Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"enhancer activation"”.
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Molecular mediators of cardiac-specific enhancer activation
… (TEAD) TF TEAD1 as a candidate regulator of enhancer activation during cardiac-lineage commitment. We then used an inducible degron-tag strategy to conditionally deplete TEAD1 and observed an abnormal beating phenotype in CMs. Further mechanistic studies revealed that TEAD1 was necessary for …
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… involving DNA. In particular, transcriptional activation depends on the interplay of dozens of chromatin modifiers to establish an epigenetic landscape permissive of gene transcription. Among the most dynamic histone modifications are the acetylation and methylation at histone 3 lysine 9, but …
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Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers
… across tissues and developmental contexts. After activation of the pathway via interaction of the Notch receptor with its ligands on adjacent cells, the intracellular domain (NICD) transduces the signal directly to the nucleus. How enhancers decipher NICD in the real time of developmental …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
… increased heterochromatin to subtle changes in enhancer activation. An increased understanding of the role of chromatin in neural stem cell dynamics could become the basis for potential therapies for neurodegenerative or neurodevelopmental disorders. Drosophila melanogaster neural stem cells …