Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"engineered tissues"”.
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Modulation of mesenchymal stem cell invasion into decellularized engineered tissues
… matrix (ECM) in developing and mature tissues, where the organization gives the tissue its unique functional properties. This dissertation will discuss research that is fundamental to the understanding of the interaction of cells with the extracellular matrix (ECM), a concept that is …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
Transplantable engineered organs could one day offer life-saving treatments for patients with end-stage organ failure. However, producing hierarchical vascular networks that sustain the viability and function of cells within human-scale organs after implantation remains a major challenge. …
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Adaptive fabrication of biofunctional decellularized extracellular matrix niche towards complex engineered tissues
Recreating organ-specific microenvironments of the extracellular matrix (ECM) in vitro has been an ongoing challenge in biofabrication. In this study, I present a biofunctional ECM-mimicking protein scaffold with tunable biochemical, mechanical and topographical properties. This scaffold, formed by …
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Combined ultrasound, photoacoustic and elasticity microscope for tissue engineers
… to have quantitative functional assays of engineered tissues is limited to existing invasive methods like biopsy. Hence, an imaging tool for non-invasive and simultaneous evaluation of the anatomical and functional properties of the engineered tissue is needed. In this thesis, we present an …
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POLY(N-ISOPROPYL ACRYLAMIDE)-COATED SURFACES: INVESTIGATION OF CYTOTOXICITY WITH MAMMALIAN CELLS AND THE MECHANISM OF CELL DETACHMENT
… there is a rising need worldwide for replacement tissues and organs. One way to address this growing need is through engineered tissues, such as those generated from stimulus-responsive polymers. Stimulus-responsive polymers undergo a physical or chemical change when a stimulus is applied. One …
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Optimization of primary endothelial culture methods and assessment of cell signaling pathways in the context of inflammation
… for clinical treatment of diseases where host tissues or organs need to be replaced. Progression of engineering metabolically complex organs and tissues has been severely limited by the lack of established, functional vasculature. The thesis work described herein focused on methods of …
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Engineering Dynamic Granular Composites for the Repair of Cartilage Tissue
… are being used as ‘building blocks’ to generate engineered tissues. MSC spheroids can fuse together to produce high cell density, macroscopic tissues with enhanced functional properties; however, their potential is hindered by challenges in the stabilization of and control over fusion. Hydrogel …
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Hydrogel cell encapsulation for tissue engineering
The engineering of artificial tissues for restoration or replacement of organ function holds the potential to alter the landscape of medical therapeutics. In many tissue engineering approaches, cells seeded within 3D porous structures are expected to remodel into tissue-like structures. Despite …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… evaluated for spatially defined drug delivery to engineered tissues. Lastly, exogenously controlled drug release was demonstrated using a novel gold-coated hydrogel and focused ultrasound. Together, these studies have presented new biomaterial systems as versatile tools for controlled drug …
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The interplay of matrix rigidity and mechanical stretching for the development of artificial skin
… and replace non-functional organs. Many engineered tissues have been attempted in the past decade including skin, blood vessel, cartilage and bone but they lack the mechanical properties and biological functionality of their real counterparts which leads to failure in vivo. Matrix …
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Engineering human hepatic organoids for in vitro liver modeling and implantable cell therapies
… inclusion of exogenous non-parenchymal cells in engineered tissues to support engraftment, an important translational milestone. Finally, we established a strategy for rapid vascularization and scale-up of engineered liver tissues to move this therapeutic idea closer to clinical reality. These …
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Multifunctional bioactive polymers for the fabrication of tissue engineering scaffolds and the treatment of tissue ischemia
… Also, the need to increase the size of engineered tissues and treat ischemic diseases requires new methods to improve blood vessel growth. Therefore, the overall goal of this thesis is to develop advanced strategies for the design of hydrogel scaffolds which can tune the physical …
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Structure-functionality relationship of collagen scaffolds for tissue engineering
… to create artificial organs or replace damaged tissues using animal cells and other components. For successful tissue regeneration, many factors should be taken into account, however, three components are most crucial: cell, scaffold, and soluble factor(s). In order to check the functionality …
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Assessment of the biocompatibility, stability, and suitability of novel thermoresponsive films for the rapid generation of cellular constructs
… rapid formation of cellular constructs, such as engineered tissues and spheroids for cancer cell research.
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Modelling Cell Orientation In Artificial Tissues
Engineered tissues have many potential applications both as experimental systems and in therapeutic devices and treatments. Specially, there is potential to repair damaged spinal cord, however work is still needed to predict the process of tissue growth. Computational physics has potential to …
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Analysis and modeling of inelasticity in tendon: viscoelasticity, damage, and plastic deformation
Tendons are soft connective tissues that connect the muscular system to the skeleton. Tendons are abundant in human body and their primary function is to enable transmission of mechanical force. These tissues are prone to overuse and disease. To understand the relationships between tendon's …
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Uncovering Biological Mechanisms of Immunomodulatory Biomaterials for Encapsulated Cell Therapies
… in a variety of therapeutics including vaccines, engineered tissues, and cell therapies. Biomaterials enable a range of functionalities such as localized delivery, sustained release, and responsiveness. In the context of cell therapies, biomaterials can protect encapsulated cells from immune …
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Promotion and control of angiogenic activity in poly(ethylene glycol) diacrylate hydrogels for tissue engineering applications
… can be used to develop vascularized, functional engineered tissues. The field of tissue engineering has the capability of providing greatly needed biological organs and tissues for transplantation therapy. In living tissues of physiologically relevant size, metabolically active cells far from a …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… and will inform the development of engineered tissues, medical devices, and biological materials for tissue repair and regeneration.
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Shape Memory Polymers as 2D Substrates and 3D Scaffolds for the Study of Cell Mechanobiology and Tissue Engineering
… signals, and scaffolds to regenerate damaged tissues. To develop new, functional, engineered tissues, it is becoming increasingly important to understand how cell-material interactions affect the cell mechanobiological response. As a result, recent efforts have focused on developing complex …
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