Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"enhanced permeability and retention (EPR) effect"”.
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Novel non-viral delivery systems for cancer gene therapy
… particle size, Zeta potential, DNA condensation) and evaluating their in vitro transfection. Conjugation of targeting ligands such as transferrin and lactoferrin is an attractive tool to improve specificity and cellular uptake of carriers, and surface modification of dendrimers with hydrophilic …
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Engineered Nanomaterials for Targeted Imaging and Therapy
… can help direct the best treatment strategy and improve patients' survival. The unique and tunable properties of nanoparticles facilitate the development of diagnostic imaging tools for earlier diagnosis and disease staging, and they can provide fundamental information on the pathological …
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Novel Lanthanide Containing Polymers for Nucleic Acid Delivery and Monitoring of Polyplex Dynamics
… real promise to offer less severe (lower side effects) as a treatment for life threatening and difficult to treat diseases such as cancer, heart disease or Alzheimer's disease. Theranostic nanomaterials that combine diagnostic imaging and therapeutic delivery, have potential to minimize the …
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Design of functional polymeric materials for cancer-targeted drug delivery and cellular capture and isolation
… unique properties, multiple functionalities, and elaborate architectures for a variety of applications. In the drug delivery field, the use of synthetic polymers as nano-sized drug carriers in cancer nanomedicine has gained tremendous interest as an alternative to conventional small molecule …
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Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles
… potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… worse prognosis due to aggressive phenotypes and resistance to radiotherapy and chemotherapy. The overall goal of this work is to improve response to conventional cancer therapies by targeting tumor hypoxia. This has been carried out and evaluated through the use of polymersome-encapsulated …