Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 297 for “"enhancers"”.
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Enhancers and super-enhancers in human disease and therapy
… core promoter and at distal regulatory regions, enhancers, which are looped into close physical proximity with the core promoter. Enhancer regions are typically utilized in a cell-type-specific manner and help to drive the distinct gene expression programs that define diverse cell identities. New …
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β-Globin Enhancers Regulate Bistable Gene Expression States
Multiple enhancers can coordinately regulate a target gene to ensure robust expression. Under the failure rate model, each redundant enhancer contributes a probability of target gene expression in the cell, and genetic deletion will cause single-cell expression phenotypes. However, this model has …
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Screen for Suppressors and Enhancers of Excitotoxic Neurodegeneration
<p>Excitotoxicity is an important and frequently observed neurodegenerative process. Excitotoxicity mediates brain damage in a range of diseases and conditions including stroke, and is triggered by excessive stimulation of glutamatergic synapses. In spite of extensive studies, the molecular …
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Characterizing and predicting enhancers in the human genome
… various functional sequences like promoters and enhancers (4). However, the availability of this data is very limited, as these assays have been performed on a limited number of cell types, and the distribution of chromatin states varies across different cell types. We therefore took a …
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ADP-Heptose and Nucleotide Enhancers Drive Fusobacteria-Induced Inflammation
<p>Colonization by <em>Fusobacteria</em> is associated with diverse inflammatory diseases and cancers, but the underlying molecular mechanisms that drive these associations remain elusive. Here I report studies showing that among commensal bacteria, <em>Fusobacteria</em> are uniquely potent …
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Characterising the function and evolution of enhancers in Drosophila
Enhancers are important modular cis-regulatory elements that precisely control the spatial and temporal expression of most genes. Therefore understanding how enhancers work and evolve is crucial for understanding the regulation of most developmental processes in animals. In my PhD project, I …
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Congenital Heart Defect-Associated Enhancers Shape Human Cardiomyocyte Lineage Commitment
Pages vii-xiv are misnumbered as pages vi-xiii.
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… gene expression, most of which are distal enhancers. These suggest that enhancers play essential roles in HSC gene deregulation and liver fibrosis. However, it remains underexplored in terms of the category of active enhancers in human HSCs and their contribution to liver fibrosis. Here we …
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QSAR modeling of chemical penetration enhancers using novel replacement algorithms
… to cross the skin barrier. Chemical Penetration Enhancers (CPEs) are used to promote the absorption of solutes across the dermal layers. In this investigation, a Quantitative Structure-Activity Relationship (QSAR) model is applied to relate chemical penetration enhancer structures with the flux …
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Use of physical enhancers for gastrointestinal and transdermal drug delivery
… using 20 kHz US alone. The power of physical enhancers, such as US, is underscored by their ability to permeabilize a tissue layer, such as the skin, which is designed to serve as a barrier. The use of physical enhancers in a tissue that lacks this barrier, such as the GI tract, presents an …
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Enhancers and phase separation in the control of gene expression
… of genes is regulated by DNA elements called enhancers, which are bound by transcription factors and coactivators, leading to the recruitment of RNA polymerase II and the production of RNA. Enhancers are thought to loop to specific gene promoters to stimulate transcription, but the mechanisms …
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Investigating the function of DNA G-quadruplex structures in human enhancers
… in diverse genomes, including promoters and enhancers. Enhancers interact with target promoters through 3D folding of interphase chromosomes to regulate gene transcription. However, the functional relevance of G4 structures at non- coding enhancer elements remains poorly understood. In this …
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The career maturity of graduate students identified as enhancers or changers
… significant difference between Career Enhancers and Career Changers in the Exploration Stage of the ACCI. Age in relation to career maturity was found to be statistically significant. No statistically significant relationships were found between gender, major field of study, or years …
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SOMATIC MUTATIONS AT FRAGILE ENHANCERS OF LINEAGE- IDENTITY EPITHELIAL GENES IN BREAST CANCER.
… identified a unique class of CtIP-bound active enhancers, which share the consensus motif of the GRHL1/2 transcription factors and are involved in the establishment and maintenance of the epithelial phenotype. We found that GRHL1/2 bind to these enhancers and recruit CtIP, linking recruitment of …
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Genome-wide prediction of developmental enhancers and analysis of evolutionary plasticity in Drosophila
… method utilizes paired motifs to identify enhancers from non-functional elements. Application of this paired motifs approach achieves a genome-wide prediction with high specificity (94 percent) and sensitivity (60 percent). Paired motif prediction performs better than single motif …
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Targeted Deletion of Functionally Validated Enhancers Defines Their Role In Mouse Limb Development
<p>Transcriptional enhancers are genomic DNA sequences that contain clustered transcription factor (TF) binding sites. When combinations of TFs bind to enhancer sequences they act together with basal transcriptional machinery to regulate the timing, location and quantity of gene transcription. …
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Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers
… the signal directly to the nucleus. How enhancers decipher NICD in the real time of developmental decisions is not known. In order to determine how enhancers respond to Notch activity in real time, I have used the MS2-MCP system to visualize nascent transcripts in Drosophila embryos. To …
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… underlying mechanism involves the activation of enhancers – knockdown of JMJD2d attenuates stimulus-induced enhancer activation, which is normally characterized by the accumulation of acetylated H3K9 and increased enhancer RNA transcription. In short, JMJD2d appears to control IFN responses by …
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Transdermal and transbuccal delivery of lidocaine and nicotine : combined effects of iontophoresis and chemical enhancers
… on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential delivery routes have the advantage of avoiding …
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