Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"enhancer transcription"”.
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INVESTIGATING THE BASES OF THE SPECIFICITY OF THE RESTRICTOR COMPLEX FOR THE TERMINATION OF NONCODING TRANSCRIPTION
Rampant transcription initiation occurring at the tens of thousands of cis-regulatory regions in the genome can be detrimental to the normal functioning of the cell. Several transcription termination mechanisms act to keep the initiation of non-productive transcription in check. The Restrictor …
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Extraction and identification of frequent sequential patterns in transcription factor binding site organization of enhancers
… such as ENCODE to identify cell-type specific enhancers, and transcription factor binding sites, it is possible to better understand enhancer regions of the genome responsible for promoting transcriptional activity. Using frequent sequential pattern mining techniques from the classical data …
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Cis-regulatory module analysis: inferring regulatory networks and underlying mechanisms
… of the genes. Cis- regulatory modules (CRMs/enhancers), main players of this regulatory process, are typically short (<1kb) sequences that are embedded in non-coding regions of the genome. They harbor cis-elements (binding sites/motifs) for one or more related transcription factors (TFs) and …
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Computational modeling of gene expression from regulatory sequences
… occurs mostly at the primary stage known as “transcription”. Teasing out the details of transcriptional regulation is therefore a core focus of biological research. Transcriptional regulation of gene expression is dictated by regulatory DNA sequences, often called cis-regulatory modules (CRM; …