enteric Infections from a Matched-Control Trial in Beira, Mozambique
… has the potential to reduce the burden of enteric diseases, including diarrhea, in rapidly growing urban centers. However, water intermittency and water storage practices, as well as impacts of meteorological conditions, may interfere with the progress made by drinking water interventions. …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… as well as a vast neuronal network, the enteric nervous system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of my thesis work. The studies as presented here are divided …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
… of pathological conditions, including unresolved infections, and inflammatory diseases. In this study, we aim to elucidate novel mechanisms involved in host-pathogen interactions during Helicobacter pylori and Clostridium difficile infections. Indeed, this work integrates preclinical in vivo and …
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The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… SHIP plays a role in controlling bacterial infections in vivo remained unknown. Salmonella enterica causes human salmonellosis, a disease that ranges in severity from mild gastroenteritis to severe systemic illness, resulting in significant morbidity and mortality worldwide. The focus of …
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The determination of veterinary antibiotics in live animals and animal products
… are widely used in the treatment of bacterial infections e.g. aminoglycosides for enteritis and mastisis and macrolides for enteric infections. They have also been used as feed additives for growth promoting. As a result, legislation has been laid down by the European commission in which member …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… to a new host. Most of the biomass of the enteric biofilm is a thick extracellular matrix composed of curli, cellulose, BapA, and extracellular DNA. Curli are functional amyloids with a rich β-sheet structure strikingly similar to pathological and immunomodulatory human amyloids such as …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
… damage in the form of lupus nephritis. Viral infections have long been associated with the development of systemic autoimmune disease, but the mechanisms by which chronic bacterial infections may promote autoimmunity remain unclear. In chapter three we show that a component of bacterial …
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Elucidating fecal contamination exposure in low-income countries, the contribution from child feces disposal practices and soil ingestion, and links to child health
Enteric pathogens transmitted via fecal-oral pathways cause enteric infections that have substantial health and human capital consequences, making it critical to reduce child exposure to fecal contamination. Current water, sanitation, and hygiene programs in low-income countries often focus on …
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Caspase isoforms in inflammasome activation
… roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the pro-inflammatory cytokines pro-IL-1β and pro- IL-18 to their active form and cleavage of gasdermin D to induce pyroptosis. Caspase-1 is the main inflammatory caspase responsible …
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Contributions of type 17 immunity and type I interferon signaling to Salmonella-induced autoimmunity
… many classical autoimmune diseases and bacterial infections. Previous research from our lab has shown that Salmonella biofilm-associated amyloid protein, curli, is a potent inducer of systemic inflammation and autoimmune responses. Curli induces immune responses via various receptors, on the cell …
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The effects of a yeast probiotic, saccharomyces cerevisiae boulardii, on common sow stressors and their effect on maternal-fetal programming
… morbidity and mortality in pigs, increases in enteric infections leading to increases in clinical diarrhea, and reduced weight gains (Hao et al., 2014). The utilization of probiotics as a method of promoting healthy gut bacteria may potentially restore the composition of the gut microbiome and …