Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 521 for “"enhancer"”.
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ROLE OF A SPECIFIC NANOG SUPER-ENHANCER ERNA IN EPIGENETIC REMODELING AND ENHANCER-PROMOTER INTERACTION
During last years, the role of enhancer RNAs has been in part explored; however, it’s still not clear the exact role these transcripts carry out concerning gene regulation. In this work, the role of eRNAs transcribed from the region 5kb upper the TSS of Nanog gene in mESCs has been investigated. In …
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Molecular mediators of cardiac-specific enhancer activation
… (TEAD) TF TEAD1 as a candidate regulator of enhancer activation during cardiac-lineage commitment. We then used an inducible degron-tag strategy to conditionally deplete TEAD1 and observed an abnormal beating phenotype in CMs. Further mechanistic studies revealed that TEAD1 was necessary for …
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Interdomain Repression in the Enhancer Binding Protein NorR
… regulated by NorR, a member of the bacterial Enhancer Binding Protein (bEBP)-family that activates σ54-dependent transcription of the norVW genes under conditions of nitrosative stress. Binding of NorR to three conserved enhancer sites upstream of the norVW promoter is essential for …
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… for neural stem cells and regulated by the enhancer located on the second intron of the gene. The second intron is highly conserved among species and crucial for the nestin expression in central nerve system (CNS) progenitor cells. The transgenic mice that constructed to express green …
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Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses
… and was thus named the genomic RNA packaging enhancer element (GRPE). To determine if the GRPE was conserved across lentiviruses, using the same approach as Chamanian et al., deletions in similar regions of the SIVmac239 and FIV 34TF10 genomes were done to measure their impact on RNA …
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Characterization of novel DNA binding activities at the immunoglobulin 3' enhancer
… chain is influenced, in part, by an intronic enhancer region located 3' to the V,D, and J gene segment regions. The regulatory elements within this enhancer show high levels of sequence homology between mouse, rat, rabbit, and human, indicating their evolutionary significance. SRY, SpiB, LM02, …
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Characterizing the Mechanisms Regulating Enhancer Commissioning by MyoD in Muscle Cells
… by large groups of neighbouring transcriptional enhancer regions known as super-enhancers. Enhancer regions are opened and commissioned by master transcription factors such as MyoD. While MyoD is crucial for muscle development and differentiation due to its role in initiating muscle-specific gene …
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Effects of the OTX2ECR2 enhancer & PROX1 overexpression in murine retina development
… populations, it requires the activity of an enhancer called <em>OTX2ECR2</em>. Past studies demonstrated that retinal progenitor cells that had activity of <em>OTX2ECR2</em> turned into horizontal cells, which require OTX2 for cell genesis and survival, and photoreceptors which require OTX2 …
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Investigating the chromatin dynamics that underlie CRISPRi-validated enhancer-promoter interactions
Discovered in the 1980s, enhancers have grown to become important cis-regulatory elements responsible for both temporal and tissue-specific gene regulation coordinating cell differentiation processes, pathological responses and disease progression, and cellular functions in normal physiological …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
… transcriptional control elements, such as gene enhancers, are required for this, with many such elements localising considerable distances away from their target promoters. Enhancers commonly convey their regulatory signals to target promoters by forming physical contacts with them through …
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Predicting enhancer regions and transcription factor binding sites in D. melanogaster
… combinations of features for predicting enhancers and transcription factor binding sites.
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… These findings suggest that Tcf7l1-mediated enhancer decommissioning serves as a critical mechanism by which pluripotent cells rapidly alter the response to signaling pathways in preparation for gastrulation, and it may be a mechanism used in diverse cell types for modulating effects of …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… on a newly discovered myeloid-specific cis-enhancer which is controlled by the haematopoietic transcription factors PU.1 and RUNX1. Interference with their binding leads to abrogation of Irf8 expression, subsequently to disturbed cell fate decisions, demonstrating the importance of these …
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Manipulating Enhancer Rna Activity to Study Their Roles In Gene Regulation and Cancer
<p>Enhancers are essential regulatory elements that precisely control gene transcription during development and disease. Especially in cancer, enhancers modulate tumor gene expression, and in some cases directly drive tumorigenesis. With the recent advances in next-generation sequencing, …
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